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Therapeutic potential of targeting protein tyrosine phosphatases in liver diseases
Ao Wang, Yi Zhang, Xinting Lv, Guang Liang,
2024, 14(8):3295-3311. DOI:10.1016/j.apsb.2024.05.006
Abstract
Progranulin: A promising biomarker and therapeutic target for fibrotic diseases
Fan Yang, Ming-Han Cheng, Hai-Feng Pan, Jian Gao,
2024, 14(8):3312-3326. DOI:10.1016/j.apsb.2024.04.026
Abstract
Mitophagy and cGAS—STING crosstalk in neuroinflammation
Xiaogang Zhou, Jing Wang, Lu Yu, Gan Qiao, Dalian Qin, Betty Yuen-Kwan Law, Fang Ren, Jianming Wu, Anguo Wu,
2024, 14(8):3327-3361. DOI:10.1016/j.apsb.2024.05.012
Abstract
Encoding and display technologies for combinatorial libraries in drug discovery: The coming of age from biology to therapy
Yu Fan, Ruibing Feng, Xinya Zhang, Zhen-Liang Wang, Feng Xiong, Shuihua Zhang, Zhang-Feng Zhong, Hua Yu, Qing-Wen Zhang, Zhang Zhang, Yitao Wang, Guodong Li,
2024, 14(8):3362-3384. DOI:10.1016/j.apsb.2024.04.006
Abstract
The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications
Zichen Luo, Wei Zhou, Tong Xie, Weichen Xu, Chen Shi, Zihan Xiao, Yu Si, Yan Ma, Qingling Ren, Liuqing Di, Jinjun Shan,
2024, 14(8):3385-3415. DOI:10.1016/j.apsb.2024.04.027
Abstract
Unlocking T cell exhaustion: Insights and implications for CAR-T cell therapy
Dian Xiong, Haijun Yu, Zhi-Jun Sun,
2024, 14(8):3416-3431. DOI:10.1016/j.apsb.2024.04.022
Abstract
Engineered nanoparticles for precise targeted drug delivery and enhanced therapeutic efficacy in cancer immunotherapy
Xueqiang Peng, Jianjun Fang, Chuyuan Lou, Liang Yang, Shaobo Shan, Zixian Wang, Yutong Chen, Hangyu Li, Xuexin Li,
2024, 14(8):3432-3456. DOI:10.1016/j.apsb.2024.05.010
Abstract
Advancements in precision nanomedicine design targeting the anoikis-platelet interface of circulating tumor cells
Manqing Tang, Zhijie Zhang, Ping Wang, Feng Zhao, Lin Miao, Yuming Wang, Yingpeng Li, Yunfei Li, Zhonggao Gao,
2024, 14(8):3457-3475. DOI:10.1016/j.apsb.2024.04.034
Abstract
Screening antimicrobial peptides and probiotics using multiple deep learning and directed evolution strategies
Yu Zhang, Li-Hua Liu, Bo Xu, Zhiqian Zhang, Min Yang, Yiyang He, Jingjing Chen, Yang Zhang, Yucheng Hu, Xipeng Chen, Zitong Sun, Qijun Ge, Song Wu, Wei Lei, Kaizheng Li, Hua Cui, Gangzhu Yang, Xuemei Zhao, Man Wang, Jiaqi Xia, Zhen Cao, Ao Jiang, Yi-Rui Wu,
2024, 14(8):3476-3492. DOI:10.1016/j.apsb.2024.05.003
Abstract
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
Longhao Cheng, Xiaoxue Wang, Aijun Liu, Ying Zhu, Hu Cheng, Jiangling Yu, Lili Gong, Honglin Liu, Guolin Shen, Lihong Liu,
2024, 14(8):3493-3512. DOI:10.1016/j.apsb.2024.04.021
Abstract
Suppressing FXR promotes antiviral effects of bile acids via enhancing the interferon transcription
Xue Liang, Kunpeng Liu, Xin Jia, Cuiqin Cheng, Meiqi Zhang, Lingdong Kong, Qiqi Li, Zhe Liu, Min Li, Junliang Li, Yao Wang, Anlong Xu,
2024, 14(8):3513-3527. DOI:10.1016/j.apsb.2024.05.005
Abstract
Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-122-5p, conferring a therapeutic effect on osteoarthritis via the p38/MMP13 pathway
Xiang Li, Ya Zhou, Xuefeng Chen, Hongjun Wang, Shuang Yang, Jun Yang, Yunfeng Song, Zhehui Zhao, Haijing Zhang, Lianqiu Wu,
2024, 14(8):3528-3542. DOI:10.1016/j.apsb.2024.05.016
Abstract
Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation
Lixin Zhao, Yuguang Zhu, Hua Tao, Xiying Chen, Feng Yin, Yingyi Zhang, Jianfeng Qin, Yongyin Huang, Bikun Cai, Yonghao Lin, Jiaxiang Wu, Yu Zhang, Lu Liang, Ao Shen, Xi-Yong Yu,
2024, 14(8):3543-3560. DOI:10.1016/j.apsb.2024.04.013
Abstract
Small molecule α-methylene-γ-butyrolactone, an evolutionarily conserved moiety in sesquiterpene lactones, ameliorates arthritic phenotype via interference DNA binding activity of NF-κB
Kegang Linghu, Wenqing Cui, Taiqin Li, Yueting Tuo, Dasong Wang, Huiqi Pan, Tian Zhang, Ligen Lin, Hua Yu, Xiaoxia Hu, Haiyang Li, Xiangchun Shen,
2024, 14(8):3561-3575. DOI:10.1016/j.apsb.2024.04.004
Abstract
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
Tian Tao, Qing Shu, Yawen Zhao, Wenying Guo, Jinting Wang, Yuhao Shi, Shiqi Jia, Hening Zhai, Hui Chen, Cunchuan Wang, Geyang Xu,
2024, 14(8):3576-3590. DOI:10.1016/j.apsb.2024.04.016
Abstract
Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis
Juan Rong, Chenxia Han, Yan Huang, Yiqin Wang, Qi Qiu, Manjiangcuo Wang, Shisheng Wang, Rui Wang, Juqin Yang, Xia Li, Chenggong Hu, Zhiyao Chen, Lihui Deng, Wei Huang, Qing Xia, Dan Du,
2024, 14(8):3591-3604. DOI:10.1016/j.apsb.2024.04.019
Abstract
Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer
Zehui Tan, Ning Guo, Zhi Cao, Shuyu Liu, Jiayu Zhang, Deyi Ma, Jiahao Zhang, Wencai Lv, Nan Jiang, Linghe Zang, Lihui Wang, Xin Zhai,
2024, 14(8):3605-3623. DOI:10.1016/j.apsb.2024.03.018
Abstract
Discovery of TK-642 as a highly potent, selective, orally bioavailable pyrazolopyrazine-based allosteric SHP2 inhibitor
Kai Tang, Shu Wang, Siqi Feng, Xinyu Yang, Yueyang Guo, Xiangli Ren, Linyue Bai, Bin Yu, Hong-Min Liu, Yihui Song,
2024, 14(8):3624-3642. DOI:10.1016/j.apsb.2024.03.028
Abstract
Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy
Jie Wang, Zilong Zhang, Yan Zhuo, Zhuan Zhang, Rongrong Chen, Li Liang, Xiaohe Jiang, Di Nie, Chang Liu, Zhiwen Zou, Xiang Li, Jiaxin Li, Bingqi Wang, Rui Wang, Yong Gan, Miaorong Yu,
2024, 14(8):3643-3660. DOI:10.1016/j.apsb.2024.04.010
Abstract
Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis
Baolong Liu, Phuong Linh Nguyen, Han Yu, Xingzhi Li, Huiren Wang, Tram Gia Bao Nguyen, Prakash Kumar Sahoo, Meghna Sur, Jay Reddy, Sarah Sillman, Stephen D. Kachman, Bara Altartouri, Guoqing Lu, Sathish Kumar Natarajan, Mahesh Pattabiraman, Jiujiu Yu,
2024, 14(8):3661-3679. DOI:10.1016/j.apsb.2024.05.002
Abstract
Dendritic nanomedicine enhances chemo-immunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells
Yunkun Li, Xiaoding Shen, Haitao Ding, Yuxin Zhang, Dayi Pan, Liping Su, Yahui Wu, Zaixiang Fang, Jie Zhou, Qiyong Gong, Kui Luo,
2024, 14(8):3680-3696. DOI:10.1016/j.apsb.2024.03.010
Abstract
Inhalable nanoparticles with enhanced cuproptosis and cGAS—STING activation for synergistic lung metastasis immunotherapy
Chongzheng Yan, Huaiyou Lv, Yafei Feng, Yuhan Li, Zhongxi Zhao,
2024, 14(8):3697-3710. DOI:10.1016/j.apsb.2024.04.028
Abstract
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β
Boning Niu, Tianyi Tian, Lu Wang, Yinmei Tian, Tian Tian, Yuanyuan Guo, Hu Zhou, Zhiping Zhang,
2024, 14(8):3711-3729. DOI:10.1016/j.apsb.2024.05.009
Abstract
Remote-controlled dexamethasone-duration on eye-surface with a micelle-magnetic nanoparticulate co-delivery system for dry eye disease
Qinxiang Zheng, Chaoxiang Ge, Kexin Li, Longxin Wang, Xiaoyu Xia, Xiao Liu, Rashid Mehmood, Jianliang Shen, Kaihui Nan, Wei Chen, Sen Lin,
2024, 14(8):3730-3745. DOI:10.1016/j.apsb.2024.05.004
Abstract
Functional characterization, structural basis, and protein engineering of a rare flavonoid 2′-O-glycosyltransferase from Scutellaria baicalensis
Zilong Wang, Xueqing Du, Guo Ye, Haotian Wang, Yizhan Liu, Chenrui Liu, Fudong Li, Hans Ågren, Yang Zhou, Junhao Li, Chao He, De-An Guo, Min Ye,
2024, 14(8):3746-3759. DOI:10.1016/j.apsb.2024.04.001
Abstract
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
Qien Li, Yiqun Dai, Xin-Cheng Huang, Lanlan Sun, Kaixuan Wang, Xiao Guo, Dingqiao Xu, Digao Wan, Latai An, Zixuan Wang, Huanying Tang, Qi Qi, Huihui Zeng, Minjian Qin, Jia-Yu Xue, Yucheng Zhao,
2024, 14(8):3760-3773. DOI:10.1016/j.apsb.2024.04.005
Abstract
Lyophilized lymph nodes: A paradigm shift in CAR T-cell delivery for solid tumor therapy
Qiuhua Luo, Xiaojing Yan, Hong-Xu Liu, Heran Li,
2024, 14(8):3774-3776. DOI:10.1016/j.apsb.2024.05.023
Abstract
DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment
Miao Mao, Zhe Pu, Yuanqing Zhang,
2024, 14(8):3777-3779. DOI:10.1016/j.apsb.2024.05.020
Abstract
SOX17-mediated immune evasion in early colorectal cancer: From pre-malignant adaptation to tumor progression
Yanfeng Gao, Yanping Wang, Jinsong Zhao, Yujun Song,
2024, 14(8):3780-3782. DOI:10.1016/j.apsb.2024.05.021
Abstract
Author correction to ‘3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma’ [Acta Pharm Sin B 10 (2020) 301—312]
Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang, Tengfei Ji, Guanhua Du,
2024, 14(8):3783-3784. DOI:10.1016/j.apsb.2024.04.025
Abstract