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Targeting RAF dimers in RAS mutant tumors: From biology to clinic
Huanhuan Yin, Qiulin Tang, Hongwei Xia, Feng Bi,
2024, 14(5):1895-1923. DOI:10.1016/j.apsb.2024.02.018
Abstract
Oligomerization of drug transporters: Forms, functions, and mechanisms
Chunxu Ni, Mei Hong,
2024, 14(5):1924-1938. DOI:10.1016/j.apsb.2024.01.007
Abstract
Bile acids and coronavirus disease 2019
Xiaoru Huang, Xuening Liu, Zijian Li,
2024, 14(5):1939-1950. DOI:10.1016/j.apsb.2024.02.011
Abstract
The inhibitory effect of adenosine on tumor adaptive immunity and intervention strategies
Longsheng Wang, Jie Zhang, Wenxin Zhang, Mingming Zheng, Hongjie Guo, Xiaohui Pan, Wen Li, Bo Yang, Ling Ding,
2024, 14(5):1951-1964. DOI:10.1016/j.apsb.2023.12.004
Abstract
Bispecific antibody drug conjugates: Making 1+1>2
Yilin Gu, Zhijia Wang, Yuxi Wang,
2024, 14(5):1965-1986. DOI:10.1016/j.apsb.2024.01.009
Abstract
Discovery of GluN2A subtype-selective N-methyl-D-aspartate (NMDA) receptor ligands
Liyang Jiang, Na Liu, Fabao Zhao, Boshi Huang, Dongwei Kang, Peng Zhan, Xinyong Liu,
2024, 14(5):1987-2005. DOI:10.1016/j.apsb.2024.01.004
Abstract
Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives
Bingwen Ding, Zhu Zhu, Cong Guo, Jiaxin Li, Yong Gan, Miaorong Yu,
2024, 14(5):2006-2025. DOI:10.1016/j.apsb.2024.02.019
Abstract
ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2-BECN1 interaction
Shiqiang Xu, Qilian Ma, Junwen Shen, Ningning Li, Shan Sun, Nana Wang, Yang Chen, Chunsheng Dong, Kin Yip Tam, Jochen H.M. Prehn, Hongfeng Wang, Zheng Ying,
2024, 14(5):2026-2038. DOI:10.1016/j.apsb.2024.02.004
Abstract
Exosomes derived from pulmonary metastatic sites enhance osteosarcoma lung metastasis by transferring the miR-194/215 cluster targeting MARCKS
Pei Yu, Yubao Han, Lulu Meng, Yanyuan Tian, Zhiwei Jin, Jun Luo, Chao Han, Wenjun Xu, Lingyi Kong, Chao Zhang,
2024, 14(5):2039-2056. DOI:10.1016/j.apsb.2024.01.016
Abstract
The raphe nuclei are the early lesion site of gastric α-synuclein propagation to the substantia nigra
Chenglu Zhang, Ruxue Bo, Tiantian Zhou, Naihong Chen, Yuhe Yuan,
2024, 14(5):2057-2076. DOI:10.1016/j.apsb.2024.01.015
Abstract
Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery
Cheng Qian, Yueke Zhou, Teng Zhang, Guanglu Dong, Mengyao Song, Yu Tang, Zhonghong Wei, Suyun Yu, Qiuhong Shen, Wenxing Chen, Jaesung P. Choi, Juming Yan, Chongjin Zhong, Li Wan, Jia Li, Aiyun Wang, Yin Lu, Yang Zhao,
2024, 14(5):2077-2096. DOI:10.1016/j.apsb.2024.02.003
Abstract
DDAH1 promotes neurogenesis and neural repair in cerebral ischemia
Qiming Gao, Pinfei Ni, Yilin Wang, Peiyun Huo, Xiaojie Zhang, Sihan Wang, Fuyao Xiao, Yixuan Li, Wei Feng, Juntao Yuan, Teng Zhang, Qiang Li, Boyu Fan, Yuhao Kan, Zhirui Li, Yimiao Qi, Junfei Xing, Zhenghong Yang, Haixiao Cheng, Xinran Gao, Xiaoyan Feng, Ming Xue, Yang Liu, Yumin Luo, Zhongbing Lu, Yuming Zhao,
2024, 14(5):2097-2118. DOI:10.1016/j.apsb.2024.02.001
Abstract
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma
Li Peng, Yanyi Jiang, Hengxing Chen, Yongqiang Wang, Qiusheng Lan, Shuiqin Chen, Zhanwang Huang, Jingyuan Zhang, Duanqing Tian, Yuntan Qiu, Diankui Cai, Jiangyun Peng, Daning Lu, Xiaoqing Yuan, Xianzhu Yang, Dong Yin,
2024, 14(5):2119-2136. DOI:10.1016/j.apsb.2024.02.025
Abstract
Small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery
Tarik Zahr, Vijay K. Boda, Jian Ge, Lexiang Yu, Zhongzhi Wu, Jianwen Que, Wei Li, Li Qiang,
2024, 14(5):2137-2152. DOI:10.1016/j.apsb.2024.01.014
Abstract
5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner
Qing Meng, Jianshuang Guo, Ke Lv, Yang Liu, Jin Zhang, Mingyue Li, Xirui Cheng, Shenghua Chen, Xiaoguang Huo, Quan Zhang, Yue Chen, Jing Li,
2024, 14(5):2153-2176. DOI:10.1016/j.apsb.2024.02.020
Abstract
First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway
Peipei Shan, Tao Ye, Ying-De Tang, Hui Song, Chao Wang, Kongkai Zhu, Feifei Yang, Shi-Lei Zhang, Pei-Wen Su, Shuanhu Gao, Hua Zhang,
