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Monoclonal antibodies and aptamers: The future therapeutics for Alzheimer's disease
Alvaro Barrera-Ocampo,
2024, 14(7):2795-2814. DOI:10.1016/j.apsb.2024.03.034
Abstract
Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer
Xin Jin, Wenke Jin, Linlin Tong, Jia Zhao, Lan Zhang, Na Lin,
2024, 14(7):2815-2853. DOI:10.1016/j.apsb.2024.04.020
Abstract
Single-domain antibodies as therapeutics for solid tumor treatment
Mingkai Wang, Tianlei Ying, Yanling Wu,
2024, 14(7):2854-2868. DOI:10.1016/j.apsb.2024.03.016
Abstract
The emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health
Weixin Xie, Antonia Donat, Shan Jiang, Anke Baranowsky, Johannes Keller,
2024, 14(7):2869-2884. DOI:10.1016/j.apsb.2024.03.033
Abstract
Lipid-nanoparticle-enabled nucleic acid therapeutics for liver disorders
Porkizhi Arjunan, Durga Kathirvelu, Gokulnath Mahalingam, Ashish Kumar Goel, Uday George Zacharaiah, Alok Srivastava, Srujan Marepally,
2024, 14(7):2885-2900. DOI:10.1016/j.apsb.2024.04.015
Abstract
Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy
Xiaoman Mao, Shuang Wu, Dandan Huang, Chong Li,
2024, 14(7):2901-2926. DOI:10.1016/j.apsb.2024.03.006
Abstract
In silico off-target profiling for enhanced drug safety assessment
Jin Liu, Yike Gui, Jingxin Rao, Jingjing Sun, Gang Wang, Qun Ren, Ning Qu, Buying Niu, Zhiyi Chen, Xia Sheng, Yitian Wang, Mingyue Zheng, Xutong Li,
2024, 14(7):2927-2941. DOI:10.1016/j.apsb.2024.03.002
Abstract
LncRNA ZFPM2-AS1 promotes phyllodes tumor progression by binding to CDC42 and inhibiting STAT1 activation
Shishi He, Guowei Huang, Rong Lei, Rurong Jia, Zhanghai He, Jiewen Chen, Hongyan Huang, Zixian Huang, Ailifeire Yilihamu, Xun Li, Zilin Zhuang, Mengjia Han, Xueman Chen, Di Huang, Yan Nie,
2024, 14(7):2942-2958. DOI:10.1016/j.apsb.2024.04.023
Abstract
KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2
Chaofan Peng, Peng Yang, Dongsheng Zhang, Chi Jin, Wen Peng, Tuo Wang, Qingyang Sun, Zhihao Chen, Yifei Feng, Yueming Sun,
2024, 14(7):2959-2976. DOI:10.1016/j.apsb.2024.04.024
Abstract
Disruption of cyclin D1 degradation leads to the development of mantle cell lymphoma
Ke Lu, Ming Zhang, Hongyu Qin, Siyu Shen, Haiqing Song, Hua Jiang, Chunxiang Zhang, Guozhi Xiao, Liping Tong, Qing Jiang, Di Chen,
2024, 14(7):2977-2991. DOI:10.1016/j.apsb.2024.03.013
Abstract
Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway
Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi,
2024, 14(7):2992-3008. DOI:10.1016/j.apsb.2024.03.030
Abstract
Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors
Saini Setua, Shabia Shabir, Poornima Shaji, Ana Martinez Bulnes, Anupam Dhasmana, Swathi Holla, Nivesh K. Mittal, Nirakar Sahoo, Tripti Saini, Francesco Giorgianni, Mohammad Sikander, Andrew E. Massey, Bilal B. Hafeez, Manish K. Tripathi, Vincent P. Diego, Meena Jaggi, Junming Yue, Nadeem Zafar, Murali M. Yallapu, Stephen W. Behrman, Sheema Khan, Subhash C. Chauhan,
2024, 14(7):3009-3026. DOI:10.1016/j.apsb.2024.04.003
Abstract
ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT
Mengdie Dong, Yunjia Zhang, Minghong Chen, Yongkang Tan, Jiao Min, Xian He, Fuhao Liu, Jiaming Gu, Hong Jiang, Longbin Zheng, Jiajing Chen, Quanwen Yin, Xuesong Li, Xiang Chen, Yongfeng Shao, Yong Ji, Hongshan Chen,
2024, 14(7):3027-3048. DOI:10.1016/j.apsb.2024.03.008
Abstract
PIM1-HDAC2 axis modulates intestinal homeostasis through epigenetic modification
Jianming Yang, Yawen Xiao, Ningning Zhao, Geng Pei, Yan Sun, Xinyu Sun, Kaiyuan Yu, Chunhui Miao, Ran Liu, Junqiang Lv, Hongyu Chu, Lu Zhou, Bangmao Wang, Zhi Yao, Quan Wang,
2024, 14(7):3049-3067. DOI:10.1016/j.apsb.2024.04.017
Abstract
Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice
Dongping Li, Rongjuan Wei, Xianglong Zhang, Shenhai Gong, Meijuan Wan, Fangzhao Wang, Jiaxin Li, Meiling Chen, Ruofan Liu, Yantong Wan, Yinghao Hong, Zhenhua Zeng, Peng Gu, Zhang Wang, Kutty Selva Nandakumar, Yong Jiang, Hongwei Zhou, Peng Chen,
2024, 14(7):3068-3085. DOI:10.1016/j.apsb.2024.03.025
Abstract
Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties
Yihang Hao, Haofan Wang, Xianggen Liu, Wenrui Gai, Shilong Hu, Wencheng Liu, Zhuang Miao, Yu Gan, Xianghua Yu, Rongjia Shi, Yongzhen Tan, Ting Kang, Ao Hai, Yi Zhao, Yihang Fu, Yaling Tang, Ling Ye, Jin Liu, Xinhua Liang, Bowen Ke,
2024, 14(7):3086-3109. DOI:10.1016/j.apsb.2024.01.019
Abstract
Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
Yanying Sun, Zhenzhen Zhou, Zhongling Shi, Fabao Zhao, Minghui Xie, Zongji Zhuo, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu,
2024, 14(7):3110-3124. DOI:10.1016/j.apsb.2024.03.021
Abstract
Glycnsisitin A: A promising bicyclic peptide against heart failure that facilitates TFRC-mediated uptake of iron in cardiomyocytes
Jichao Zhou, Yuanyuan Liu, Xiaoli Wei, Meng Yuan, Xu Zhang, Lingfeng Qin, Bing Cui, Pingping Li, Jing Zhang, Ziming Feng, Jianshuang Jiang, Xiang Yuan, Ruibing Xu, Zhimeng Zhang, Peicheng Zhang, Xiaowei Zhang, Yanan Yang,
2024, 14(7):3125-3139. DOI:10.1016/j.apsb.2024.02.026
Abstract
Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect
Ning Sheng, Rui Li, Yang Li, Zhe Wang, Lulu Wang, Yuhuan Li, Jinlan Zhang, Jiandong Jiang,
2024, 14(7):3140-3154. DOI:10.1016/j.apsb.2024.03.032
Abstract
Julolidinyl aza-BODIPYs as NIR-II fluorophores for the bioimaging of nanocarriers
Chang Liu, Yifan Cai, Zichen Zhang, Yi Lu, Quangang Zhu, Haisheng He, Zhongjian Chen, Weili Zhao, Wei Wu,
2024, 14(7):3155-3168. DOI:10.1016/j.apsb.2024.04.002
Abstract
M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy
Ha Eun Shin, Jun-Hyeok Han, Seungyong Shin, Ga-Hyun Bae, Boram Son, Tae-Hyung Kim, Hee Ho Park, Chun Gwon Park, Wooram Park,
