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Self-illuminating liposome-derived in situ triggerable photodynamic therapy combining radionuclide therapy for synergistic treatment of lung cancer
Chunsen Yuan, Taotao Jin, Hangke Lei, Juanjuan Liu, Wendan Pu, Yang Zhang, Chenwen Li, Dingde Huang, Jianxiang Zhang, Jiawei Guo,
2025, 15(10):4973-4994. DOI:10.1016/j.apsb.2025.06.026
Abstract
A dual-targeting peptide-drug conjugate based on CXCR4 and FOLR1 inhibits triple-negative breast cancer
Kun Wang, Cong Wang, Hange Yang, Gong Chen, Ke Wang, Peihong Ji, Xudong Sun, Xuegong Fan, Jie Ma, Zhencun Cui, Xingkai Wang, Hao Tian, Dengfu Wu, Lu Wang, Zhimin Wang, Jiangyan Liu, Juan Yi, Kuan Hu, Hailong Zhang, Rui Wang,
2025, 15(10):4995-5009. DOI:10.1016/j.apsb.2025.06.012
Abstract
Dissecting the effects of 223Radium on the bone microenvironment
Sergio Barrios, Elisa Serafini, Ludovica La Posta, D. Nicole Meyers, Nicholas J. Dunbar, Paul G. Corn, Florent Elefteriou, Catherine G. Ambrose, Stefano Casarin, Antonios G. Mikos, Eleonora Dondossola,
2025, 15(10):5010-5021. DOI:10.1016/j.apsb.2025.07.035
Abstract
A preclinical and first-in-human study of superstable homogeneous radiolipiodol for revolutionizing interventional diagnosis and treatment of hepatocellular carcinoma
Hu Chen, Yongfu Xiong, Minglei Teng, Yesen Li, Deliang Zhang, Yongjun Ren, Zheng Li, Hui Liu, Xiaofei Wen, Zhenjie Li, Yang Zhang, Syed Faheem Askari Rizvi, Rongqiang Zhuang, Jinxiong Huang, Suping Li, Jingsong Mao, Hongwei Cheng, Gang Liu,
2025, 15(10):5022-5035. DOI:10.1016/j.apsb.2025.02.021
Abstract
Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand
Xin Zhou, Jiahui Chen, Jimmy S. Patel, Wenqing Ran, Yinlong Li, Richard S. Van, Mostafa M. H. Ibrahim, Chunyu Zhao, Yabiao Gao, Jian Rong, Ahmad F. Chaudhary, Guocong Li, Junqi Hu, April T. Davenport, James B. Daunais, Yihan Shao, Chongzhao Ran, Thomas L. Collier, Achi Haider, David M. Schuster, Allan I. Levey, Lu Wang, Gabriel Corfas, Steven H. Liang,
2025, 15(10):5036-5049. DOI:10.1016/j.apsb.2025.05.020
Abstract
PROTAC-loaded nanocapsules degrading BRD4 for radio-chemotherapy sensitization in glioblastoma
Yun Guo, Mingzhu Fang, Shilin Zhang, Zheng Zhou, Zonghua Tian, Haoyu You, Yun Chen, Jingyi Zhou, Xiaobao Yang, Yunke Bi, Chen Jiang, Tao Sun,
2025, 15(10):5050-5070. DOI:10.1016/j.apsb.2025.03.018
Abstract
Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery
Wei Liu, Bo Fan, Te Fang, Hongyao Li, Jin Zhang, Bo Liu, Zhiyu Liu,
2025, 15(10):5071-5098. DOI:10.1016/j.apsb.2025.08.010
Abstract
New insights into translational research in Alzheimer's disease guided by artificial intelligence, computational and systems biology
Shulan Jiang, Zixi Tian, Yuchen Yang, Xiang Li, Feiyan Zhou, Jianhua Cheng, Jihui Lyu, Tingting Gao, Ping Zhang, Hongbin Han, Zhiqian Tong,
2025, 15(10):5099-5126. DOI:10.1016/j.apsb.2025.08.015
Abstract
Protein palmitoylation: A potential therapeutic target in cardiovascular diseases
Sijia Zhao, Yanyan Yang, Hong Li, Pin Sun, Xiangqin He, Chao Wang, Jingjing Zhang, Yu Tian, Tao Yu, Zhirong Jiang,
2025, 15(10):5127-5144. DOI:10.1016/j.apsb.2025.07.041
Abstract
The cutting-edge progress of novel biomedicines in ovulatory dysfunction therapy
Xuzhi Liang, Shiyu Zhang, Dahai Li, Hao Liang, Yueping Yao, Xiuhong Xia, Hang Yu, Mingyang Jiang, Ying Yang, Ming Gao, Lin Liao, Jiangtao Fan,
2025, 15(10):5145-5166. DOI:10.1016/j.apsb.2025.08.008
Abstract
Progress and challenges of functionalized bacterial encapsulation: A novel biotechnology for next-generation biotherapeutics
Ying Zhang, Yuwei Wu, Xinyu Zhao, Qinghua Ye, Lulu Cao, Ming Liu, Bao Gao, Qinya Niu, Nuo Chen, Zixuan Duan, Yu Ding, Juan Wang, Moutong Chen, Ying Li, Qingping Wu,
2025, 15(10):5167-5191. DOI:10.1016/j.apsb.2025.07.028
Abstract
A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis
Yuan Jiang, Bowen Zhang, Bo Zhang, Xinhua Song, Xiangyu Wang, Wei Zeng, Liyang Zuo, Xinqi Liu, Zheng Dong, Wenzheng Cheng, Yang Qiao, Saidi Jin, Dongni Ji, Xiaofei Guo, Rong Zhang, Xieyang Gong, Lihua Sun, Lina Xuan, Berezhnova Tatjana Alexandrovna, Xiaoxiang Guan, Mingyu Zhang, Baofeng Yang, Chaoqian Xu,
2025, 15(10):5192-5211. DOI:10.1016/j.apsb.2025.07.036
Abstract
VIRMA-mediated SHQ1 m6A modification enhances liver regeneration through an HNRNPA2B1-dependent mechanism
Hao Chen, Haichuan Wang, Jiwei Huang, Guoteng Qiu, Zheng Zhang, Lin Xu, Xiao Ma, Zhen Wang, Xiangzheng Chen, Yong Zeng,
2025, 15(10):5212-5230. DOI:10.1016/j.apsb.2025.07.025
Abstract
Divergent activation patterns of BRS3 revealed by two Chinese herb-derived agonists
Jie Li, Changyao Li, Qingtong Zhou, Wei Han, Mingzhu Fang, Youwei Xu, Yiting Mai, Yao Zhang, Jiahua Cui, H. Eric Xu, Yan Zhang, Wanchao Yin, Ming-Wei Wang,
2025, 15(10):5231-5243. DOI:10.1016/j.apsb.2025.06.025
Abstract
Bacteroides fragilis-derived succinic acid promotes the degradation of uric acid by inhibiting hepatic AMPD2: Insight into how plant-based berberine ameliorates hyperuricemia
Libin Pan, Ru Feng, Jiachun Hu, Hang Yu, Qian Tong, Xinyu Yang, Jianye Song, Hui Xu, Mengliang Ye, Zhengwei Zhang, Jie Fu, Haojian Zhang, Jinyue Lu, Zhao Zhai, Jingyue Wang, Yi Zhao, Hengtong Zuo, Xiang Hui, Jiandong Jiang, Yan Wang,
2025, 15(10):5244-5260. DOI:10.1016/j.apsb.2025.08.009
Abstract
Cannabidiol alleviates methamphetamine addiction via targeting ATP5A1 and modulating the ATP-ADO-A1R signaling pathway
Sha Jin, Cong Lin, Peipei Li, Xue Wang, Yibo Wang, Cong Zhang, Xuenan Wang, Yinghua Peng, Haohong Li, Yuyuan Lu, Xiaohui Wang,
2025, 15(10):5261-5276. DOI:10.1016/j.apsb.2025.08.011
Abstract
Natural killer cell-derived granzyme B as a therapeutic target for alleviating graft injury during liver transplantation
Kai Wang, Zhoucheng Wang, Xin Shao, Lijun Meng, Chuanjun Liu, Nasha Qiu, Wenwen Ge, Yutong Chen, Xiao Tang, Xiaodong Wang, Zhengxing Lian, Ruhong Zhou, Shusen Zheng, Xiaohui Fan, Xiao Xu,
2025, 15(10):5277-5293. DOI:10.1016/j.apsb.2025.07.042
Abstract
Succinylation of tumor suppressor PPP2R1A K541 by HAT1 converses the role in modulation of gluconeogenesis/lipogenesis remodeling to display oncogene function
Guang Yang, Yufei Wang, Hongfeng Yuan, Huihui Zhang, Lina Zhao, Chunyu Hou, Pan Lv, Jihui Hao, Xiaodong Zhang,
2025, 15(10):5294-5311. DOI:10.1016/j.apsb.2025.07.040
Abstract
Discovery of orally active and serine-targeting covalent inhibitors against hCES2A for ameliorating irinotecan-triggered gut toxicity
Ya Zhang, Yufan Fan, Yunqing Song, Guanghao Zhu, Xinjuan Li, Jian Huang, Xinrui Guo, Changhai Luan, Dongning Kang, Lu Chen, Zhangping Xiao, Zhaobin Guo, Hairong Zeng, Dapeng Chen, Zhipei Sang, Guangbo Ge,
2025, 15(10):5312-5326. DOI:10.1016/j.apsb.2025.08.007
Abstract
Evolution-guided design of mini-protein for high-contrast in vivo imaging
Nongyu Huang, Yang Cao, Guangjun Xiong, Suwen Chen, Juan Cheng, Yifan Zhou, Chengxin Zhang, Xiaoqiong Wei, Wenling Wu, Yawen Hu, Pei Zhou, Guolin Li, Fulei Zhao, Fanlian Zeng, Xiaoyan Wang, Jiadong Yu, Chengcheng Yue, Xinai Cui, Kaijun Cui, Huawei Cai, Yuquan Wei, Yang Zhang, Jiong Li,
2025, 15(10):5327-5345. DOI:10.1016/j.apsb.2025.07.015
Abstract
Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development
Wanyu Tang, Zhixue Ma, Bang Li, Zhexiang Yu, Xiaobao Zhao, Huicui Yang, Jian Hu, Sheng Tian, Linghan Gu, Jiaojiao Chen, Xing Zou, Qi Wang, Fan Chen, Guangying Li, Chaonan Zheng, Shuliu Gao, Wenjing Liu, Yue Li, Wenhua Zheng, Mingmei Wang, Na Ye, Xuechu Zhen,
2025, 15(10):5346-5365. DOI:10.1016/j.apsb.2025.04.028
Abstract
Anti-CD24 antibody-nitric oxide donor conjugates bearing a self-bioorthogonal cleavable linker
Jianbing Wu, Tianyue Cheng, Jiajun Xie, Ziyu Qian, Linhua Huang, Xun Yuan, Libang Zhang, Shan Yang, Yihua Zhang, Tonglin Xu, Juan Zhang, Zhangjian Huang,
2025, 15(10):5366-5386. DOI:10.1016/j.apsb.2025.07.037
Abstract
A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia
Jesse Dangerfield, Aaron DeBono, Andrew N. Keller, Tracy M. Josephs, David M. Shackleford, Karen J. Gregory, Katie Leach, Ben Capuano,
2025, 15(10):5387-5399. DOI:10.1016/j.apsb.2025.07.044
Abstract
Cerium single-atom catalysts-armed Lactobacillus reuteri for multipronged anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease
Yinying Pu, Shaorong Huang, Shuang Gao, Yangying Duan, Wenhao Li, Qiyue Li, Han Lin, Kun Zhang, Min Zhou, Wencheng Wu,
2025, 15(10):5400-5415. DOI:10.1016/j.apsb.2025.06.022
Abstract
Targeted delivery of BMPR2 mRNA attenuates pulmonary arterial hypertension by reversing pulmonary vascular remodeling
Yan Cao, Runyuan Wang, Xiaoyan He, Yan Ding, Yan Chang, Runyue Yang, Guisheng Zhong, Huiying Yang, Jianfeng Li,
2025, 15(10):5416-5430. DOI:10.1016/j.apsb.2025.07.004
Abstract
Spatiotemporally delivery of Cas9 ribonucleoprotein/DNAzyme logic systems using near-infrared upconversion nanomachine for precise immunotherapy
Chao Chen, Shiyu Du, Qianglan Lu, Xueting Shen, Shuai Ding, Lihua Qu, Yamei Gao, Zhiqiang Yin, Zhe Li, Yujun Song, Xin Han,
2025, 15(10):5431-5443. DOI:10.1016/j.apsb.2025.07.010
Abstract
Nucleic acid-based delivery system delivering platinum drugs cooperates with siRNA for potentiated chemo-immunotherapy by reducing phosphatidylserine exposure and activating the cGAS-STING pathway
Jianqin Yan, Zijian Zhao, Dengshuai Wei, Huapeng Zheng, Bin He, Yong Sun,
2025, 15(10):5444-5457. DOI:10.1016/j.apsb.2025.07.027
Abstract
Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells
Changshun Zhao, Wei Wang, Zhengchun Huang, Yuqing Wan, Rui Xu, Junmei Zhang, Bingbing Zhao, Ke Wang, Suchen Wen, Yinan Zhong, Dechun Huang, Wei Chen,
2025, 15(10):5458-5473. DOI:10.1016/j.apsb.2025.08.001
Abstract
mRNA display-enabled discovery of proximity-triggered covalent peptide-drug conjugates
Ruixuan Wang, Siqi Ran, Jiabei Guo, Da Hu, Xiang Feng, Jixia zhou, Zhanzhi Zhang, Futian Liang, Jiamin Shang, Lingxin Bu, Kaiyi Wang, Junyi Mao, Huixin Luo, Rui Wang,
2025, 15(10):5474-5485. DOI:10.1016/j.apsb.2025.07.029
Abstract
A mechanism underlying the association of Aβ plaque and lipid droplets in Alzheimer's disease
Lixuan Ren, Xiwen Ma, Jianping Ye,
2025, 15(10):5486-5488. DOI:10.1016/j.apsb.2025.06.018
Abstract
Discovery of novel radioligand [18F]AZD9574 for selective imaging of PARP1 in the CNS
Xiaoyun Zhou, Kai Chen,
2025, 15(10):5489-5490. DOI:10.1016/j.apsb.2025.09.021
Abstract
Advances in selective targeting of serine hydrolases: A targeted covalent approach against hCES2A mitigates irinotecan toxicity in vivo
Elena De Vita,
2025, 15(10):5491-5492. DOI:10.1016/j.apsb.2025.09.023
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica