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The applications and advances of artificial intelligence in drug regulation: A global perspective
Lixia Fu, Guoshu Jia, Zhenming Liu, Xiaocong Pang, Yimin Cui,
2025, 15(1):1-14. DOI:10.1016/j.apsb.2024.11.006
Abstract
Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications
Umesh Chandra Dash, Nitish Kumar Bhol, Sandeep Kumar Swain, Rashmi Rekha Samal, Prabhat Kumar Nayak, Vishakha Raina, Sandeep Kumar Panda, Rout George Kerry, Asim K. Duttaroy, Atala Bihari Jena,
2025, 15(1):15-34. DOI:10.1016/j.apsb.2024.10.004
Abstract
Drug discovery targeting thyroid hormone receptor β (THRβ) for the treatment of liver diseases and other medical indications
Kean Wang, Feiyang Chen, Jiang Wang, Hong Liu,
2025, 15(1):35-51. DOI:10.1016/j.apsb.2024.07.025
Abstract
Advances and prospects of RNA delivery nanoplatforms for cancer therapy
Mohamed S. Attia, Gregor Kijanka, Nam-Trung Nguyen, Jun Zhang, Hongjie An,
2025, 15(1):52-96. DOI:10.1016/j.apsb.2024.09.009
Abstract
Recent advances in the bench-to-bedside translation of cancer nanomedicines
Yang Liu, Yinchao Zhang, Huikai Li, Tony Y. Hu,
2025, 15(1):97-122. DOI:10.1016/j.apsb.2024.12.007
Abstract
Real-world efficacy and safety of azvudine in hospitalized older patients with COVID-19 during the omicron wave in China: A retrospective cohort study
Yuanchao Zhu, Fei Zhao, Yubing Zhu, Xingang Li, Deshi Dong, Bolin Zhu, Jianchun Li, Xin Hu, Zinan Zhao, Wenfeng Xu, Yang Jv, Dandan Wang, Yingming Zheng, Yiwen Dong, Lu Li, Shilei Yang, Zhiyuan Teng, Ling Lu, Jingwei Zhu, Linzhe Du, Yunxin Liu, Lechuan Jia, Qiujv Zhang, Hui Ma, Ana Zhao, Hongliu Jiang, Xin Xu, Jinli Wang, Xuping Qian, Wei Zhang, Tingting Zheng, Chunxia Yang, Xuguang Chen, Kun Liu, Huanhuan Jiang, Dongxiang Qu, Jia Song, Hua Cheng, Wenfang Sun, Hanqiu Zhan, Xiao Li, Yafeng Wang, Aixia Wang, Li Liu, Lihua Yang, Nan Zhang, Shumin Chen, Jingjing Ma, Wei Liu, Xiaoxiang Du, Meiqin Zheng, Liyan Wan, Guangqing Du, Hangmei Liu, Pengfei Jin,
2025, 15(1):123-132. DOI:10.1016/j.apsb.2024.12.004
Abstract
GSFM: A genome-scale functional module transformation to represent drug efficacy for in silico drug discovery
Saisai Tian, Xuyang Liao, Wen Cao, Xinyi Wu, Zexi Chen, Jinyuan Lu, Qun Wang, Jinbo Zhang, Luonan Chen, Weidong Zhang,
2025, 15(1):133-150. DOI:10.1016/j.apsb.2024.08.017
Abstract
Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease
Aoxiang Zhuge, Shengjie Li, Shengyi Han, Yin Yuan, Jian Shen, Wenrui Wu, Kaicen Wang, Jiafeng Xia, Qiangqiang Wang, Yifeng Gu, Enguo Chen, Lanjuan Li,
2025, 15(1):151-167. DOI:10.1016/j.apsb.2024.10.010
Abstract
Facilitation of mucosal healing by estrogen receptor β in ulcerative colitis through suppression of branched-chain amino acid transport and subsequent triggering of autophagy in colonic epithelial cells
Yilei Guo, Yanrong Zhu, Jing Zhang, Yue He, Mianjiang Zhao, Haochang Lin, Zhifeng Wei, Yufeng Xia, Yue Dai,
2025, 15(1):168-187. DOI:10.1016/j.apsb.2024.11.014
Abstract
Tumor-intrinsic PRMT5 upregulates FGL1 via methylating TCF12 to inhibit CD8+ T-cell-mediated antitumor immunity in liver cancer
