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Antisense molecules: A promising new therapy for atopic dermatitis
Jiayi Xue, Zhirong Yao,
2025, 15(11):5493-5514. DOI:10.1016/j.apsb.2025.09.008
Abstract
Intestinal barrier in chronic gut and liver diseases: Pathogenesis and therapeutic targets
Yongxin Zhang, Yameng Liu, Xinyu Liang, Yingquan Wen, Jingjie Zhao, Yong He, Qing Xie, Cen Xie,
2025, 15(11):5515-5536. DOI:10.1016/j.apsb.2025.08.028
Abstract
Targeting pattern recognition receptors for cancer therapy: Mechanisms and strategies
Dengjie Ouyang, Ruixian Chen, Haitong Xie, Xiwen Yang, Qintong Li, Jie Chen,
2025, 15(11):5537-5600. DOI:10.1016/j.apsb.2025.09.007
Abstract
The epigenetic landscape of rheumatoid arthritis: Pathogenesis and drug therapeutic potentials
Chengcheng Huang, Yuxiang Liang, Yang Li, Quan Wei, Liang Ouyang, Jifa Zhang,
2025, 15(11):5601-5631. DOI:10.1016/j.apsb.2025.08.022
Abstract
Next-generation clinically relevant antibody detection: Unlocking electrochemical biosensors for critical disease management
Zheng Zhao, Zhiwei Chen, Jacques Crommen, Shengfeng Huang, Qiqin Wang, Zhengjin Jiang,
2025, 15(11):5632-5662. DOI:10.1016/j.apsb.2025.08.016
Abstract
Engineered plant extracellular vesicles: Emerging nanoplatforms for combinational cancer immunotherapy
Fucai Chen, Rongrong Bao, Wanyi Yang, Yijing Lu, Jiaxin Guo, Wenjing Chen, Jiale Li, Kuanhan Feng, Wen Zhang, Liuqing Di, Liang Feng, Ruoning Wang,
2025, 15(11):5663-5701. DOI:10.1016/j.apsb.2025.08.020
Abstract
Application of artificial intelligence in laboratory hematology: Advances, challenges, and prospects
Hongyan Liao, Feng Zhang, Fengyu Chen, Yifei Li, Yanrui Sun, Darcée D. Sloboda, Qin Zheng, Binwu Ying, Tony Hu,
2025, 15(11):5702-5733. DOI:10.1016/j.apsb.2025.05.036
Abstract
Technologies and applications of current human cardiac organoids
Huan-Yu Zhao, Jie-Bing Jiang, Shu-Na Wang, Chao-Yu Miao,
2025, 15(11):5734-5757. DOI:10.1016/j.apsb.2025.09.013
Abstract
CarsiDock-Cov: A deep learning-guided approach for automated covalent docking and screening
Chao Shen, Hongyan Du, Xujun Zhang, Shukai Gu, Heng Cai, Yu Kang, Peichen Pan, Qingwei Zhao, Tingjun Hou,
2025, 15(11):5758-5771. DOI:10.1016/j.apsb.2025.07.043
Abstract
Brain endothelial HIF-1α exacerbates diabetes-associated cognitive impairment by accelerating glycolysis-driven lactate production
Jicong Chen, Ruohui Lin, Cuihua Jiang, Fang Chen, Wei Li, Lei Wang, Ke Pan, Jian Zhang, Zhiqi Yin, Yaping Huang,
2025, 15(11):5772-5788. DOI:10.1016/j.apsb.2025.09.028
Abstract
Targeting SARS-CoV-2 main protease for the discovery of a broad-spectrum COVID-19 inhibitor by intensive multi-tiered validation
Min Zhang, Changjian Wang, Lu Feng, Qi Yang, Yipeng Cao, Yao Zhao, Junhua Zhang, Yuefei Wang, Zihe Rao, Boli Zhang,
2025, 15(11):5789-5802. DOI:10.1016/j.apsb.2025.09.033
Abstract
CRTAC1 derived from senescent FLSs induces chondrocyte mitochondrial dysfunction via modulating NRF2/SIRT3 axis in osteoarthritis progression
Xiang Chen, Wang Gong, Pan Zhang, Chengzhi Wang, Bin Liu, Xiaoyan Shao, Yi He, Na Liu, Jiaquan Lin, Jianghui Qin, Qing Jiang, Baosheng Guo,
2025, 15(11):5803-5816. DOI:10.1016/j.apsb.2025.08.014
Abstract
Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies
Yunqiang Zhou, Yong Wang, Huiying Yang, Chi Zhang, Jian Meng, Lingliang Zhang, Kun Li, Ling-ling Huang, Xian Zhang, Hong Luo, Yunwu Zhang,
2025, 15(11):5817-5831. DOI:10.1016/j.apsb.2025.09.024
Abstract
High glucose induces hippocampal neuron impairment through the SKP1/COX7C pathway: A potential mechanism for perimenopausal depression
Ziqi Wang, Zhiyuan Liu, Sijia Feng, Xintong Song, Dequan Liu, Ning Ma, Xinyue Zhang, Weiwei Liu, Dan Ohtan Wang, Xiaoling Liu, Takashi Ikejima,
2025, 15(11):5832-5853. DOI:10.1016/j.apsb.2025.09.003
Abstract
A promising novel local anesthetic for effective anesthesia in oral inflammatory conditions through reducing mitochondria-related apoptosis
Haofan Wang, Yihang Hao, Wenrui Gai, Shilong Hu, Wencheng Liu, Bo Ma, Rongjia Shi, Yongzhen Tan, Ting Kang, Ao Hai, Yi Zhao, Yaling Tang, Ling Ye, Jin Liu, Xinhua Liang, Bowen Ke,
2025, 15(11):5854-5866. DOI:10.1016/j.apsb.2025.09.001
Abstract
A small-molecule anti-cancer drug for long-acting lysosomal damage
Shulin Zhao, Qingjie Bai, Guimin Xue, Juan Wang, Luyao Hu, Xueqian Wang, Yan Li, Shuai Lu, Yangang Sun, Zhiqiang Zhang, Yanling Mu, Yanle Zhi, Qixin Chen,
2025, 15(11):5867-5879. DOI:10.1016/j.apsb.2025.09.005
Abstract
Deciphering the significant impact of natural glycosylation on human insulin
Yaohao Li, Wenqiang Liu, Dan Liu, Ruihan Wang, Yajing Zhang, Xin Li, Jinyuan Gong, Shiying Shang, Zhongping Tan,
2025, 15(11):5880-5890. DOI:10.1016/j.apsb.2025.08.005
Abstract
Ferrum@albumin assembled nanoclusters inhibit NF-κB signaling pathway for NIR enhanced acute lung injury immunotherapy
Xiaoxuan Guan, Binbin Zou, Weiqian Jin, Yan Liu, Yongfeng Lan, Jing Qian, Juan Luo, Yanjun Lei, Xuzhi Liang, Shiyu Zhang, Yuting Xiao, Yan Long, Chen Qian, Chaoyu Huang, Weili Tian, Jiahao Huang, Yongrong Lai, Ming Gao, Lin Liao,
2025, 15(11):5891-5907. DOI:10.1016/j.apsb.2025.08.012
Abstract
DNAzyme targeting RIP3 suppresses NLRP3-mediated necroinflammation for the treatment of inflammatory diseases
Jiaxin Jia, Hugang Zhang, Guangxu Fang, Yang Li, Kai Wen, Hanyu Liu, Haobo Han, Quanshun Li,
2025, 15(11):5908-5932. DOI:10.1016/j.apsb.2025.09.002
Abstract
A self-cascade nanoCRISPR prompts transcellular penetration to potentiate gene editing and tumor killing
Chao Liu, Yangsong Xu, Ning Wang, Hongyu Liu, Xi Yang, Shiyao Zhou, Dongxue Huang, Yingjie Li, Yanjie You, Qinjie Wu, Changyang Gong,
2025, 15(11):5933-5944. DOI:10.1016/j.apsb.2025.09.004
Abstract
Pulmonary surfactant-biomimetic membranized coacervate injection for acute respiratory distress syndrome therapy
Wei Chen, Qi Xie, Zhanhao Zhou, Jia Kang, Yuan Gao, Haoyu Zhang, Samira Batur, Chuansheng Fu, Yunyun Li, Conglian Yang, Li Kong, Zhiping Zhang,
2025, 15(11):5945-5965. DOI:10.1016/j.apsb.2025.08.025
Abstract
Microneedle-facilitated Portulaca oleracea L.-derived nanovesicles ameliorate atopic dermatitis by modulating macrophage M1/M2 polarization and inhibiting NF-κB and STING signaling pathways
Meng Long, Jiaqi Li, Yuecheng Zhu, Hang Ruan, Jing Li, Fanjun Xu, Ruipeng Liu, Tao Yang, Yanqin Shi, Nianping Feng, Yongtai Zhang,
2025, 15(11):5966-5987. DOI:10.1016/j.apsb.2025.08.021
Abstract
Electrochemical biosensors with right-side-out-oriented cell membrane coating for the evaluation of AChE inhibitors as potential anti-Alzheimer's disease agents
Ying Zhao, Xia Liu, Shuning Yang, Jiabo Wang, Dan Wu, Yusi Bu, Xiaoyu Xie,
2025, 15(11):5988-6000. DOI:10.1016/j.apsb.2025.09.032
Abstract
Arsenic trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis
Shengmei Wang, Ding Ma, Minghua Yang, Ye Zhang, Shengfeng Wang, Wenhu Zhou,
2025, 15(11):6001-6018. DOI:10.1016/j.apsb.2025.08.003
Abstract
Engineered Escherichia coli Nissle 1917 targeted delivery of extracellular PD-L1-mFc fragment for treating inflammatory bowel disease
Yuhong Wang, Lin Hu, Lei Wang, Chonghai Zhang, Wenhao Shen, Hongli Yang, Min Li, Xin Zhang, Mengmeng Xu, Muxing Zhang, Kai Yang, Xiaopeng Tian,
2025, 15(11):6019-6033. DOI:10.1016/j.apsb.2025.08.002
Abstract
A thermo-sensitive hydrogel targeting macrophage reprogramming for sustained osteoarthritis pain relief
Yue Liu, Kai Zhou, Xinlong He, Kun Shi, Danrong Hu, Chenli Yang, Jinrong Peng, Yuqi He, Guoyan Zhao, Yi Kang, Yujun Zhang, Yue'e Dai, Min Zeng, Feier Xian, Wensheng Zhang, Zhiyong Qian,
2025, 15(11):6034-6051. DOI:10.1016/j.apsb.2025.07.024
Abstract
Orally deliverable biomimetic nucleic acid therapies for targeted treatment of atherosclerosis
Chenwen Li, Yidan Chen, Yuan Li, Huan Liu, Shengqian Yang, Yongyao Lin, Yuantong Qi, Songling Han, Yin Dou, Gaoxing Luo, Yingxue Hao, Jianxiang Zhang,
2025, 15(11):6052-6069. DOI:10.1016/j.apsb.2025.07.039
Abstract
Tertiary lymphoid structures: The touchstone for tumor immunotherapy
Lisha Zhou, Shunji Liu, Yang Sun,
2025, 15(11):6070-6072. DOI:10.1016/j.apsb.2025.09.027
Abstract
Amino acid restriction in obesity management: Inducing energy discharge
Lili Yu, Jianping Ye,
2025, 15(11):6073-6075. DOI:10.1016/j.apsb.2025.07.013
Abstract
Protein degradation-based anti-infective drug research
Dazhou Shi, Shujing Xu, Xu Deng, Yundong Sun, Peng Zhan,
2025, 15(11):6076-6081. DOI:10.1016/j.apsb.2025.08.024
Abstract
Unlocking the potential of targeted protein degradation via nanoparticle-based universal strategy
Ti-Qiang Zhou, Weilun Sun, Zhen-Zhen Wei, Yuhua Weng, Dongxu Zhao, Mengjie Zhang, Yuanyu Huang,
2025, 15(11):6082-6086. DOI:10.1016/j.apsb.2025.09.016
Abstract
AT-17 redefines local anesthetics by targeting mitochondrial apoptosis
Xiaoyuan Chen,
2025, 15(11):6087-6088. DOI:10.1016/j.apsb.2025.10.013
Abstract
From single-thread delivery to cascading therapy: The promise of nanoCRISPR in solid tumors
Peng Mi, Horacio Cabral,
2025, 15(11):6089-6090. DOI:10.1016/j.apsb.2025.10.015
Abstract
Author correction to “Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors” [Acta Pharm Sin B 12 (2022) 952–966]
Mengchi Sun, Hailun Jiang, Tian Liu, Xiao Tan, Qikun Jiang, Bingjun Sun, Yulong Zheng, Gang Wang, Yang Wang, Maosheng Cheng, Zhonggui He, Jin Sun,
2025, 15(11):6091-6092. DOI:10.1016/j.apsb.2025.09.034
Abstract