2024, 14(5):2177-2193. DOI:10.1016/j.apsb.2024.02.012
Abstract
Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy
Zhilin Li, Qianfeng Zhang, Zhiqian Li, Long Ren, Dayi Pan, Qiyong Gong, Zhongwei Gu, Hao Cai, Kui Luo,
2024, 14(5):2194-2209. DOI:10.1016/j.apsb.2024.02.006
Abstract
Rhizoma Drynariae-derived nanovesicles reverse osteoporosis by potentiating osteogenic differentiation of human bone marrow mesenchymal stem cells via targeting ERα signaling
Qing Zhao, Junjie Feng, Fubin Liu, Qianxin Liang, Manlin Xie, Jiaming Dong, Yanfang Zou, Jiali Ye, Guilong Liu, Yue Cao, Zhaodi Guo, Hongzhi Qiao, Lei Zheng, Kewei Zhao,
2024, 14(5):2210-2227. DOI:10.1016/j.apsb.2024.02.005
Abstract
A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment
Jiangtao Fu, Pingping Zhang, Zhiguo Sun, Guodong Lu, Qi Cao, Yiting Chen, Wenbin Wu, Jiabao Zhang, Chunlin Zhuang, Chunquan Sheng, Jiajun Xu, Ying Lu, Pei Wang,
2024, 14(5):2228-2246. DOI:10.1016/j.apsb.2024.02.017
Abstract
Radiation-based immunogenic vaccine combined with a macrophage “checkpoint inhibitor” for boosting innate and adaptive immunity against metastatic colon cancers
Hongbo Xu, Xianya Qin, Yuanyuan Guo, Siyu Zhao, Xingxing Feng, Runzan Zhang, Tianyi Tian, Li Kong, Conglian Yang, Zhiping Zhang,
2024, 14(5):2247-2262. DOI:10.1016/j.apsb.2024.02.015
Abstract
A pH/ROS dual-responsive system for effective chemoimmunotherapy against melanoma via remodeling tumor immune microenvironment
Leilei Wang, Shanshan He, Rong Liu, Yuan Xue, Yuan Quan, Rongying Shi, Xueying Yang, Qing Lin, Xun Sun, Zhirong Zhang, Ling Zhang,
2024, 14(5):2263-2280. DOI:10.1016/j.apsb.2023.12.001
Abstract
Inhalable metal-organic framework-mediated cuproptosis combined with PD-L1 checkpoint blockade for lung metastasis synergistic immunotherapy
Chongzheng Yan, Ying Liu, Guozhi Zhao, Huatian Yang, Huaiyou Lv, Genju Li, Yuhan Li, Yaqing Fu, Fengqin Sun, Yafei Feng, Yizhe Li, Zhongxi Zhao,
2024, 14(5):2281-2297. DOI:10.1016/j.apsb.2024.01.017
Abstract
Metal natural product complex Ru-procyanidins with quadruple enzymatic activity combat infections from drug-resistant bacteria
Jie Shan, Xu Jin, Cong Zhang, Muchen Huang, Jianghao Xing, Qingrong Li, Yuyu Cui, Qiang Niu, Xu Lin Chen, Xianwen Wang,
2024, 14(5):2298-2316. DOI:10.1016/j.apsb.2023.12.017
Abstract
In situ autophagy regulation in synergy with phototherapy for breast cancer treatment
Huijuan Zhang, Xiangyang Xuan, Yaping Wang, Zijun Qi, Kexuan Cao, Yingmei Tian, Chaoqun Wang, Junbiao Chang, Zhenzhong Zhang, Lin Hou,
2024, 14(5):2317-2332. DOI:10.1016/j.apsb.2023.11.019
Abstract
Molecular characterization and structure basis of a malonyltransferase with both substrate promiscuity and catalytic regiospecificity from Cistanche tubulosa
Xiao Liu, Yuyu Liu, Xiping Xu, Wenqian Huang, Yaru Yan, Yingxia Wang, Weisheng Tian, Ting Mo, Xiaoxue Cui, Jun Li, She-Po Shi, Pengfei Tu,
2024, 14(5):2333-2348. DOI:10.1016/j.apsb.2024.02.007
Abstract
Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics
Rabea Voget, Julian Breidenbach, Tobias Claff, Alexandra Hingst, Katharina Sylvester, Christian Steinebach, Lan Phuong Vu, Renato H. Weiße, Ulrike Bartz, Norbert Sträter, Christa E. Müller, Michael Gütschow,
2024, 14(5):2349-2357. DOI:10.1016/j.apsb.2024.03.001
Abstract
Author correction to ‘Pharmacologically targeting molecular motor promotes mitochondrial fission for anti-cancer' [Acta Pharm Sin B 11 (2021) 1853-1866]
Yi Qian, Meimei Zhao, Qinghua Han, Jingkang Wang, Lixi Liao, Heng Yang, Dan Liu, Pengfei Tu, Hong Liang, Kewu Zeng,
2024, 14(5):2358-2358. DOI:10.1016/j.apsb.2024.02.013
Abstract
Author correction to ‘Co-delivery of nigericin and decitabine using hexahistidine-metal nanocarriers for pyroptosis-induced immunotherapeutics' [Acta Pharm Sin B 12 (2022) 4458-4471]
Qiang Niu, Yu Liu, Yujing Zheng, Ziwei Tang, Yuna Qian, Ruogu Qi, Jianliang Shen, Ping Zhao,
2024, 14(5):2359-2360. DOI:10.1016/j.apsb.2024.02.021
Abstract