Jiao Sun, Hongfeng Yuan, Linlin Sun, Lina Zhao, Yufei Wang, Chunyu Hou, Huihui Zhang, Pan Lv, Guang Yang, Ningning Zhang, Wei Lu, Xiaodong Zhang,
2025, 15(1):188-204. DOI:10.1016/j.apsb.2024.10.016
Abstract
Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation
Wanghui Jing, Sijing Dong, Yinyue Xu, Jingjing Liu, Jiawei Ren, Xue Liu, Min Zhu, Menggai Zhang, Hehe Shi, Na Li, Peng Xia, Haitao Lu, Sicen Wang,
2025, 15(1):205-223. DOI:10.1016/j.apsb.2024.11.009
Abstract
Free fatty acid receptor-4 regulates T-cell-mediated allogeneic reaction through activating an aryl hydrocarbon receptor pathway
Maxwell Duah, Fei Zheng, Jingyi Shen, Yan Xu, Shuo Cao, Zhiling Yan, Qiu Lan, Ying Wang, Kailin Xu, Bin Pan,
2025, 15(1):224-238. DOI:10.1016/j.apsb.2024.12.011
Abstract
Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke
Kangrui Hu, Zhihao Zhou, Haofeng Li, Jijun Xiao, Yun Shen, Ke Ding, Tingting Zhang, Guangji Wang, Haiping Hao, Yan Liang,
2025, 15(1):239-255. DOI:10.1016/j.apsb.2024.10.003
Abstract
Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation
Luxun Tang, Yu Shi, Qiao Liao, Feng Wang, Hao Wu, Hongmei Ren, Xuemei Wang, Wenbin Fu, Jialing Shou, Wei Eric Wang, Pedro A. Jose, Yongjian Yang, Chunyu Zeng,
2025, 15(1):256-277. DOI:10.1016/j.apsb.2024.11.001
Abstract
Dual activation of GCGR/GLP1R signaling ameliorates intestinal fibrosis via metabolic regulation of histone H3K9 lactylation in epithelial cells
Han Liu, Yujie Hong, Hui Chen, Xianggui Wang, Jiale Dong, Xiaoqian Li, Zihan Shi, Qian Zhao, Longyuan Zhou, JiaXin Wang, Qiuling Zeng, Qinglin Tang, Qi Liu, Florian Rieder, Baili Chen, Minhu Chen, Rui Wang, Yao Zhang, Ren Mao, Xianxing Jiang,
2025, 15(1):278-295. DOI:10.1016/j.apsb.2024.11.017
Abstract
N6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis
Sai Zhu, Xin Chen, Lijiao Sun, Xiaofeng Li, Yu Chen, Liangyun Li, Xiaoguo Suo, Chuanhui Xu, Minglu Ji, Jianan Wang, Hua Wang, Lei Zhang, Xiaoming Meng, Cheng Huang, Jun Li,
2025, 15(1):296-313. DOI:10.1016/j.apsb.2024.11.003
Abstract
Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A
Li Zhu, Yi Huang, Jing Jin, Rongjun Zou, Rui Zuo, Yong Luo, Ziqing Song, Linfeng Dai, Minyi Zhang, Qiuhe Chen, Yunting Wang, Wei Wang, Rongrong He, Yang Chen,
2025, 15(1):314-330. DOI:10.1016/j.apsb.2024.11.015
Abstract
YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease
Jinfeng Sun, Fan Chen, Lingyu She, Yuqing Zeng, Hao Tang, Bozhi Ye, Wenhua Zheng, Li Xiong, Liwei Li, Luyao Li, Qin Yu, Linjie Chen, Wei Wang, Guang Liang, Xia Zhao,
2025, 15(1):331-348. DOI:10.1016/j.apsb.2024.11.020
Abstract
The PGAM5-NEK7 interaction is a therapeutic target for NLRP3 inflammasome activation in colitis
Cheng-Long Gao, Jinqian Song, Haojie Wang, Qinghong Shang, Xin Guan, Gang Xu, Jiayang Wu, Dalei Wu, Yueqin Zheng, Xudong Wu, Feng Zhao, Xindong Liu, Lei Shi, Tao Pang,
2025, 15(1):349-370. DOI:10.1016/j.apsb.2024.11.019
Abstract
Drofenine as a Kv2.1 inhibitor alleviated AD-like pathology in mice through Aβ/Kv2.1/microglial NLRP3/neuronal Tau axis
