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Targeting the blood–brain barrier to delay aging-accompanied neurological diseases by modulating gut microbiota, circadian rhythms, and their interplays
Yanping Wang, Weihong Du, Xiaoyan Hu, Xin Yu, Chun Guo, Xinchun Jin, Wei Wang,
2023, 13(12):4667-4687. DOI:10.1016/j.apsb.2023.08.009
Abstract
Targeting autophagy and beyond: Deconvoluting the complexity of Beclin-1 from biological function to cancer therapy
Jing Ye, Jin Zhang, Yanghui Zhu, Lian Wang, Xian Jiang, Bo Liu, Gu He,
2023, 13(12):4688-4714. DOI:10.1016/j.apsb.2023.08.008
Abstract
Emerging drug design strategies in anti-influenza drug discovery
Chuanfeng Liu, Lide Hu, Guanyu Dong, Ying Zhang, Edeildo Ferreira da Silva-Júnior, Xinyong Liu, Luis Menéndez-Arias, Peng Zhan,
2023, 13(12):4715-4732. DOI:10.1016/j.apsb.2023.08.010
Abstract
ACAT1 deficiency in myeloid cells promotes glioblastoma progression by enhancing the accumulation of myeloid-derived suppressor cells
Mingjin Wang, Weida Wang, Shen You, Zhenyan Hou, Ming Ji, Nina Xue, Tingting Du, Xiaoguang Chen, Jing Jin,
2023, 13(12):4733-4747. DOI:10.1016/j.apsb.2023.09.005
Abstract
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood–brain barrier and exhibits potent activity against glioblastoma
Yingqiang Liu, Zhengsheng Zhan, Zhuang Kang, Mengyuan Li, Yongcong Lv, Shenglan Li, Linjiang Tong, Fang Feng, Yan Li, Mengge Zhang, Yaping Xue, Yi Chen, Tao Zhang, Peiran Song, Yi Su, Yanyan Shen, Yiming Sun, Xinying Yang, Yi Chen, Shanyan Yao, Hanyu Yang, Caixia Wang, Meiyu Geng, Wenbin Li, Wenhu Duan, Hua Xie, Jian Ding,
2023, 13(12):4748-4764. DOI:10.1016/j.apsb.2023.09.009
Abstract
Non-canonical STING–PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response
Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, Yunjia Zhang, Ruigong Zhu, Jiajing Chen, Jiaming Gu, Quanwen Yin, Hong Jiang, Xuan Wu, Xian Ji, Xin Tang, Mengdie Dong, Qingguo Li, Yuanqing Gao, Hongshan Chen,
2023, 13(12):4765-4784. DOI:10.1016/j.apsb.2023.08.015
Abstract
Macrophage LMO7 deficiency facilitates inflammatory injury via metabolic-epigenetic reprogramming
Shixin Duan, Xinyi Lou, Shiyi Chen, Hongchao Jiang, Dongxin Chen, Rui Yin, Mengkai Li, Yuseng Gou, Wenjuan Zhao, Lei Sun, Feng Qian,
2023, 13(12):4785-4800. DOI:10.1016/j.apsb.2023.09.012
Abstract
Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression- and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner
Kaikai Zhang, Lijian Chen, Jianzheng Yang, Jiali Liu, Jiahao Li, Yi Liu, Xiuwen Li, Long Chen, Clare Hsu, Jiahao Zeng, Xiaoli Xie, Qi Wang,
2023, 13(12):4801-4822. DOI:10.1016/j.apsb.2023.09.010
Abstract
TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNA-PKcs cytosolic retention and DNA damage
Wenjun Yu, Haixia Xu, Zhe Sun, Yuxin Du, Shiqun Sun, Miyesaier Abudureyimu, Mengjiao Zhang, Jun Tao, Junbo Ge, Jun Ren, Yingmei Zhang,
2023, 13(12):4823-4839. DOI:10.1016/j.apsb.2023.09.008
Abstract
ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie,
2023, 13(12):4840-4855. DOI:10.1016/j.apsb.2023.07.006
Abstract
Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector (VSVMT) in golden syrian hamster
Yong Ke, En Zhang, Jianming Guo, Xiaoxiao Zhang, Lei Wang, Duo Chen, Xinkui Fang, Jianwei Zhu, Feng Li, Tao Sun, Baohong Zhang,
2023, 13(12):4856-4874. DOI:10.1016/j.apsb.2023.08.023
Abstract
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis
Wenjing Yu, Yuehuai Hu, Zhiping Liu, Kaiteng Guo, Dinghu Ma, Mingxia Peng, Yuemei Wang, Jing Zhang, Xiaolei Zhang, Panxia Wang, Jiguo Zhang, Peiqing Liu, Jing Lu,
2023, 13(12):4875-4892. DOI:10.1016/j.apsb.2023.08.016
Abstract
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors
Youchao Deng, Xiaosheng Song, Iredia D. Iyamu, Aiping Dong, Jinrong Min, Rong Huang,
2023, 13(12):4893-4905. DOI:10.1016/j.apsb.2023.07.022
Abstract
Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility
Li-Min Zhao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen,
2023, 13(12):4906-4917. DOI:10.1016/j.apsb.2023.07.008
Abstract
Structure-based drug discovery of novel fused-pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
Feifei Fang, Yang Dai, Hao Wang, Yinchun Ji, Xuewu Liang, Xia Peng, Jiyuan Li, Yangrong Zhao, Chunpu Li, Danyi Wang, Yazhou Li, Dong Zhang, Dan Zhang, Meiyu Geng, Hong Liu, Jing Ai, Yu Zhou,
2023, 13(12):4918-4933. DOI:10.1016/j.apsb.2023.10.002
Abstract
Discovery of a highly potent and orally available importin-β1 inhibitor that overcomes enzalutamide-resistance in advanced prostate cancer
Jia-Luo Huang, Xue-Long Yan, Dong Huang, Lu Gan, Huahua Gao, Run-Zhu Fan, Shen Li, Fang-Yu Yuan, Xinying Zhu, Gui-Hua Tang, Hong-Wu Chen, Junjian Wang, Sheng Yin,
2023, 13(12):4934-4944. DOI:10.1016/j.apsb.2023.07.017
Abstract
Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection
Xintong Zhao, Jing Feng, Jie Zhang, Zunsheng Han, Yuhua Hu, Hui-Hui Shao, Tianlei Li, Jie Xia, Kangfan Lei, Weiping Wang, Fangfang Lai, Yuan Lin, Bo Liu, Kun Zhang, Chi Zhang, Qingyun Yang, Xinyu Luo, Hanyilan Zhang, Chuang Li, Wenxuan Zhang, Song Wu,
2023, 13(12):4945-4962. DOI:10.1016/j.apsb.2023.08.030
Abstract
Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer
Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo, Chune Dong, Hai-Bing Zhou,
2023, 13(12):4963-4982. DOI:10.1016/j.apsb.2023.05.005
Abstract
Development of exosome membrane materials-fused microbubbles for enhanced stability and efficient drug delivery of ultrasound contrast agent
Yongho Jang, Jeehun Park, Pilsu Kim, Eun-Joo Park, Hyungjin Sun, Yujin Baek, Jaehun Jung, Tai-kyong Song, Junsang Doh, Hyuncheol Kim,
2023, 13(12):4983-4998. DOI:10.1016/j.apsb.2023.08.022
Abstract
Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration
Qiaozi Wang, Yanan Song, Jinfeng Gao, Qiyu Li, Jing Chen, Yifang Xie, Zhengmin Wang, Haipeng Tan, Hongbo Yang, Ning Zhang, Juying Qian, Zhiqing Pang, Zheyong Huang, Junbo Ge,
2023, 13(12):4999-5015. DOI:10.1016/j.apsb.2023.08.021
Abstract
Reactive oxygen species and nitric oxide scavenging nanoparticles alleviating rheumatoid arthritis through adjusting the seeds and growing soils
Peng Hua, Ruifeng Liang, Yanbei Tu, Yuying Yin, Man-Kay Law, Meiwan Chen,
2023, 13(12):5016-5029. DOI:10.1016/j.apsb.2023.07.021
Abstract
Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity
Huaqing Jing, Yingzi Ren, Yue Zhou, Min Xu, Sona Krizkova, Zbynek Heger, Qiang Lu, Siyu Wang, Xiaoyang Liang, Vojtech Adam, Nan Li,
2023, 13(12):5030-5047. DOI:10.1016/j.apsb.2023.08.020
Abstract
Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy
Xiaodi Liu, Qi Zhang, Yixia Liang, Shiyu Xiong, Yan Cai, Jincheng Cao, Yanni Xu, Xiaolin Xu, Ye Wu, Qiang Lu, Xiaoding Xu, Baoming Luo,
2023, 13(12):5048-5059. DOI:10.1016/j.apsb.2023.07.012
Abstract
Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation
Yitong Liu, Guiyang Xia, Yingyi Chen, Huan Xia, Junji Xu, Lijia Guo, Sheng Lin, Yi Liu,
2023, 13(12):5060-5073. DOI:10.1016/j.apsb.2023.05.032
Abstract
Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy
Lina Guo, Jinsong Ding, Wenhu Zhou,
2023, 13(12):5074-5090. DOI:10.1016/j.apsb.2023.08.028
Abstract
An injectable signal-amplifying device elicits a specific immune response against malignant glioblastoma
Qiujun Qiu, Sunhui Chen, Huining He, Jixiang Chen, Xinyi Ding, Dongdong Wang, Jiangang Yang, Pengcheng Guo, Yang Li, Jisu Kim, Jianyong Sheng, Chao Gao, Bo Yin, Shihao Zheng, Jianxin Wang,
2023, 13(12):5091-5106. DOI:10.1016/j.apsb.2023.06.010
Abstract
Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment
Yan Zhang, Haiyun Zhang, Faquan Zhao, Zhengping Jiang, Yuanlu Cui, Meitong Ou, Lin Mei, Qiangsong Wang,
2023, 13(12):5107-5120. DOI:10.1016/j.apsb.2023.06.011
Abstract
Orange-derived extracellular vesicles nanodrugs for efficient treatment of ovarian cancer assisted by transcytosis effect
Feng Long, Yao Pan, Jinheng Li, Suinan Sha, Xiubo Shi, Haoyan Guo, Chuanqing Huang, Qian Xiao, Chao Fan, Xingmei Zhang, Jun-Bing Fan, Ying Wang,
2023, 13(12):5121-5134. DOI:10.1016/j.apsb.2023.04.006
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica