column
Safety, pharmacokinetics, and dosimetry of 177Lu-AB-3PRGD2 in patients with advanced integrin αvβ3-positive tumors: A first-in-human study
Huimin Sui, Feng Guo, Hongfei Liu, Rongxi Wang, Linlin Li, Jiarou Wang, Chenhao Jia, Jialin Xiang, Yingkui Liang, Xiaohong Chen, Zhaohui Zhu, Fan Wang,
2025, 15(2):669-680. DOI:10.1016/j.apsb.2024.10.012
Abstract
l-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis
Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, Rui Luo, Feng Wang, Kuan Hu, Ming-Rong Zhang,
2025, 15(2):681-691. DOI:10.1016/j.apsb.2024.07.023
Abstract
Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance
Siqi Zhang, Xiaohui Ma, Jiang Wu, Jieting Shen, Yuntao Shi, Xingkai Wang, Lin Xie, Xiaona Sun, Yuxuan Wu, Hao Tian, Xin Gao, Xueyao Chen, Hongyi Huang, Lu Chen, Xuekai Song, Qichen Hu, Hailong Zhang, Feng Wang, Zhao-Hui Jin, Ming-Rong Zhang, Rui Wang, Kuan Hu,
2025, 15(2):692-706. DOI:10.1016/j.apsb.2024.07.006
Abstract
Safety, dosimetry, and efficacy of an optimized long-acting somatostatin analog for peptide receptor radionuclide therapy in metastatic neuroendocrine tumors: From preclinical testing to first-in-human study
Wei Guo, Xuejun Wen, Yuhang Chen, Tianzhi Zhao, Jia Liu, Yucen Tao, Hao Fu, Hongjian Wang, Weizhi Xu, Yizhen Pang, Liang Zhao, Jingxiong Huang, Pengfei Xu, Zhide Guo, Weibing Miao, Jingjing Zhang, Xiaoyuan Chen, Haojun Chen,
2025, 15(2):707-721. DOI:10.1016/j.apsb.2024.05.022
Abstract
Synthesis and evaluation of TSPO-targeting radioligand [18F]F-TFQC for PET neuroimaging in epileptic rats
Wenhui Fu, Qingyu Lin, Zhequan Fu, Tingting Yang, Dai Shi, Pengcheng Ma, Hongxing Su, Yunze Wang, Guobing Liu, Jing Ding, Hongcheng Shi, Dengfeng Cheng,
2025, 15(2):722-736. DOI:10.1016/j.apsb.2024.05.031
Abstract
Resistance to antibody–drug conjugates: A review
Sijia Li, Xinyu Zhao, Kai Fu, Shuangli Zhu, Can Pan, Chuan Yang, Fang Wang, Kenneth K. W. To, Liwu Fu,
2025, 15(2):737-756. DOI:10.1016/j.apsb.2024.12.036
Abstract
Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases
Wei-Qing Deng, Zi-Han Ye, Zhenghai Tang, Xiao-Lei Zhang, Jin-Jian Lu,
2025, 15(2):757-791. DOI:10.1016/j.apsb.2024.11.018
Abstract
Dendritic cells immunotargeted therapy for atherosclerosis
Zhaohui Li, Yanyan Yang, Jinbao Zong, Bei Zhang, Xiaolu Li, Hongzhao Qi, Tao Yu, Yongxin Li,
2025, 15(2):792-808. DOI:10.1016/j.apsb.2024.12.029
Abstract
Drug delivery systems based on mesoporous silica nanoparticles for the management of hepatic diseases
Boyan Liu, Wenshi Liu, Miao Xu, Tongyi Zhao, Bingxin Zhou, Ruilin Zhou, Ze Zhu, Xuchun Chen, Zhiye Bao, Keke Wang, Heran Li,
2025, 15(2):809-833. DOI:10.1016/j.apsb.2024.12.015
Abstract
Size-transformable nanotherapeutics for cancer therapy
Teng Ma, Tuyen Ba Tran, Ethan Lin, Stephanie Hunt, Riley Haveman, Kylie Castro, Jianqin Lu,
2025, 15(2):834-851. DOI:10.1016/j.apsb.2024.11.012
Abstract
Nanomaterials evoke pyroptosis boosting cancer immunotherapy
Zhenhua Li, Ziyue Xi, Chuanyong Fan, Xinran Xi, Yao Zhou, Ming Zhao, Lu Xu,
2025, 15(2):852-875. DOI:10.1016/j.apsb.2024.11.011
Abstract
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
Yuyu Zhu, Lixin Zhao, Wei Yan, Hongyue Ma, Wanjun Zhao, Jiao Qu, Wei Zheng, Chenyang Zhang, Haojie Du, Meng Yu, Ning Wan, Hui Ye, Yicheng Xie, Bowen Ke, Qiang Xu, Haiyan Sun, Yang Sun, Zijun Ouyang,
2025, 15(2):876-891. DOI:10.1016/j.apsb.2024.12.041
Abstract
Intestinal stearoyl-coenzyme A desaturase-inhibition improves obesity-associated metabolic disorders
Yangliu Xia, Yang Zhang, Zhipeng Zhang, Nana Yan, Vorthon Sawaswong, Lulu Sun, Wanwan Guo, Ping Wang, Kristopher W. Krausz, Oksana Gavrilova, James M. Ntambi, Haiping Hao, Tingting Yan, Frank J. Gonzalez,
2025, 15(2):892-908. DOI:10.1016/j.apsb.2024.11.022
Abstract
Integrated evidence chain-based effectiveness evaluation of traditional Chinese medicines (Eff-iEC): A demonstration study
Ye Luo, Xu Zhao, Ruilin Wang, Xiaoyan Zhan, Tianyi Zhang, Tingting He, Jing Jing, Jianyu Li, Fengyi Li, Ping Zhang, Junling Cao, Jinfa Tang, Zhijie Ma, Tingming Shen, Shuanglin Qin, Ming Yang, Jun Zhao, Zhaofang Bai, Jiabo Wang, Aiguo Dai, Xiangmei Chen, Xiaohe Xiao,
2025, 15(2):909-918. DOI:10.1016/j.apsb.2024.12.024
Abstract
P2Y14R activation facilitates liver regeneration via CREB/DNMT3b/Dact-2/β-Catenin signals in acute liver failure
Mengze Zhou, Yehong Li, Jialong Qian, Xinli Dong, Yanshuo Guo, Li Yin, Chunxiao Liu, Kun Hao, Qinghua Hu,
2025, 15(2):919-933. DOI:10.1016/j.apsb.2025.01.004
Abstract
Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates
Dongrong Yi, Yongxin Zhang, Jing Wang, Qian Liu, Ling Ma, Quanjie Li, Saisai Guo, Ruifang Zheng, Xiaoyu Li, Xingong Li, Yijie Dong, Shuaiyao Lu, Weiguo Zhang, Xiaozhong Peng, Shan Cen,
2025, 15(2):934-946. DOI:10.1016/j.apsb.2024.12.003
Abstract
Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
Yi Wu, Xiaoying Jia, Namei Wu, Xinghai Zhang, Yan Wu, Yang Liu, Minmin Zhou, Yanqiong Shen, Entao Li, Wei Wang, Jiaming Lan, Yucai Wang, Sandra Chiu,
2025, 15(2):947-962. DOI:10.1016/j.apsb.2024.12.030
Abstract
Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity
Yin Zhu, Yuyin Wang, Keito Hoshitsuki, Da Yang, Lauren Kokai, Xiaochao Ma, Wen Xie, Christian A. Fernandez,
2025, 15(2):963-972. DOI:10.1016/j.apsb.2024.11.002
Abstract
FLZ attenuates Parkinson's disease pathological damage by increasing glycoursodeoxycholic acid production via down-regulating Clostridium innocuum
Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang,
2025, 15(2):973-990. DOI:10.1016/j.apsb.2024.10.011
Abstract
A small molecule cryptotanshinone induces non-enzymatic NQO1-dependent necrosis in cancer cells through the JNK1/2/Iron/PARP/calcium pathway
Ying Hou, Bingling Zhong, Lin Zhao, Heng Wang, Yanyan Zhu, Xianzhe Wang, Haoyi Zheng, Jie Yu, Guokai Liu, Xin Wang, Jose M. Martin-Garcia, Xiuping Chen,
2025, 15(2):991-1006. DOI:10.1016/j.apsb.2024.12.005
Abstract
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway
Xuanzuo Chen, Sheng Liu, Huiwen Wang, Yiran Liu, Yan Xiao, Kanglu Li, Feifei Ni, Wei Wu, Hui Lin, Xiangcheng Qing, Feifei Pu, Baichuan Wang, Zengwu Shao, Yizhong Peng,
2025, 15(2):1007-1022. DOI:10.1016/j.apsb.2024.12.013
Abstract
GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway
Chunyan Dong, Bailing Zhou, Binyan Zhao, Ke Lin, Yaomei Tian, Rui Zhang, Daoyuan Xie, Siwen Wu, Li Yang,
2025, 15(2):1023-1038. DOI:10.1016/j.apsb.2024.12.006
Abstract
Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation via deubiquitination of IMPDH2 in macrophages
Xin Liu, Yi Fang, Mincong Huang, Shiliang Tu, Boan Zheng, Hang Yuan, Peng Yu, Mengyao Lan, Wu Luo, Yongqiang Zhou, Guorong Chen, Zhe Shen, Yi Wang, Guang Liang,
2025, 15(2):1039-1055. DOI:10.1016/j.apsb.2024.12.012
Abstract
Synthesis, preclinical evaluation and pilot clinical study of a P2Y12 receptor targeting radiotracer [18F]QTFT for imaging brain disorders by visualizing anti-inflammatory microglia
Bolin Yao, Yanyan Kong, Jianing Li, Fulin Xu, Yan Deng, Yuncan Chen, Yixiu Chen, Jian Chen, Minhua Xu, Xiao Zhu, Liang Chen, Fang Xie, Xin Zhang, Cong Wang, Cong Li,
2025, 15(2):1056-1069. DOI:10.1016/j.apsb.2025.01.009
Abstract
A novel anti-ischemic stroke candidate drug AAPB with dual effects of neuroprotection and cerebral blood flow improvement
Jianbing Wu, Duorui Ji, Weijie Jiao, Jian Jia, Jiayi Zhu, Taijun Hang, Xijing Chen, Yang Ding, Yuwen Xu, Xinglong Chang, Liang Li, Qiu Liu, Yumei Cao, Yan Zhong, Xia Sun, Qingming Guo, Tuanjie Wang, Zhenzhong Wang, Ya Ling, Wei Xiao, Zhangjian Huang, Yihua Zhang,
2025, 15(2):1070-1083. DOI:10.1016/j.apsb.2024.12.042
Abstract
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer
Shizhen Geng, Tingting Xiang, Yaru Shi, Mengnian Cao, Danyu Wang, Jing Wang, Xinling Li, Haiwei Song, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Airong Li, Ke Sun,
2025, 15(2):1084-1097. DOI:10.1016/j.apsb.2025.01.002
Abstract
Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease
Ya Wei, Xue Xia, Xiaorong Wang, Wenqin Yang, Siqin He, Lulu Wang, Yongke Chen, Yang Zhou, Feng Chen, Hanmei Li, Fu Peng, Guobo Li, Zheng Xu, Jintao Fu, Huile Gao,
2025, 15(2):1098-1111. DOI:10.1016/j.apsb.2025.01.015
Abstract
NO-releasing double-crosslinked responsive hydrogels accelerate the treatment and repair of ischemic stroke
Wen Guo, Cheng Hu, Yue Wang, Wen Zhang, Shaomin Zhang, Jin Peng, Yunbing Wang, Jinhui Wu,
2025, 15(2):1112-1125. DOI:10.1016/j.apsb.2025.01.005
Abstract
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy
Lijun Su, Yixi Zhu, Xuebo Li, Di Wang, Xiangyu Chen, Zhen Liu, Jingjing Li, Chen Zhang, Jinming Zhang,
2025, 15(2):1126-1142. DOI:10.1016/j.apsb.2024.12.020
Abstract
Modulating active targeting nanoparticle design according to tumor progressions
Huifang Nie, Rong Huang, Guangwei Jiang, Wenshuai Li, Lan Yang, Meng Zhang, Min Qian, Wei Guo, Tao Ye, Rongqin Huang,
2025, 15(2):1143-1158. DOI:10.1016/j.apsb.2024.12.016
Abstract
