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Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications
Ling Zou, Minru Liao, Yongqi Zhen, Shiou Zhu, Xiya Chen, Jin Zhang, Yue Hao, Bo Liu,
2022, 12(10):3743-3782. DOI:10.1016/j.apsb.2022.06.004
Abstract
Carbohydrate-based drugs launched during 2000-2021
Xin Cao, Xiaojing Du, Heng Jiao, Quanlin An, Ruoxue Chen, Pengfei Fang, Jing Wang, Biao Yu,
2022, 12(10):3783-3821. DOI:10.1016/j.apsb.2022.05.020
Abstract
Extracellular vesicles: Emerging tools as therapeutic agent carriers
Shan Liu, Xue Wu, Sutapa Chandra, Christopher Lyon, Bo Ning, Li jiang, Jia Fan, Tony Y. Hu,
2022, 12(10):3822-3842. DOI:10.1016/j.apsb.2022.05.002
Abstract
Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase
Xiaoqing Zhou, Shaoyang Zhao, Tingting Liu, Lu Yao, Meimei Zhao, Xiaoming Ye, Xiaowen Zhang, Qiang Guo, Pengfei Tu, Kewu Zeng,
2022, 12(10):3843-3860. DOI:10.1016/j.apsb.2022.06.013
Abstract
Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78–FOXM1–KIF20A pathway
Jinlian Wei, Xin Chen, Yongyun Li, Ruoxi Li, Keting Bao, Liang Liao, Yuqing Xie, Tiannuo Yang, Jin Zhu, Fei Mao, Shuaishuai Ni, Renbing Jia, Xiaofang Xu, Jian Li,
2022, 12(10):3861-3876. DOI:10.1016/j.apsb.2022.05.021
Abstract
Gli1 promotes epithelial–mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability
Xueping Lei, Zhan Li, Yihang Zhong, Songpei Li, Jiacong Chen, Yuanyu Ke, Sha Lv, Lijuan Huang, Qianrong Pan, Lixin Zhao, Xiangyu Yang, Zisheng Chen, Qiudi Deng, Xiyong Yu,
2022, 12(10):3877-3890. DOI:10.1016/j.apsb.2022.05.024
Abstract
Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease
Ping Bai, Prasenjit Mondal, Frederick A. Bagdasarian, Nisha Rani, Yan Liu, Ashley Gomm, Darcy R. Tocci, Se Hoon Choi, Hsiao-Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang,
2022, 12(10):3891-3904. DOI:10.1016/j.apsb.2022.05.017
Abstract
Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts
Aneesh V. Karkhanis, Gopalakrishnan Venkatesan, Ryuichi Kambayashi, Jacqueline Wen Hui Leow, Marcus Qingrui Han, Hiroko Izumi-Nakaseko, Ai Goto, Jeremy Kah Sheng Pang, Boon Seng Soh, Pipin Kojodjojo, Atsushi Sugiyama, Eric Chun Yong Chan,
2022, 12(10):3905-3923. DOI:10.1016/j.apsb.2022.03.008
Abstract
Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease
Bo Qin, Gregory B. Craven, Pengjiao Hou, Julian Chesti, Xinran Lu, Emma S. Child, Rhodri M.L. Morgan, Wenchao Niu, Lina Zhao, Alan Armstrong, David J. Mann, Sheng Cui,
2022, 12(10):3924-3933. DOI:10.1016/j.apsb.2022.06.002
Abstract
Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy
Xuan Yang, Yalong Wang, Junke Zhao, Hehui Rong, Yujun Chen, Mengting Xiong, Xiaoxing Ye, Shihui Yu, Haiyan Hu,
2022, 12(10):3934-3951. DOI:10.1016/j.apsb.2022.06.009
Abstract
Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma
Leyang Wu, Lin Li, Shufeng Li, Lina Liu, Wenjie Xin, Chenyang Li, Xingpeng Yin, Xuebo Xu, Feifei Bao, Zichun Hua,
2022, 12(10):3952-3971. DOI:10.1016/j.apsb.2022.05.006
Abstract
Ionic co-aggregates (ICAs) based oral drug delivery: Solubilization and permeability improvement
Xianzi Zheng, Zhezheng Fang, Weizi Huang, Jianping Qi, Xiaochun Dong, Weili Zhao, Wei Wu, Yi Lu,
2022, 12(10):3972-3985. DOI:10.1016/j.apsb.2022.04.011
Abstract
Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation
Qian Hu, Jiaqi Yao, Xiajia Wu, Juan Li, Guixiang Li, Wenfu Tang, Jingping Liu, Meihua Wan,
2022, 12(10):3986-4003. DOI:10.1016/j.apsb.2021.10.008
Abstract
Discovery of novel heteroaryl alkynes for highly potent KITD816V cells inhibition to treat gastrointestinal stromal tumors
Zhicheng Xie, Lin Li, Yihao Guo, Mi Zhang, Taiwen Chen, Yongpeng Li, Xin Li, Xi Zhu, Yu Zhang, Liguang Lou, Youhong Hu,
2022, 12(10):4004-4007. DOI:10.1016/j.apsb.2022.07.015
Abstract
Nature-inspired supramolecular assemblies for precise biomedical imaging and therapy
Yamin Liu, Qiyue Wang, Fangyuan Li, Daishun Ling,
2022, 12(10):4008-4010. DOI:10.1016/j.apsb.2022.06.014
Abstract

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