Novel synthetic method and analgesic activity of tepoxalin

Tepoxalin is a potent inhibitor of both the cyclooxygenase and lipoxygenase pathways of the  arachidonic acid cascade, as well as a potent anti-inflammatory and control-pain ( postoperation, arthritis et al) agent.  The new method about the use of novel synthesis reagents and the first using ionic liquid as reactive  solvent to synthesize tepoxalin were presented in this paper.  The ionic liquid can be easily recycled and   reused for several runs efficiently.  The analgesic activity of tepoxalin was detected by acetic acid test     on mice.  The analysis of variance showed that oral administration of tepoxalin could significantly inhibit  the number of writhing response within 1 hour and prolong the latent time in a dose dependent manner as compared with CMC control group (P < 0.05).  At the same time, tepoxalin had the same analgesic activity as diclofenac sodium.