NIR-II-activated whole-cell vaccine with ultra-efficient semiconducting diradical oligomers for breast carcinoma growth and metastasis inhibition
Yijian Gao, Yachao Zhang, Yujie Ma, Xiliang Li, Yu Wang, Huan Chen, Yingpeng Wan, Zhongming Huang, Weimin Liu, Pengfei Wang, Lidai Wang, Chun-Sing Lee, Shengliang Li,
2025, 15(2):1159-1170. DOI:10.1016/j.apsb.2024.12.017
Abstract
Engineering cellular dephosphorylation boosts (+)-borneol production in yeast
Haiyan Zhang, Peng Cai, Juan Guo, Jiaoqi Gao, Linfeng Xie, Ping Su, Xiaoxin Zhai, Baolong Jin, Guanghong Cui, Yongjin J. Zhou, Luqi Huang,
2025, 15(2):1171-1182. DOI:10.1016/j.apsb.2024.12.039
Abstract
Circadian clock regulates immune checkpoint inhibitor efficacy
Yining Niu, Motao Zhu,
2025, 15(2):1183-1185. DOI:10.1016/j.apsb.2025.01.011
Abstract
TransTACs: Transforming antibodies into targeted protein degraders
Yu Guo, Jinxin Che, Xiaowu Dong,
2025, 15(2):1186-1188. DOI:10.1016/j.apsb.2025.01.003
Abstract
Unlocking the healthy human microbiome: Redefining core microbial signatures
Shuting Xia, Diya Jiang, Qianyi Zhou, Hairong Lyu, Anita Y. Voigt, Xin Zhou, Zhemin Zhou, Yuan Huang,
2025, 15(2):1189-1192. DOI:10.1016/j.apsb.2025.01.001
Abstract
Neuronal activities drive brain waste clearance through the glymphatic system
Lin-jian Wang, Xiwen Ma, Jianping Ye,
2025, 15(2):1193-1195. DOI:10.1016/j.apsb.2024.11.005
Abstract
DELIVER: The core principles for the clinic translation of nanomedicines
Chuan Hu, Xinling He, Huile Gao, Jinming Zhang,
2025, 15(2):1196-1198. DOI:10.1016/j.apsb.2025.01.014
Abstract
Oral garlic-derived nanoparticles improve cancer immunotherapy
Kun Yang, Jinming Zhang, Bo Xiao,
2025, 15(2):1199-1201. DOI:10.1016/j.apsb.2024.12.021
Abstract
[18F]QTFT, a nicotinate-based radiotracer targeting P2Y12 with satisfactory blood‒brain barrier (BBB) permeability
Ying-Qi Song, Chunquan Sheng,
2025, 15(2):1202-1204. DOI:10.1016/j.apsb.2025.02.010
Abstract
Harnessing the UDP-G/P2Y14R axis to promote liver regeneration in acute liver failure
Jian-Hong Fang, Huichang Bi,
2025, 15(2):1205-1206. DOI:10.1016/j.apsb.2025.01.008
Abstract
Author correction to “Generation of αGal-enhanced bifunctional tumor vaccine” [Acta Pharm Sin B 12 (2022) 3177–3186]
Jian He, Yu Huo, Zhikun Zhang, Yiqun Luo, Xiuli Liu, Qiaoying Chen, Pan Wu, Wei Shi, Tao Wu, Chao Tang, Huixue Wang, Lan Li, Xiyu Liu, Yong Huang, Yongxiang Zhao, Lu Gan, Bing Wang, Liping Zhong,
2025, 15(2):1207-1207. DOI:10.1016/j.apsb.2024.11.021
Abstract
Author correction to “The novel ER stress inducer Sec C triggers apoptosis by sulfating ER cysteine residues and degrading YAP via ER stress in pancreatic cancer cells” [Acta Pharm Sin B 12 (2022) 210–227]
Junxia Wang, Minghua Chen, Mengyan Wang, Wenxia Zhao, Conghui Zhang, Xiujun Liu, Meilian Cai, Yuhan Qiu, Tianshu Zhang, Huimin Zhou, Wuli Zhao, Shuyi Si, Rongguang Shao,
2025, 15(2):1208-1209. DOI:10.1016/j.apsb.2024.10.013
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica