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Intravenous delivery of STING agonists using acid-sensitive polycationic polymer-modified lipid nanoparticles for enhanced tumor immunotherapy
Ying He, Ke Zheng, Xifeng Qin, Siyu Wang, Xuejing Li, Huiwen Liu, Mingyang Liu, Ruizhe Xu, Shaojun Peng, Zhiqing Pang,
2025, 15(3):1211-1229. DOI:10.1016/j.apsb.2024.06.004
Abstract
Bispecific killer engager for targeted depletion of PD-1 positive lymphocytes: A new avenue for autoimmune disease treatment
Lauren C. Naatz, Shuyun Dong, Brian Evavold, Xiangyang Ye, Mingnan Chen,
2025, 15(3):1230-1241. DOI:10.1016/j.apsb.2024.10.014
Abstract
Remodeling tumor immunosuppressive microenvironment through dual activation of immunogenic panoptosis and ferroptosis by H2S-amplified nanoformulation to enhance cancer immunotherapy
Yingli Luo, Maoyuan Linghu, Xianyu Luo, Dongdong Li, Jilong Wang, Shaojun Peng, Yinchu Ma,
2025, 15(3):1242-1254. DOI:10.1016/j.apsb.2024.12.014
Abstract
Disrupting calcium homeostasis and glycometabolism in engineered lipid-based pharmaceuticals propel cancer immunogenic death
Qiuxia Peng, Xiaolong Li, Chao Fang, Chunyan Zhu, Taixia Wang, Binxu Yin, Xiulin Dong, Huaijuan Guo, Yang Liu, Kun Zhang,
2025, 15(3):1255-1267. DOI:10.1016/j.apsb.2024.12.018
Abstract
The ubiquitin—proteasome system: A potential target for the MASLD
Yue Liu, Meijia Qian, Yonghao Li, Xin Dong, Yulian Wu, Tao Yuan, Jian Ma, Bo Yang, Hong Zhu, Qiaojun He,
2025, 15(3):1268-1280. DOI:10.1016/j.apsb.2025.01.010
Abstract
Comprehensive investigation of multiple targets in the development of newer drugs for the Alzheimer's disease
Patil Ashwini, Bodhankar Subhash, Muthal Amol, Dileep Kumar, Pawar Atmaram, Kulkarni Ravindra,
2025, 15(3):1281-1310. DOI:10.1016/j.apsb.2024.11.016
Abstract
Revolutionizing tuberculosis treatment: Breakthroughs, challenges, and hope on the horizon
Martin Kufa, Vladimir Finger, Ondrej Kovar, Ondrej Soukup, Carilyn Torruellas, Jaroslav Roh, Jan Korabecny,
2025, 15(3):1311-1332. DOI:10.1016/j.apsb.2025.01.023
Abstract
A retrospective cohort study of the efficacy and safety of oral azvudine versus nirmatrelvir/ritonavir in elderly hospitalized COVID-19 patients aged over 60 years
Bo Yu, Haiyu Wang, Guangming Li, Junyi Sun, Hong Luo, Mengzhao Yang, Yanyang Zhang, Ruihan Liu, Ming Cheng, Shixi Zhang, Guotao Li, Ling Wang, Guowu Qian, Donghua Zhang, Silin Li, Quancheng Kan, Jiandong Jiang, Zhigang Ren,
2025, 15(3):1333-1343. DOI:10.1016/j.apsb.2024.12.032
Abstract
Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features
You Wu, Ke Tang, Chunzheng Wang, Hao Song, Fanfan Zhou, Ying Guo,
2025, 15(3):1344-1358. DOI:10.1016/j.apsb.2025.02.009
Abstract
Targeting farnesoid X receptor as aging intervention therapy
Lijun Zhang, Jing Yu, Xiaoyan Gao, Yingxuan Yan, Xinyi Wang, Hang Shi, Minglv Fang, Ying Liu, Young-Bum Kim, Huanhu Zhu, Xiaojun Wu, Cheng Huang, Shengjie Fan,
2025, 15(3):1359-1382. DOI:10.1016/j.apsb.2025.01.006
Abstract
Long-chain acylcarnitine deficiency promotes hepatocarcinogenesis
Kaifeng Wang, Zhixian Lan, Heqi Zhou, Rong Fan, Huiyi Chen, Hongyan Liang, Qiuhong You, Xieer Liang, Ge Zeng, Rui Deng, Yu Lan, Sheng Shen, Peng Chen, Jinlin Hou, Pengcheng Bu, Jian Sun,
2025, 15(3):1383-1396. DOI:10.1016/j.apsb.2025.01.017
Abstract
Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME “two-hit” in mice
Jiahui Chen, Liping Zhang, Ting Xie, Xiao Zhang, Congcong Pan, Fangli Sun, Wenfeng Li, Zhijie Sun, Deli Dong,
2025, 15(3):1397-1414. DOI:10.1016/j.apsb.2024.12.040
Abstract
Effective therapeutic targeting of tumor lineage plasticity in neuroendocrine prostate cancer by BRD4 inhibitors
Xiong Zhang, Yatian Yang, Hongye Zou, Yang Yang, Xingling Zheng, Eva Corey, Amina Zoubeidi, Nicolas Mitsiades, Ai-Ming Yu, Yuanpei Li, Hong-Wu Chen,
2025, 15(3):1415-1429. DOI:10.1016/j.apsb.2025.01.007
Abstract
Parabacteroides distasonis promotes liver regeneration by increasing β-hydroxybutyric acid (BHB) production and BHB-driven STAT3 signals
Manlan Guo, Xiaowen Jiang, Hui Ouyang, Xianglong Zhang, Shuaishuai Zhang, Peng Wang, Guofang Bi, Ting Wu, Wenhong Zhou, Fengting Liang, Xiao Yang, Shicheng Fan, Jian-hong Fang, Peng Chen, Huichang Bi,
2025, 15(3):1430-1446. DOI:10.1016/j.apsb.2025.01.024
Abstract
A synthetic peptide, derived from neurotoxin GsMTx4, acts as a non-opioid analgesic to alleviate mechanical and neuropathic pain through the TRPV4 channel
ShaoXi Ke, Ping Dong, Yi Mei, JiaQi Wang, Mingxi Tang, Wanxin Su, JingJing Wang, Chen Chen, Xiaohui Wang, JunWei Ji, XinRan Zhuang, ShuangShuang Yang, Yun Zhang, Linda M. Boland, Meng Cui, Masahiro Sokabe, Zhe Zhang, QiongYao Tang,
2025, 15(3):1447-1462. DOI:10.1016/j.apsb.2024.12.028
Abstract
Novel carbazole attenuates vascular remodeling through STAT3/CIAPIN1 signaling in vascular smooth muscle cells
Joo-Hui Han, Jong-Beom Heo, Hyung-Won Lee, Min-Ho Park, Jangmi Choi, Eun Joo Yun, Seongpyo Lee, Gyu Yong Song, Chang-Seon Myung,
2025, 15(3):1463-1479. DOI:10.1016/j.apsb.2024.12.035
Abstract
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4
Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu,
2025, 15(3):1480-1496. DOI:10.1016/j.apsb.2024.12.031
Abstract
Ginsenoside CK targets PHD2 to prevent platelet adhesion and enhance blood circulation by modifying the three-dimensional arrangement of collagen
Chuanjing Cheng, Kaixin Liu, Jinling Zhang, Yanqi Han, Tiejun Zhang, Yuanyuan Hou, Gang Bai,
2025, 15(3):1497-1513. DOI:10.1016/j.apsb.2024.12.038
Abstract
Dihydromyricetin mitigates abdominal aortic aneurysm via transcriptional and post-transcriptional regulation of heme oxygenase-1 in vascular smooth muscle cells
Weile Ye, Pinglian Yang, Mei Jin, Jiami Zou, Zhihua Zheng, Yuanyuan Li, Dongmei Zhang, Wencai Ye, Zunnan Huang, Jiaojiao Wang, Zhiping Liu,
2025, 15(3):1514-1534. DOI:10.1016/j.apsb.2025.02.003
Abstract
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation
Chengfei Zhang, Ping Xu, Yongsheng Wang, Xin Chen, Yue Pan, Zhijie Ma, Cheng Wang, Haojun Xu, Guoren Zhou, Feng Zhu, Hongping Xia,
2025, 15(3):1535-1551. DOI:10.1016/j.apsb.2024.12.034
Abstract
BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progression
Haisheng Zhang, Linlin Lu, Cheng Yi, Tao Jiang, Yunqing Lu, Xianyuan Yang, Ke Zhong, Jiawang Zhou, Jiexin Li, Guoyou Xie, Zhuojia Chen, Zongpei Jiang, Gholamreza Asadikaram, Yanxi Peng, Dan Zhou, Hongsheng Wang,
2025, 15(3):1552-1570. DOI:10.1016/j.apsb.2024.12.037
Abstract
eIF3a function in immunity and protection against severe sepsis by regulating B cell quantity and function through m6A modification
Qianying Ouyang, Jiajia Cui, Yang Wang, Ke Liu, Yan Zhan, Wei Zhuo, Juan Chen, Honghao Zhou, Chenhui Luo, Jianming Xia, Liansheng Wang, Chengxian Guo, Jianting Zhang, Zhaoqian Liu, Jiye Yin,
2025, 15(3):1571-1588. DOI:10.1016/j.apsb.2025.02.005
Abstract
Parkin inhibits iron overload-induced cardiomyocyte ferroptosis by ubiquitinating ACSL4 and modulating PUFA-phospholipids metabolism
Dandan Xiao, Wenguang Chang, Xiang Ao, Lin Ye, Weiwei Wu, Lin Song, Xiaosu Yuan, Luxin Feng, Peiyan Wang, Yu Wang, Yi Jia, Xiaopeng Tang, Jianxun Wang,
2025, 15(3):1589-1607. DOI:10.1016/j.apsb.2024.12.027
Abstract
CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer
Yuncheng Bei, Sijie Wang, Rui Wang, Owais Ahmad, Meng Jia, Pengju Yao, Jianguo Ji, Pingping Shen,
