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How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance
Jiawei Song, Lu Ye, Wei-Qun Ding, Huaijin Qiao, Junlong Dai, Hao Bai, Shuyu Zhang,
2025, 15(12):6093-6140. DOI:10.1016/j.apsb.2025.09.019
Abstract
Emerging epigenetic modifications in renal fibrosis: From mechanisms to treatments
Xiaoguo Suo, Qinglin Ge, Lijin Peng, Qi Zhu, Mengmeng Zhang, Xinran Cheng, Fang Wang, Juan Jin, Jianan Wang, Xiaoming Meng,
2025, 15(12):6141-6162. DOI:10.1016/j.apsb.2025.09.012
Abstract
Graph neural networks driven acceleration in drug discovery
Rui Wang, Chunlin Zhuang,
2025, 15(12):6163-6177. DOI:10.1016/j.apsb.2025.10.011
Abstract
m6A readers: Promising therapeutic targets in cancer treatment
Xinyue Wang, Xuetao Chen, Shuai Wen, Yi Mou, Xiaoke Guo, Zhengyu Jiang,
2025, 15(12):6178-6198. DOI:10.1016/j.apsb.2025.10.004
Abstract
Artificial intelligence for radiopharmaceutical and molecular imaging
Jinping Tao, Ling Liang, Siqi Hao, Yan Chen, Zhi Yang, Yimao Cai, Hua Zhu,
2025, 15(12):6199-6221. DOI:10.1016/j.apsb.2025.09.039
Abstract
Recent advances in engineering nano/microrobots for tumor treatment
Xifeng Qin, Ruizhe Xu, Jiayi Wu, Yue Liu, Ting Wang, Hongyan Tu, Jia Li, Zhiqing Pang,
2025, 15(12):6222-6252. DOI:10.1016/j.apsb.2025.10.003
Abstract
Site-specific PEGylation of proteins: Insights into structural and functional changes
Ming Ma, Jinwei Di, Chengcai Wang, Yanwei Xie, Fengqian Cui, Yanan Zhai, Shanwei Zhu, Jing Gao,
2025, 15(12):6253-6273. DOI:10.1016/j.apsb.2025.10.014
Abstract
ROS-scavenging nanomaterials as emerging tools for bone tissue regeneration: A comprehensive review of recent progress
Wanzhuo He, Tian Xu, Miao Wang, Ni Ni, Yun Su, Xianqun Fan,
2025, 15(12):6274-6306. DOI:10.1016/j.apsb.2025.09.040
Abstract
Ferroptosis meets cancer immunotherapy: Overcoming the crosstalk challenges through advanced drug delivery strategies
Lu Gan, Xincheng Lin, Ziqiao Zhong, Yichun Zheng, Xinyi Chen, Jun Chen, Xiao Yue, Yingshan Liu, Xin Pan, Chuanbin Wu, Ying Huang, Wenhao Wang,
2025, 15(12):6307-6341. DOI:10.1016/j.apsb.2025.09.043
Abstract
Progress in peptide and protein therapeutics: Challenges and strategies
Mengyang Liu, Darren Svirskis, Thomas Proft, Jacelyn Loh, Naibo Yin, Hao Li, Danhui Li, Yongzhi Zhou, Shuo Chen, Lizhuo Song, Guanyu Chen, Wei-Yue Lu, Zhiwen Zhang, Zhou Zhou, Lian Li, Yuan Huang, Craig Bunt, Guiju Sun, Paul W. R. Harris, Margaret A. Brimble, Jingyuan Wen,
2025, 15(12):6342-6381. DOI:10.1016/j.apsb.2025.10.026
Abstract
Generation and applications of an expandable and mature hiPSC-derived liver organoid
Sen Liu, Ze Wang, Liuyang Zhu, Libo Wang, Tianyu Zhao, Pinsheng Han, Yongdeng Xu, Long Yang, Lei Hu, Fengying Yan, Xiaoliang Wang, Tao Cui, Chunli Li, Baofeng Yang,
2025, 15(12):6382-6398. DOI:10.1016/j.apsb.2025.09.029
Abstract
Glutamine synthetase in astrocytes of the caudate and putamen is responsible for locomotor sensitization after nicotine exposure
Ju Hwan Yang, Sumin Sohn, Sunghyun Kim, Jieun Kim, Su Yeon Seo, Aqsa Kazmi, Hanwoong Woo, John Q. Wang, Eun Sang Choe,
2025, 15(12):6399-6414. DOI:10.1016/j.apsb.2025.09.038
Abstract
MYD88 regulates the intercellular crosstalk landscape in MASH liver against metaflammation and metabolic disorder
Haonan Li, Daimin Luo, Chuangnan Qiu, Xianzhi Wei, Mengzhu Wu, Rui Wang, Xianyan Liu, Xianxing Jiang,
2025, 15(12):6415-6429. DOI:10.1016/j.apsb.2025.09.041
Abstract
Elevated SNHG15 empowers keratinocytes hyperproliferation through activation of STAT3/Cyclin D1 axis in psoriasis
Lipeng Tang, Guanzhuo Li, Jiameng Chang, Haiyan Xian, Yanjie Liu, Luping Lin, Zixin Dai, Zhenting Liu, Xinmin Qiu, Bowen Zhang, Zuqing Su, Bing Feng, Ying Zhu, Maojie Wang, Yuchao Chen, Huazhen Liu, Dinghong Wu, Chutian Li, Jie Zhao, Mingxian Li, Yongzhan Zhu, Xingyi Xie, Hao Deng, Shuyan Ye, Shicheng Fan, Huichang Bi, Chuanjian Lu, Guangjuan Zheng,
2025, 15(12):6430-6443. DOI:10.1016/j.apsb.2025.10.010
Abstract
The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer
Wei Xu, Minmin Shen, Junjie Ma, Chuanlin Peng, Shanshan Wu, Xinxin Yang, Jiahe Wu, Youyou Yan, Nengming Lin, Jianqing Gao, Bo Zhang,
2025, 15(12):6444-6460. DOI:10.1016/j.apsb.2025.09.042
Abstract
THBru ameliorates atherosclerosis by inhibiting endothelial ferroptosis via regulation of the super-enhancer-associated ABCC1
Jing Feng, Yingying Hu, Xiuxiu Sun, Yutong Hao, Yiyang Li, Qiang Huang, Yanli Xie, Jin Gao, Ange Hu, Yang Hong, Xu Wang, Heng Liu, Zijia Dou, Lina Yao, Qi Lu, Jennifer Wang, Philipp Kopylov, Weina Han, Yong Zhang, Xin Liu,
2025, 15(12):6461-6477. DOI:10.1016/j.apsb.2025.09.035
Abstract
IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules
Xuanlin Su, Jiankun Zang, Yaping Wang, Shiqing Zhang, Panwen Wu, Wei Chen, Lei Shi, Yousheng Wu, Die Deng, Kaiwei Cai, Hongcheng Mai, Anding Xu, Dan Lu,
2025, 15(12):6478-6494. DOI:10.1016/j.apsb.2025.08.013
Abstract
Undulanoids A-D: Unexpected sesterterpenoids as potent S100A8/A9 complex inhibitors for psoriasis treatment
Yuyi Zheng, Xiaotian Zhang, Xiaoxia Gu, Yongqi Li, Qin Li, Yingli Zhu, Bingbing Dai, Yu Liang, Ruping Fan, Chunmei Chen, Weiguang Sun, Yonghui Zhang, Hucheng Zhu,
2025, 15(12):6495-6509. DOI:10.1016/j.apsb.2025.09.006
Abstract
Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy
Yu Guo, Yi Song, Hanlin Wang, Yang Lu, Jingyu Zhang, Zheyuan Shen, Weijuan Kan, Yuxian Wang, Haiting Duan, Shuangshuang Geng, Bo Wang, Shaoting Li, Bizhi Li, Xi Chen, Shanshan Pei, Luo Fang, Jia Li, Yubo Zhou, Jinxin Che, Xiaowu Dong,
2025, 15(12):6510-6528. DOI:10.1016/j.apsb.2025.09.009
Abstract
Discovery of peptidomimetic inhibitors of CREB/CBP by targeting hydrophobic grooves on the surface of the CBP KIX domain
Bo Huang, Emily Gregory-Lott, Bingbing X. Li, Timothy H. Tran, Sihao Li, Menglin Xue, Shaohui Wang, Anabanadam Asokan, Ning Shen, Xingming Sun, Chuanhai Cao, Xiangshu Xiao, Gary Daughdrill, Jianfeng Cai,
2025, 15(12):6529-6545. DOI:10.1016/j.apsb.2025.08.023
Abstract
Key imidazolyl groups that induce phenylalanine flipping enhance the efficacy of oral BRD9 inhibitors for AML treatment
Zhiming Chen, Cheng Zhang, Hui Shen, Hongrui Xu, Yumin Huang, Ruibo Dong, Xin Tang, Shuang Chai, Junhua Li, Jinxin Xu, Xiaohan Zhang, Yan Zhang, Xishan Wu, Yong Xu,
2025, 15(12):6546-6570. DOI:10.1016/j.apsb.2025.08.006
Abstract
Probiotic living microneedles designed by interbacterial competition for accelerated infected wound healing
Honglei Wang, Zibei Wu, Chen Gao, Wenhao Wang, Minglong Chen, Lin Yuan, Jiating Wang, Cairong Xiao, Yang Zhou, Fan Tong, Hanmei Li, Huile Gao, Xiang Gao, Jintao Fu,
2025, 15(12):6571-6586. DOI:10.1016/j.apsb.2025.10.029
Abstract
Butyrylated Smilax glabra starch relieves atopic dermatitis through gut-skin axis modulation via colon-targeted delivery
Nan Wang, Lingling Wu, Yaya Su, Chi Zhang, Xu Chen, Hailong Yuan,
2025, 15(12):6587-6606. DOI:10.1016/j.apsb.2025.10.012
Abstract
Targeting renal tubular epithelial cells via a dual functionalized oligosaccharide self-assembly in the management of acute and chronic kidney diseases
Yingying Xu, Jiajia Gui, Yunxiao Zhang, Simin Nan, Yujie Che, Xi Cao, Xianjun Fang, Tao Gong, Zhirong Zhang, Yao Fu,
2025, 15(12):6607-6625. DOI:10.1016/j.apsb.2025.09.017
Abstract
Hemoglobin nanocatalyst with tunable autoxidation activity for tumor apoptosis-ferroptosis combination therapy
Jing Li, Hongbo Wu, Hanyue Li, Yue Zhang, Hanjie Zhang, Ling Wang, Weilang Zhang, Tingxuan Li, Weiwei Zeng, Daquan Chen, Lin Mei,
2025, 15(12):6626-6637. DOI:10.1016/j.apsb.2025.09.031
Abstract
Injectable hydrogel-mediated co-delivery of oncolytic adenovirus and melphalan for retinoblastoma control and vision preservation
Guoqing Wang, Kai Wu, Zongliang Zhang, Yongdong Chen, Yanfang Li, Xiaoshuang Jiang, Licong Liang, Yiliu Yang, Hongsong Fan, Jing Sun, Aiping Tong, Fang Lu,
2025, 15(12):6638-6656. DOI:10.1016/j.apsb.2025.09.030
Abstract
LSD1 inhibition sensitizes anti-PD1 blockade immunotherapy by inhibiting the long-range attack of tumor-derived extracellular vesicles
Yu Zhao, Danyang Zhang, Lin Meng, Siming Shan, Chao Zhang, Zhenzhong Deng, Chao Han, Lingyi Kong,
2025, 15(12):6657-6680. DOI:10.1016/j.apsb.2025.10.030
