Synthesis, structure characterization and anti-tumor activity of lanthanide complex Ln［(Phen)₂(5-Fu)₃(NO₃)］(NO₃)₂

AimTo study the biochemistry of lanthanides, the cooperative action of inorganic and organic anti-tumor drugs. MethodsA series of rare earth complexes were synthesized with Ln(NO₃)₃·6H₂O, Phen and 5-Fu. Their anti-tumor activity was measured by the improved MTT, SRB methods. ResultsThe formula of complex Ln［(Phen)₂(5-Fu)₃(NO₃)］(NO₃)₂ (Ln=Y, La, Ce, Sm, Gd, Dy, Er; Phen=1,10-phenanthroline; 5-Fu=fluorouracil) was characterized by elemental analyses, molar conductivity, IR, TGA, and ¹³C NMR spectra. The preliminary biological activity studies indicated that Lanthanide complex has strong anti-tumor activity in vitro. ConclusionThe complex might have anti-tumor cooperation action.