2025, 15(3):1608-1625. DOI:10.1016/j.apsb.2024.12.019
Abstract
Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis
Wenxiang Hong, Hongbo Ma, Zhaoxu Yang, Jiaying Wang, Bowen Peng, Longling Wang, Yiwen Du, Lijun Yang, Lijiang Zhang, Zhibin Li, Han Huang, Difeng Zhu, Bo Yang, Qiaojun He, Jiajia Wang, Qinjie Weng,
2025, 15(3):1626-1642. DOI:10.1016/j.apsb.2025.02.004
Abstract
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3
Yanghao Chen, Bozhi Ye, Diyun Xu, Wante Lin, Zimin Fang, Xuefeng Qu, Xue Han, Wu Luo, Chen Chen, Weijian Huang, Hao Zhou, Gaojun Wu, Yi Wang, Guang Liang,
2025, 15(3):1643-1658. DOI:10.1016/j.apsb.2024.12.033
Abstract
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
Yuheng Jin, Xuxin Qi, Xiaoli Yu, Xirui Cheng, Boya Chen, Mingfei Wu, Jingyu Zhang, Hao Yin, Yang Lu, Yihui Zhou, Ao Pang, Yushen Lin, Li Jiang, Qiuqiu Shi, Shuangshuang Geng, Yubo Zhou, Xiaojun Yao, Linjie Li, Haiting Duan, Jinxin Che, Ji Cao, Qiaojun He, Xiaowu Dong,
2025, 15(3):1659-1679. DOI:10.1016/j.apsb.2025.01.021
Abstract
Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation
Taotao Lu, Hongguang Han, Chaohui Wu, Qian Li, Hongyan Hu, Wenwen Liu, Donglei Shi, Feifei Chen, Lefu Lan, Jian Li, Shihao Song, Baoli Li,
2025, 15(3):1680-1695. DOI:10.1016/j.apsb.2025.01.022
Abstract
Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence
Jiaqing Yang, Junhao Xu, Ziheng Qiu, Zhiyong Mao, Xiaojun Xu, Ying Jiang, Guizhu Wu,
2025, 15(3):1696-1699. DOI:10.1016/j.apsb.2025.01.026
Abstract
Monocytes in the brain—heart crosstalk control sleep under myocardial infarction
Meng Mao, Hailong Bing, Jianping Ye, Zhengyuan Xia, Qinjun Chu,
2025, 15(3):1700-1702. DOI:10.1016/j.apsb.2025.01.025
Abstract
Engineered bacteria assist CAR-cell immunotherapy
Tianyu Shao, Manman Xu, Jie Li, Xiao Zhao,
2025, 15(3):1703-1705. DOI:10.1016/j.apsb.2025.01.020
Abstract
Silencing excessive stress response of neurons— a new approach to treat neurodegeneration diseases
Chunyang Li, Hongkai Lian, Xiwen Ma, Jianping Ye,
2025, 15(3):1706-1708. DOI:10.1016/j.apsb.2024.11.013
Abstract
Liquid—liquid phase separation-assembled coacervate vesicles for biopharmaceutical delivery
Zao Ji, Jianbin Bi, Hong-Xu Liu, Heran Li,
2025, 15(3):1709-1711. DOI:10.1016/j.apsb.2025.01.019
Abstract
Evaluation of the efficacy and mechanisms of azvudine in elderly patients with malignant tumors complicated by COVID-19
Ranran Sun, Yihang Song, Zhe Li, Daming Wang, Zujiang Yu,
2025, 15(3):1712-1714. DOI:10.1016/j.apsb.2025.03.036
Abstract
Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights
Wenchao Wei, Bernd Schnabl,
2025, 15(3):1715-1716. DOI:10.1016/j.apsb.2025.01.016
Abstract
Erratum to “Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism” [Acta Pharm Sin B 14 (2024) 4883-4898]
Pengcheng Wang, Song-Yang Zhang, YongQiang Dong, Guangyi Zeng, Huiying Liu, Xian Wang, Changtao Jiang, Yin Li,
2025, 15(3):1717-1718. DOI:10.1016/j.apsb.2024.12.022
Abstract
Author correction to “Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice” [Acta Pharm Sin B 11 (2021) 1200-1212]
Yuyu Zhu, Ning Wan, Xinni Shan, Guoliang Deng, Qiang Xu, Hui Ye, Yang Sun,
2025, 15(3):1719-1720. DOI:10.1016/j.apsb.2024.12.009
Abstract
Author correction to “Up-regulation of glyclipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication” [Acta Pharm Sin B 9 (2019) 769-781]
Menghao Huang, Hu Li, Rong Xue, Jianrui Li, Lihua Wang, Junjun Cheng, Zhouyi Wu, Wenjing Li, Jinhua Chen, Xiaoqin Lv, Qiang Li, Pei Lan, Limin Zhao, Yongfeng Yang, Zonggen Peng, Jiandong Jiang,
2025, 15(3):1721-1721. DOI:10.1016/j.apsb.2024.12.001
Abstract

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