ZR Li, HY Guo , ZP Zhang, . STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅸ. STUDY ON PRODRUGS OF SOME PYRIDONECARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1991, 26(2): 111-116.
Citation:
ZR Li, HY Guo , ZP Zhang, . STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅸ. STUDY ON PRODRUGS OF SOME PYRIDONECARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1991, 26(2): 111-116.
ZR Li, HY Guo , ZP Zhang, . STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅸ. STUDY ON PRODRUGS OF SOME PYRIDONECARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1991, 26(2): 111-116.
Citation:
ZR Li, HY Guo , ZP Zhang, . STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅸ. STUDY ON PRODRUGS OF SOME PYRIDONECARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1991, 26(2): 111-116.
STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS Ⅸ. STUDY ON PRODRUGS OF SOME PYRIDONECARBOXYLIC ACIDS
Synthesis and antibacterial activity of pivaloyloxymethyl esters of norfloxacin, ciprofloxacin and their N-substituted derivatives are reported. In vivo antibacterial activities (EDso) of ⅢAa, b, e; ⅢBa, e; ⅣA and ⅣB were 2.30, 8.48, 4.28, 2.77, 4.46, 5.68 and 0.75 (mg/kg)respectively.
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