column
Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases
Junjun Wu, Hong Wang, Pu Gao, Songying Ouyang,
2024, 14(10):4195-4227. DOI:10.1016/j.apsb.2024.06.026
Abstract
A systematic, updated review of Xuezhikang, a domestically developed lipid-lowering drug, in the application of cardiovascular diseases
Cheng Yang, Yongjian Wu, Jie Qian, Jian-Jun Li,
2024, 14(10):4228-4242. DOI:10.1016/j.apsb.2024.05.011
Abstract
Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities
Zeyu Han, Zekai Shen, Jiayue Pei, Qidong You, Qiuyue Zhang, Lei Wang,
2024, 14(10):4243-4265. DOI:10.1016/j.apsb.2024.06.019
Abstract
Characteristic roadmap of linker governs the rational design of PROTACs
Yawen Dong, Tingting Ma, Ting Xu, Zhangyan Feng, Yonggui Li, Lingling Song, Xiaojun Yao, Charles R. Ashby, Ge-Fei Hao,
2024, 14(10):4266-4295. DOI:10.1016/j.apsb.2024.04.007
Abstract
Genome-wide pan-GPCR cell libraries accelerate drug discovery
Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen,
2024, 14(10):4296-4311. DOI:10.1016/j.apsb.2024.06.023
Abstract
Demethylzeylasteral induces PD-L1 ubiquitin—proteasome degradation and promotes antitumor immunity via targeting USP22
Yanyan Zhang, Yun Huang, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang, Sanhong Liu, Weidong Zhang,
2024, 14(10):4312-4328. DOI:10.1016/j.apsb.2024.08.004
Abstract
Ribonucleotide reductase small subunit M2 promotes the proliferation of esophageal squamous cell carcinoma cells via HuR-mediated mRNA stabilization
Jing Zhang, Qiong Wu, Yifei Xie, Feng Li, Huifang Wei, Yanan Jiang, Yan Qiao, Yinhua Li, Yanan Sun, Han Huang, Mengmeng Ge, Dengyun Zhao, Zigang Dong, Kangdong Liu,
2024, 14(10):4329-4344. DOI:10.1016/j.apsb.2024.07.022
Abstract
Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein
Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat, Marquiza Sablón Carrazana, Roberto Menéndez Soto del Valle, Tangui Maurice, Chryslaine Rodríguez-Tanty,
2024, 14(10):4345-4359. DOI:10.1016/j.apsb.2024.06.013
Abstract
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses
Li Yin, Enming Zhang, Tianqi Mao, Yifan Zhu, Shurui Ni, Yehong Li, Chunxiao Liu, Yafei Fang, Kexin Ni, Yuhe Lu, Huanqiu Li, Mengze Zhou, Qinghua Hu,
2024, 14(10):4360-4377. DOI:10.1016/j.apsb.2024.06.008
Abstract
PKCα inhibitors promote breast cancer immune evasion by maintaining PD-L1 stability
Jiaojiao Yu, Yujin Xiang, Yuzhen Gao, Shan Chang, Ren Kong, Xiaoxi Lv, Jinmei Yu, Yunjie Jin, Chenxi Li, Yiran Ma, Zhenhe Wang, Jichao Zhou, Hongyu Yuan, Shuang Shang, Fang Hua, Xiaowei Zhang, Bing Cui, Pingping Li,
2024, 14(10):4378-4395. DOI:10.1016/j.apsb.2024.08.003
Abstract
Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma
Dan Han, Qiannan Ma, Petek Ballar, Chunyang Zhang, Min Dai, Xiaoyuan Luo, Jiong Gu, Chuansheng Wei, Panhui Guo, Lulu Zeng, Min Hu, Can Jiang, Yanyan Liang, Yanyan Wang, Chao Hou, Xian Wang, Lijie Feng, Yujun Shen, Yuxian Shen, Xiangpeng Hu,
2024, 14(10):4396-4412. DOI:10.1016/j.apsb.2024.05.001
Abstract
PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity
Bin Chen, Cheng Cheng, Yunhao Wu, Siyu Li, Mo Han, Le Zhen, Ying Peng, Suhan Guo, Kaidi Shen, Xia Gao, Renjie Chai, Guangji Wang, Fang Zhou,
2024, 14(10):4413-4430. DOI:10.1016/j.apsb.2024.05.024
Abstract
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
Qinghua Wang, Tingting Du, Zhihui Zhang, Qingyang Zhang, Jie Zhang, Wenbin Li, Jian-Dong Jiang, Xiaoguang Chen, Hai-Yu Hu,
2024, 14(10):4431-4442. DOI:10.1016/j.apsb.2024.07.005
Abstract
Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach
Jianguo Song, Ruili Huang, Jialiao Cai, Zhenlong Wu, Lijun Hu, Wanyang Sun, Xiaojun Huang, Rongrong He, Wei Tang, Wencai Ye, Ying Wang,
2024, 14(10):4443-4460. DOI:10.1016/j.apsb.2024.04.031
Abstract
Spatial metabolomics highlights metabolic reprogramming in acute myeloid leukemia mice through creatine pathway
Yucheng Bao, Jing Qiao, Wenjie Gong, Ruihong Zhang, Yanting Zhou, Yinyin Xie, Yuan Xie, Jiuming He, Tong Yin,
2024, 14(10):4461-4477. DOI:10.1016/j.apsb.2024.07.004
Abstract
Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins
Yan Zhao, Haolin Jiang, Hang Chen, Jiazhen Yu, Luyao Wang, Wen Zhou, Juanjuan Du,
2024, 14(10):4478-4492. DOI:10.1016/j.apsb.2024.06.022
Abstract
Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity
Jingru Wang, Man Liu, Jingwen Wang, Zhuoyue Li, Zhenhan Feng, Meiqi Xu, Hui Wang, Hui Li, Zhantao Li, Jianming Yu, Junwei Liu, Qingchao Wei, Shuang Zhang, Xuan Zhang,
2024, 14(10):4493-4508. DOI:10.1016/j.apsb.2024.07.002
Abstract
Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer
Jiahui Zou, Xuyang Xing, Chao Teng, Qingling Zhao, Wei He, Xuri Wu, Yuanzheng Xia,
2024, 14(10):4509-4525. DOI:10.1016/j.apsb.2024.08.014
Abstract
Disease-derived circulating extracellular vesicle preconditioning: A promising strategy for precision mesenchymal stem cell therapy
Ke Lv, Tian Wu, Shuyun Liu, Peng Lou, Pingya Zhou, Yizhuo Wang, Xiyue Zhou, Shu Zhang, Dan Du, Yanrong Lu, Meihua Wan, Jingping Liu,
2024, 14(10):4526-4543. DOI:10.1016/j.apsb.2024.06.027
Abstract
Choroid plexus CCL2-CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus
Qiguang Wang, Fei Liu, Yue Li, Huan Zhang, Xin Qi, Ke Wu, Yi Zhang, Shenglan You, Wenke Liu, Xuhui Hui, Hanmei Li, Lei Zhu, Huile Gao, Jian Cheng,
2024, 14(10):4544-4559. DOI:10.1016/j.apsb.2024.06.020
Abstract
A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
Lai Wang, Haoyuan Yin, Jiao Jiang, Qilin Li, Changxing Gao, Wenrui Li, Bo Zhang, Yue Xin, Hongyang Li, Ming Zhao, Qianjin Lu,
2024, 14(10):4560-4576. DOI:10.1016/j.apsb.2024.06.024
Abstract
Simultaneous enhancement of cellular and humoral immunity by the lymph node-targeted cholesterolized TLR7 agonist liposomes
Dandan Wan, Ziyi Bai, Yu Zhang, Li Chen, Haiying Que, Tianxia Lan, Weiqi Hong, Jiayu Huang, Cai He, Yuquan Wei, Qiang Pu, Xiawei Wei,
2024, 14(10):4577-4590. DOI:10.1016/j.apsb.2024.06.006
Abstract
Modeling on in vivo disposition and cellular transportation of RNA lipid nanoparticles via quantum mechanics/physiologically-based pharmacokinetic approaches
Wei Wang, Shiwei Deng, Jinzhong Lin, Defang Ouyang,
2024, 14(10):4591-4607. DOI:10.1016/j.apsb.2024.06.011
Abstract
Engineering the microenvironment of P450s to enhance the production of diterpenoids in Saccharomyces cerevisiae
Yatian Cheng, Linglong Luo, Hao Tang, Jian Wang, Li Ren, Guanghong Cui, Yujun Zhao, Jinfu Tang, Ping Su, Yanan Wang, Yating Hu, Ying Ma, Juan Guo, Luqi Huang,
2024, 14(10):4608-4618. DOI:10.1016/j.apsb.2024.05.019
Abstract
Nanotechnology-based tumor metabolic reprogramming: Insights into nutrient-delivery and metabolism reactivation therapy
Xi Hu, Daishun Ling,
2024, 14(10):4619-4621. DOI:10.1016/j.apsb.2024.07.015
Abstract
RMC-7977, a highly selective inhibitor of the active RAS-GTP to treat pancreatic cancer
Ying-Qi Song, Qingjun Li, Chunquan Sheng,
2024, 14(10):4622-4624. DOI:10.1016/j.apsb.2024.07.014
Abstract
Inhibition of liver cholesterol synthesis by a diet-induced gut hormone
Xiabing Huang, Jianping Ye,
2024, 14(10):4625-4627. DOI:10.1016/j.apsb.2024.07.026
Abstract
ROS-degradable polythioketal urethane scaffold for porcine wound repair
Salim Ullah, Hong-Tao Xu, Jianliang Shen,
2024, 14(10):4628-4631. DOI:10.1016/j.apsb.2024.05.034
Abstract
Activating autophagy improves paclitaxel-induced peripheral neuropathy in chemotherapy
Jin Zhang, Yelan Huang, Xiaohan Sun, Xiya Chen, Xi Zhao, Chenqiu Ran, Bo Liu, Yue Hao,
2024, 14(10):4632-4636. DOI:10.1016/j.apsb.2024.08.010
Abstract