Abstract
RDYH58 functional exosomes targeting myofibroblasts loaded with siFKBP10 for inhibition of collagen biosynthesis and secretion of IPF
Ranran Yuan, Zhen Mu, Houqian Zhang, Yu Tian, Quanlin Xin, Qingchao Tu, Yan Zhang, Yanqiu Li, Zhiwen Zhang, Yongchao Chu, Aiping Wang, Jingwei Tian, Hongbo Wang, Chong Qiu, Yanan Shi,
2025, 15(12):6681-6697. DOI:10.1016/j.apsb.2025.08.017
Abstract
Standardization of nasal airway structure model of Chinese Han nationality for characterization of nasal formulation spatial deposition atlases
Zeru Li, Huipeng Xu, Siwen Wang, Qin Nie, Bingqian Jia, Jiawen Su, Guanghong Xu, Rui Yang, Zhigang Wang, Jiwen Zhang, Li Wu,
2025, 15(12):6698-6713. DOI:10.1016/j.apsb.2025.09.018
Abstract
Development of a novel 18F-labeled reversible-binding radioligand for imaging monoacylglycerol lipase with positron emission tomography
Jian Rong, Chunyu Zhao, Ahmad F. Chaudhary, Tim Ware, Richard S. Van, Yinlong Li, Erick R. Calderon Leon, Vivi Dang, Jiahui Chen, Zhiwei Xiao, Xin Zhou, Wei Zhang, Chunyang Bi, Kuo Zhang, Jimmy S. Patel, Yihan Shao, Chongzhao Ran, Ludovic Collin, Achi Haider, Benjamin F. Cravatt, Steven H. Liang,
2025, 15(12):6714-6726. DOI:10.1016/j.apsb.2025.05.041
Abstract
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative
Yuanguang Chen, Yongqing Liu, Guanguan Li, Chao Peng, Dizhen Liang, Sidi Yang, Peisen Zheng, Shuo Li, Deyin Guo, Qifan Zhou, Xumu Zhang,
2025, 15(12):6727-6730. DOI:10.1016/j.apsb.2025.08.027
Abstract
Neuroimmune circuit mediates apathy in cancer cachexia
Yongrui Hai, Renming Fan, Fangfang Qi, Minggao Zhao, Gaofei Wei,
2025, 15(12):6731-6734. DOI:10.1016/j.apsb.2025.10.009
Abstract
Decoding helical dynamics in viral replication: Cryo-EM unveils conserved assembly mechanisms and broad-spectrum antiviral targets
Bo Wang, Jiwei Zhang, Xinyong Liu, Peng Zhan,
2025, 15(12):6735-6738. DOI:10.1016/j.apsb.2025.08.026
Abstract
CELMoD-antibody conjugates unlock a CD38 feedback loop in multiple myeloma
Jian Jin,
2025, 15(12):6739-6740. DOI:10.1016/j.apsb.2025.11.017
Abstract
New leap of BRD9 inhibitor: Imidazole substituents making BRD9 inhibitors excellent drug candidates for AML
Edward Zhou,
2025, 15(12):6741-6742. DOI:10.1016/j.apsb.2025.11.018
Abstract
Author correction to “AI-integrated IQPD framework of quality prediction and diagnostics in small-sample multi-unit pharmaceutical manufacturing: advancing from experience-driven to data-driven manufacturing” [Acta Pharm Sin B 15 (2025) 4193-4209]
Kaiyi Wang, Xinhai Chen, Nan Li, Huimin Feng, Xiaoyi Liu, Yifei Wang, Yanfei Wu, Yufeng Guo, Shuoshuo Xu, Lu Yao, Zhaohua Zhang, Jun Jia, Zhishu Tang, Zhisheng Wu,
2025, 15(12):6743-6744. DOI:10.1016/j.apsb.2025.10.017
Abstract