Jian Lu, Qian Zhou, Danyang Zhu, Hongkuan Song, Guojia Xie, Xuejian Zhao, Yujie Huang, Peng Cao, Jiaying Wang, Xu Shen,
2025, 15(1):371-391. DOI:10.1016/j.apsb.2024.11.010
Abstract
Discovery of a novel thiophene carboxamide analogue as a highly potent and selective sphingomyelin synthase 2 inhibitor for dry eye disease therapy
Jintong Yang, Yiteng Lu, Kexin Hu, Xinchen Zhang, Wei Wang, Deyong Ye, Mingguang Mo, Xin Xiao, Xichen Wan, Yuqing Wu, Shuxian Zhang, He Huang, Zhibei Qu, Yimin Hu, Yu Cao, Jiaxu Hong, Lu Zhou,
2025, 15(1):392-408. DOI:10.1016/j.apsb.2024.10.005
Abstract
Dimeric natural product panepocyclinol A inhibits STAT3 via di-covalent modification
Li Li, Yuezhou Wang, Yiqiu Wang, Xiaoyang Li, Qihong Deng, Fei Gao, Wenhua Lian, Yunzhan Li, Fu Gui, Yanling Wei, Su-Jie Zhu, Cai-Hong Yun, Lei Zhang, Zhiyu Hu, Qingyan Xu, Xiaobing Wu, Lanfen Chen, Dawang Zhou, Jianming Zhang, Fei Xia, Xianming Deng,
2025, 15(1):409-423. DOI:10.1016/j.apsb.2024.10.001
Abstract
Cyclometalated iridium(III) complex based on isoquinoline alkaloid synergistically elicits the ICD response and IDO inhibition via autophagy-dependent ferroptosis
Yuan Lu, Shan-Shan Wang, Meng-Ya Li, Rong Liu, Meng-Fan Zhu, Liang-Mei Yang, Feng-Yang Wang, Ke-Bin Huang, Hong Liang,
2025, 15(1):424-437. DOI:10.1016/j.apsb.2024.06.017
Abstract
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
Yang Li, Yan Fang, Xiaoyu Chen, Linjiang Tong, Fang Feng, Qianqian Zhou, Shulun Chen, Jian Ding, Hua Xie, Ao Zhang,
2025, 15(1):438-466. DOI:10.1016/j.apsb.2024.10.002
Abstract
Natural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA
Tianyang Chen, Guangju Liu, Sisi Chen, Fengyuan Zhang, Shuoqian Ma, Yongping Bai, Quan Zhang, Yahui Ding,
2025, 15(1):467-483. DOI:10.1016/j.apsb.2024.07.013
Abstract
Real-time platelet P2Y12 receptor occupancy as a promising pharmacodynamics biomarker for bridging the gap between PK/PD of clopidogrel therapy
Haipeng Li, Yueming Gu, Yumeng Zhao, Aiyun Xu, Dong Sun, Jingkai Gu,
2025, 15(1):484-493. DOI:10.1016/j.apsb.2024.08.008
Abstract
“Relative symmetry with electronegativity of different key-groups” strategy for MRGPRX2 antagonist design and its effect on antigen-induced pulmonary inflammation
Jiayu Lu, Zhaomin Xia, Yongjing Zhang, He Wang, Wen Yang, Siqi Wang, Nan Wang, Yun Liu, Huaizhen He, Cheng Wang, Langchong He,
2025, 15(1):494-507. DOI:10.1016/j.apsb.2024.11.023
Abstract
Discovery of a novel AhR-CYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay
Feng Zhang, Bei Zhao, Yufan Fan, Lanhui Qin, Jinhui Shi, Lin Chen, Leizhi Xu, Xudong Jin, Mengru Sun, Hongping Deng, Hairong Zeng, Zhangping Xiao, Xin Yang, Guangbo Ge,
2025, 15(1):508-525. DOI:10.1016/j.apsb.2024.09.014
Abstract
Iron and siRNA co-encapsulated ferritin nanocages induce ferroptosis synergistically for cancer therapy
Danni Liu, Yaoqi Wang, Qi Sun, Dong Mei, Xiaoling Wang, Yan Su, Jie Zhang, Ran Huo, Yang Tian, Siyu Liu, Shuang Zhang, Chunying Cui,
2025, 15(1):526-541. DOI:10.1016/j.apsb.2024.10.006
Abstract
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis
Shaobing Li, Juntao Lin, Chengxinqiao Wang, Junhan Liu, Yupeng Wang, Yan Chen, Dongfang Zhou,
2025, 15(1):542-556. DOI:10.1016/j.apsb.2024.11.007
Abstract
Cocrystal pleomorphism-inspired drug nanoassembly for pulmonary-endothelium targeting and pulmonary hypertension treatment
Makhloufi Zoulikha, Jiahui Zou, Pei Yang, Jun Wu, Wei Wu, Kun Hao, Wei He,
2025, 15(1):557-570. DOI:10.1016/j.apsb.2024.11.008
Abstract
Nanoengineered cargo with targeted in vivo Foxo3 gene editing modulated mitophagy of chondrocytes to alleviate osteoarthritis
Manyu Chen, Yuan Liu, Quanying Liu, Siyan Deng, Yuhan Liu, Jiehao Chen, Yaojia Zhou, Xiaolin Cui, Jie Liang, Xingdong Zhang, Yujiang Fan, Qiguang Wang, Bin Shen,
2025, 15(1):571-591. DOI:10.1016/j.apsb.2024.12.008
Abstract
Caffeic acid-vanadium nanozymes treat skin flap ischemia-reperfusion injury through macrophage reprogramming and the upregulation of X-linked inhibitors of apoptotic proteins
Xinyu Zhao, Jie Shan, Hanying Qian, Xu Jin, Yiwei Sun, Jianghao Xing, Qingrong Li, Xu-Lin Chen, Xianwen Wang,
2025, 15(1):592-610. DOI:10.1016/j.apsb.2024.08.022
Abstract
Unlocking the role of wound microbiome in diabetic, burn, and germ-free wound repair treated by natural and synthetic scaffolds
Zeyu Xu, Lixiang Zhang, Qinghan Tang, Chenxi Yang, Xiaotong Ding, Ziyu Wang, Rizhong Huang, Ruihan Jiang, Joannake Maitz, Huaikai Shi, Xin Yan, Mei Dong, Jun Chen, Yiwei Wang,
2025, 15(1):611-626. DOI:10.1016/j.apsb.2024.08.024
Abstract
In situ tumor cell engineering reverses immune escape to enhance immunotherapy effect
Shujun Liu, Shijun Yuan, Meichen Liu, Jinhu Liu, Shunli Fu, Tong Gao, Shuang Liang, Xinyan Huang, Xinke Zhang, Yongjun Liu, Zipeng Zhang, Na Zhang,
2025, 15(1):627-641. DOI:10.1016/j.apsb.2024.08.028
Abstract
Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy
Kuirong Mao, Huizhu Tan, Xiuxiu Cong, Ji Liu, Yanbao Xin, Jialiang Wang, Meng Guan, Jiaxuan Li, Ge Zhu, Xiandi Meng, Guojiao Lin, Haorui Wang, Jing Han, Ming Wang, Yong-Guang Yang, Tianmeng Sun,
2025, 15(1):642-656. DOI:10.1016/j.apsb.2024.08.030
Abstract
Microglial APOE4 promotes neuron degeneration in Alzheimer's disease through inhibition of lipid droplet autophagy
Meng Mao, Xiwen Ma, Xiaochuan Wang, Jianping Ye,
2025, 15(1):657-660. DOI:10.1016/j.apsb.2024.10.009
Abstract
DiPTAC: A degradation platform via directly targeting proteasome
Yutong Tu, Qian Yu, Mengna Li, Lixin Gao, Jialuo Mao, Jingkun Ma, Xiaowu Dong, Jinxin Che, Chong Zhang, Linghui Zeng, Huajian Zhu, Jiaan Shao, Jingli Hou, Liming Hu, Bingbing Wan, Jia Li, Yubo Zhou, Jiankang Zhang,
2025, 15(1):661-664. DOI:10.1016/j.apsb.2024.09.003
Abstract
Emerging therapeutic strategies: The potential of caffeic acid-vanadium nanozymes in modulating macrophage function and reducing skin flap ischemia-reperfusion injury
Jintao Fu, Huile Gao,
2025, 15(1):665-666. DOI:10.1016/j.apsb.2025.01.012
Abstract
The homotherapy for heteropathy: GCGR/GLP1R pathway in fibrotic diseases
Yang Sun,
2025, 15(1):667-668. DOI:10.1016/j.apsb.2025.01.013
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica