Articles in press have been peer-reviewed and accepted, which are not yet assigned to volumes /issues, but are citable by Digital Object Identifier (DOI).
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AI-integrated microfluidics for drug screening: From single cell to organ-on-a-chip
Hongyun Yin, Zheyu Li, Zinuo Shen, Shiying Wang, Na Du, Shibo Cheng, Jie Zhou, Yutao Li, Yanwei Jia, Ying Li,
2026, 16(3):1175-1200. DOI:10.1016/j.apsb.2026.01.001
Abstract
A review of recent advances in generative artificial intelligence models for biomolecular sciences
Jian Jiang, Daixin Li, Guilin Wang, Nicole Hayes, Yazhou Shi, Huahai Qiu, Bengong Zhang, Tianshou Zhou, Guo-Wei Wei,
2026, 16(3):1201-1218. DOI:10.1016/j.apsb.2025.12.012
Abstract
PhenoModel: A multimodal phenotypic drug design foundation model for discovering novel potential inhibitors of multiple cancer cells
Shihang Wang, Qilei Han, Weichen Qin, Lin Wang, Junhong Yuan, Fengyu Cai, Yiqun Zhao, Pengxuan Ren, Yunze Zhang, Yilin Tang, Ruifeng Li, Zongquan Li, Wenchao Zhang, Shenghua Gao, Fang Bai,
2026, 16(3):1219-1232. DOI:10.1016/j.apsb.2025.09.036
Abstract
TeroACT: A terpenoid bioactivity landscape and discovery platform
XiaoJuan Shen, Shijia Yan, Xu Kang, Kangwei Xu, Yongxing Jian, Tao Zeng, Guohui Wan, Ruibo Wu,
2026, 16(3):1233-1249. DOI:10.1016/j.apsb.2025.12.036
Abstract
Liver-pancreas communication in disease and drug development
Yan Jia, Qingtian Zhu, Qiong Pan, Guotao Lu, Jia Xiao,
2026, 16(3):1250-1271. DOI:10.1016/j.apsb.2026.01.018
Abstract
Targeting immunosuppressive network in glioblastoma: Emerging strategies to overcome immunodeficiency and enhance therapeutic efficacy
Songlei Zhou, Xiaokun Zhang, Jiayi Lin, Fenfen Ma, Hongzhuan Chen, Jun Chen, Xin Luan,
2026, 16(3):1272-1291. DOI:10.1016/j.apsb.2026.01.015
Abstract
Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities
Yuning Shi, Dazhi Feng, Jieya Zhou, Lihua Liu, Xinnan Li, Zhenwei Yuan, Jianbing Wu, Hong Yao,
2026, 16(3):1292-1335. DOI:10.1016/j.apsb.2025.12.010
Abstract
Tuning mechanical softness as a design principle in drug delivery: A biomechanical perspective
Kangyuan Qi, Shasha Zhang, Xinying Bi, Zhiping Zhang, Conglian Yang,
2026, 16(3):1336-1367. DOI:10.1016/j.apsb.2025.11.037
Abstract
Bacterial extracellular vesicles as bioactive nanocarriers for wound treatment
Yejiao Shi, Zelin Zheng, Yuting Li, Yirong Wang, Helena S. Azevedo, Xi Liu, Cuiping Zhang, Honggang Hu,
2026, 16(3):1368-1387. DOI:10.1016/j.apsb.2026.01.007
Abstract
Membrane-derived biomimetic nanovesicles in anti-tumor immunotherapy: Advances and outlook
Xianlu Zhang, Hongwei Jing, Yiyang Wang, Siyu Mu, Xia Wang, Haoyuan Zheng, Yiming Chen, Kaiyuan Wang, Jin Sun, Jianbin Bi, Gejun Zhang,
2026, 16(3):1388-1420. DOI:10.1016/j.apsb.2026.01.019
Abstract
Metal-polyphenol network-based multifunctional materials for tumor therapy: Intrinsic properties, advances, and applications
Chen Ma, Qian Xu, Lingwen Ding, Xinya Liu, Junkai Cheng, Yiman Wang, Lu Liu, Jiaqi Xian, Jian Gu, Phuong-Thao Tran, Qin Wang, Shuai Wang, Fen-Er Chen,
2026, 16(3):1421-1448. DOI:10.1016/j.apsb.2025.11.038
Abstract
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mutant leukemia
Huijing Wang, Fengyu Jiang, An Pan, Chenlong Jin, Yangyang Xue, Wenjie Liu, Renjun Gu, Yanyu Zhou, Qiuhong Shen, Tonghui Ma, Xiaoxuan Yu,
2026, 16(3):1449-1465. DOI:10.1016/j.apsb.2025.12.039
Abstract
Paeoniflorin alleviates hypobaric hypoxia-triggered lung injury through targeting MEK2 to modulate ERK2-SGK1 signaling
Zhenhui Wu, Yihao Wang, Renjie Wang, Rong Gao, Shubei Li, Bodan Tu, Xiubing Yin, Maoxing Li, Wei Zhou, Huanhua Xu, Zhenfeng Wu, Zengchun Ma, Xianglin Tang, Chengrong Xiao, Yue Gao,
2026, 16(3):1466-1488. DOI:10.1016/j.apsb.2025.12.024
Abstract
Identification of a small-molecule targeting PLAGL2 DNA-binding domain inhibits extracellular matrix formation and enhances lenvatinib sensitivity in hepatocellular carcinoma
Weiwei Hu, Jiaping Ni, Shufang Zheng, Xiaohui Wei, Dongqing Zhai, Jinglin Qi, Xinqi Ye, Mingyin Lu, Hanrui Bian, Jintong Li, Yumeng Shen, Jingwei Jiang, Weijun Zhao, Xueqing Shao, Shihao Xu, Xuewu Liang, Hong Liu, Yong Yang,
2026, 16(3):1489-1509. DOI:10.1016/j.apsb.2025.12.016
Abstract
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3
Nanxuan Luo, Yijie Xiao, Yile Zhai, Jie Li, Lijie Lv, Houhua Yin, Fang Lin, Biwen Wan, Ke Zhang, Junchi Hu, Junyan Liu, Yongjun Dang, Yi He, Yahui Zhao, Zhe Zhang, Shenyou Nie, Hai-Xin Yuan,
2026, 16(3):1510-1529. DOI:10.1016/j.apsb.2025.11.004
Abstract
Mechanistic insights into ligand selectivity in μ- and δ-opioid receptors beyond the “message-address” conceptual framework
Xin Zhang, Hongyan Song, Ruofan Chen, Xinran Kong, Jin Wang, Xinghua Li, Ye Yu,
2026, 16(3):1530-1549. DOI:10.1016/j.apsb.2025.11.039
Abstract
Flavescensines A-L: Novel azaspiro[4.4] heterodimeric alkaloids from Sophora flavescens protect against liver injury by inhibiting DUSP2-mediated mitochondrial apoptosis
Xin Lian, Jianshuang Jiang, Yanan Yang, Ziming Feng, Xu Zhang, Xiang Yuan, Peicheng Zhang,
2026, 16(3):1550-1567. DOI:10.1016/j.apsb.2025.12.019
Abstract
The transcriptional regulatory network involved in periderm-specific tanshinones biosynthesis in Salvia miltiorrhiza root
Yajing Li, Peng Di, Yinan Zou, Xiao Li, Ke Zhang, Jing Wang, Yun Wang, Shi Qiu, Jingfu Tan, Weixu Chen, Bo Li, Tingzhao Li, Lei Zhang, Ying Xiao, Wansheng Chen, Junfeng Chen,
2026, 16(3):1568-1583. DOI:10.1016/j.apsb.2025.12.018
Abstract
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy
Chaoyan Yao, Lei Wang, Weidong Liu, Ning Shi, Ziling Liao, Yuxuan Fu, Jinhao Ouyang, Xuan Lei, Qianping Huang, Siyu Li, Yihua Zhouyang, Pinnan Zhao, Jie Wang, Hongjuan Xu, Wenhu Zhou, Xingjun Jiang, Xiang Gao, Caiping Ren, Longlong Luo,
2026, 16(3):1584-1604. DOI:10.1016/j.apsb.2025.10.007
Abstract
Dichotomous role of CD47-SIRPα axis: Leveraging opposing functions in phagocytic resistance and transport assistance for enhanced nanocarrier biocompatibility and tumor penetration
Xuehui Duan, Yixuan Tang, Zhongjie Tang, Yan Du, Xinlei Chu, XinLong Liu, Zhanyan Liu, Kun Zhao, Wei Xu, Chong Li,
2026, 16(3):1605-1624. DOI:10.1016/j.apsb.2025.11.013
Abstract
Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccine via increasing transcytosis of antigen and submucosal dendritic cell recruitment
Afeng Yang, Chen Zhang, Aihua Wu, Jiaojiao Xu, Hongzheng Lin, Zhe Li, Tingting Li, Yunlu Li, Ningshao Xia, Xunlong Shi, Tianying Zhang, Wei Lu,
2026, 16(3):1625-1642. DOI:10.1016/j.apsb.2025.12.021
Abstract
Multivalent sulphur-modified biosilica nanostructures for bacterial enteritis therapy
Tongyi Zhao, Xiaoxi Fan, Haijia Hou, Miao Xu, Yuman Sun, Jingjie Sun, Ziwei Hao, Xuchun Chen, Long He, Xuting Zheng, Heran Li, Jiali Han,
2026, 16(3):1643-1661. DOI:10.1016/j.apsb.2025.12.045
Abstract
Heterocyclic modified paclitaxel prodrug nanoassemblies for stimuli-responsive delivery via lysosomal escape
Mingyang Han, Hezhen Xu, Jun Yuan, Wenxiao Li, Hao Zhang, Hongkai Fang, Zhiyu Kuang, Yuanhao Yu, Danping Wang, Zhenzhen Zhao, Cong Luo, Bingjun Sun, Jin Sun,
2026, 16(3):1662-1675. DOI:10.1016/j.apsb.2026.01.017
Abstract
Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide
Junrong Wu, Guangman Cui, Zhousheng Lin, Wanmei Lin, Yaqing Zhang, Tianhang Zhou, Ping He, Yunjiao Zhang, Guangyu Yao,
2026, 16(3):1676-1695. DOI:10.1016/j.apsb.2025.12.015
Abstract
Extracellular vesicles-derived hybrid biomimetic nanoplatforms camouflaged Golgi apparatus-targeted aggregation induced emission photosensitizer to elicit pyroptosis and immunogenic cell death for efficient antitumor photoimmunotherapy
Xing Zhao, Xi Wu, Ranran Shang, Haitao Dou, Huachao Chen, Ninghua Tan,
2026, 16(3):1696-1716. DOI:10.1016/j.apsb.2025.11.010
Abstract
Exploiting eNOS activation to achieve tumor vascular normalization via endothelial transcytosis of lipid nanoparticles
Huisong Hao, Yunfei Yi, Yanan Fu, Shengjie Sun, Zhangwen Peng, Jia Tang, Yixuan Fang, Shihao Zhuang, Yaqi Ouyang, Tianqi Wang, Meiying Wu,
2026, 16(3):1717-1732. DOI:10.1016/j.apsb.2025.11.040
Abstract
Ferroptosis-based nano-assembly enhanced breast cancer therapy by inhibiting intratumor bacteria
Yao Qi, Yue Qiu, Yuting Zhang, Liang Zhang, Hui Xiong, Jing Yao,
2026, 16(3):1733-1746. DOI:10.1016/j.apsb.2026.01.027
Abstract
bHLH130 mediates gibberellin signaling to regulate tanshinone biosynthesis in Salvia miltiorrhiza
Haizheng Yu, Ruiyang Yao, Sixue Zhang, Yongxing Chen, Caiyan Liang, Yijing Liu, Wenrui Li, Bingcong Xing, Dongfeng Yang, Lei Zhang,
2026, 16(3):1747-1761. DOI:10.1016/j.apsb.2025.11.041
Abstract
Aptamers targeting respiratory syncytial virus showed high inhibitory activity by blocking the G protein
Ge Yang, Guangyu Jiang, Xintao Lian, Boming Cui, Shuo Wu, Huiqiang Wang, Haiyan Yan, Kun Wang, Rongmei Gao, Feng Qu, Jiandong Jiang, Yuhuan Li,
2026, 16(3):1762-1768. DOI:10.1016/j.apsb.2025.12.027
Abstract
Single-cell RNA sequencing-guided drug discovery to alleviate radiotherapy-induced esophageal toxicity
Wenling Tu, Hangfeng Liu, Hongyu Lin, Jinkang Zhang, Tang Feng, Zhenyu Ding, Qing Li, Yuhong Shi, Zehua Zhou, Shuyu Zhang,
2026, 16(3):1769-1772. DOI:10.1016/j.apsb.2025.12.038
Abstract
Multi-omics-based identification of METTL11B as a novel biomarker in esophageal squamous cell carcinoma
Wenke Jin, Hongyao Li, Yanmei Chen, Wei Wang, Rui Liu, Ning Li, Yong Yuan,
2026, 16(3):1773-1778. DOI:10.1016/j.apsb.2026.01.025
Abstract
Distinctive molecular architectures of Gq- and Gi-coupled GLP-1 receptors
Qingtong Zhou, Jie Li, Yao Zhang, Xiaoqing Cai, Wei Han, Dehua Yang, Ming-Wei Wang,
2026, 16(3):1779-1785. DOI:10.1016/j.apsb.2026.01.023
Abstract
Phosphatases: An undervalued class of antitumor drug targets
Mei Wang, Peng Zhan, Yuning Song,
2026, 16(3):1786-1789. DOI:10.1016/j.apsb.2025.11.021
Abstract
Targeting MEK2 by paeoniflorin: Mechanism underlying its protection against hypobaric hypoxia-induced lung injury
Boli Zhang,
2026, 16(3):1790-1792. DOI:10.1016/j.apsb.2026.03.001
Abstract
Leveraging vascular normalization via eNOS activation to enhance the efficacy of PD-L1 blockade
Yang Zhou, Huile Gao,
2026, 16(3):1793-1794. DOI:10.1016/j.apsb.2026.02.025
Abstract
RDYH58 functionalized exosomes homing muscle fibroblasts for delivery of siRNA targeting FKBP10: A novel therapeutic strategy for idiopathic pulmonary fibrosis
Mengqin Guo, Wenhao Wang, Chuanbin Wu, Zhengwei Huang,
2026, 16(3):1795-1796. DOI:10.1016/j.apsb.2026.01.022
Abstract
Integrating Chinese medicine and intermittent fasting: A promising approach for treating diabetic vascular calcification
Zhixiu Lin,
2026, 16(3):1797-1799. DOI:10.1016/j.apsb.2026.01.004
Abstract

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