2024, 14(7):3169-3183. DOI:10.1016/j.apsb.2024.03.004
Abstract
An antibiotic-free platform for eliminating persistent Helicobacter pylori infection without disrupting gut microbiota
Yongkang Lai, Tinglin Zhang, Xiaojing Yin, Chunping Zhu, Yiqi Du, Zhaoshen Li, Jie Gao,
2024, 14(7):3184-3204. DOI:10.1016/j.apsb.2024.03.014
Abstract
Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy
Bing-Chen Zhang, Chun-Mei Lai, Bang-Yue Luo, Jing-Wei Shao,
2024, 14(7):3205-3217. DOI:10.1016/j.apsb.2024.04.033
Abstract
Enhancing immunotherapy efficacy against MHC-I deficient triple-negative breast cancer using LCL161-loaded macrophage membrane-decorated nanoparticles
Wen Zhang, Yihui Zhai, Ying Cai, Xiang Gong, Yunxuan Jiang, Rong Rong, Chao Zheng, Binyu Zhu, Helen He Zhu, Hao Wang, Yaping Li, Pengcheng Zhang,
2024, 14(7):3218-3231. DOI:10.1016/j.apsb.2024.04.009
Abstract
A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization
Ping Yu, Tanwei Gu, Yueyang Rao, Weimin Liang, Xi Zhang, Huanguo Jiang, Jindi Lu, Jianglian She, Jianmin Guo, Wei Yang, Yonghong Liu, Yingfeng Tu, Lan Tang, Xuefeng Zhou,
2024, 14(7):3232-3250. DOI:10.1016/j.apsb.2024.03.005
Abstract
Sequential dual-locking strategy using photoactivated Pt(IV)-based metallo-nano prodrug for enhanced chemotherapy and photodynamic efficacy by triggering ferroptosis and macrophage polarization
Jun Li, Qiang Zhang, Hao Yang, Wenli Lu, Yulong Fu, Yingcai Xiong, Xuan Wang, Tianming Lu, Yanlin Xin, Zejuan Xie, Weichao Chen, Guoqiang Wang, Yuanyuan Guo, Ruogu Qi,
2024, 14(7):3251-3265. DOI:10.1016/j.apsb.2024.02.024
Abstract
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
Wenfeng Li, Shuming Chen, Jing Lang, Jing Luo, Jiahui Chen, Liping Zhang, Zhijie Sun, Deli Dong,
2024, 14(7):3266-3280. DOI:10.1016/j.apsb.2024.03.031
Abstract
Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export, SZJK-0421, in multiple myeloma
Jing Wang, Hang Miao, Xuxing Shen, Lin Yang, Yongqiang Zhu, Lijuan Chen,
2024, 14(7):3281-3285. DOI:10.1016/j.apsb.2024.04.014
Abstract
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
Miao Zheng, Bo Feng, Yumin Zhang, Xin Liu, Na Zhao, Hui Liu, Zichao Xu, Xinheng He, Zhiyan Qu, Shizhao Chen, Zhidong Jiang, Xi Cheng, Hong Liu, Yi Zang, Linxiang Zhao, Jie Zheng, Leike Zhang, Jia Li, Yu Zhou,
2024, 14(7):3286-3290. DOI:10.1016/j.apsb.2024.04.011
Abstract
Commentary: The central lymphatic drainage in pharmacological, surgical and physical therapies of Alzheimer's disease
Lixuan Ren, Jianping Ye,
2024, 14(7):3291-3293. DOI:10.1016/j.apsb.2024.04.018
Abstract
Author correction to “Identification of the dietary supplement capsaicin as an inhibitor of Lassa virus entry” [Acta Pharmaceutica Sinica B 10 (2020) 789-798]
Ke Tang, Xiaoyu Zhang, Ying Guo,
2024, 14(7):3294-3294. DOI:10.1016/j.apsb.2024.04.012
Abstract