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Overview of host-directed antiviral targets for future research and drug development
Xiaoxia Gu, Mengzhu Zheng, Ya Gao, Shuang Lin, Xiaotian Zhang, Chunmei Chen, Hucheng Zhu, Weiguang Sun, Yonghui Zhang,
2025, 15(4):1723-1751. DOI:10.1016/j.apsb.2025.03.011
Abstract
Advances in development of antiviral strategies against respiratory syncytial virus
Ge Yang, Guangyu Jiang, Jiandong Jiang, Yuhuan Li,
2025, 15(4):1752-1772. DOI:10.1016/j.apsb.2025.02.015
Abstract
Post-translational modifications of collagen and its related diseases in metabolic pathways
Linghong Guo, Weiyi Xiang, Zhaoping Pan, He Gu, Xian Jiang,
2025, 15(4):1773-1795. DOI:10.1016/j.apsb.2025.02.007
Abstract
Polysaccharide nanoparticles as potential immune adjuvants: Mechanism and function
Yuhong Jiang, Shanshan Qi, Canquan Mao,
2025, 15(4):1796-1815. DOI:10.1016/j.apsb.2025.03.006
Abstract
Bacterial extracellular vesicles for gut microbiome-host communication and drug development
Dingfei Qian, Peijun Xu, Xinwei Wang, Chong Du, Xiao Zhao, Jiaqi Xu,
2025, 15(4):1816-1840. DOI:10.1016/j.apsb.2025.03.008
Abstract
Nano-drug delivery strategies affecting cancer-associated fibroblasts to reduce tumor metastasis
Linghui Zou, Peng Xian, Qing Pu, Yangjie Song, Shuting Ni, Lei Chen, Kaili Hu,
2025, 15(4):1841-1868. DOI:10.1016/j.apsb.2025.02.040
Abstract
Bioactive metallic nanoparticles for synergistic cancer immunotherapy
Lulu Wang, Demin Lin, Muqing Li, Yu Jiang, Yanfang Yang, Hongliang Wang, Hongqian Chu, Jun Ye, Yuling Liu,
2025, 15(4):1869-1911. DOI:10.1016/j.apsb.2025.02.022
Abstract
Construction and application of a large capacity VNAR library from the whitespotted bamboo shark (Chiloscyllium playgiosum)
Hao Li, Litong Liu, Xinyi Kang, Chuan-Wei Chen, Mengran Wang, Shaoqin Fu, Qingtong Zhou, Bo Zhao, Dehua Yang, Ming-Wei Wang,
2025, 15(4):1912-1921. DOI:10.1016/j.apsb.2025.02.012
Abstract
Identification of a JAK-STAT-miR155HG positive feedback loop in regulating natural killer (NK) cells proliferation and effector functions
Songyang Li, Yongjie Liu, Xiaofeng Yin, Yao Yang, Xinjia Liu, Jiaxing Qiu, Qinglan Yang, Yana Li, Zhiguo Tan, Hongyan Peng, Peiwen Xiong, Shuting Wu, Lanlan Huang, Xiangyu Wang, Sulai Liu, Yuxing Gong, Yuan Gao, Lingling Zhang, Junping Wang, Yafei Deng, Zhaoyang Zhong, Youcai Deng,
2025, 15(4):1922-1937. DOI:10.1016/j.apsb.2025.02.034
Abstract
CDK1-mediated phosphorylation of USP37 regulates SND1 stability and promotes oncogenesis in colorectal cancer
Liang Wu, Can Cheng, Ning Zhao, Liang Zhu, Heng Li, Jingwen Liu, Yang Wu, Xi Chen, Hanhui Yao, Lianxin Liu,
2025, 15(4):1938-1955. DOI:10.1016/j.apsb.2025.02.014
Abstract
GRK2 activates TRAF2-NF-κB signalling to promote hyperproliferation of fibroblast-like synoviocytes in rheumatoid arthritis
Chenchen Han, Liping Jiang, Weikang Wang, Shujun Zuo, Jintao Gu, Luying Chen, Zhuo Chen, Jiajie Kuai, Xuezhi Yang, Liang Xu, Yang Ma, Wei Wei,
2025, 15(4):1956-1973. DOI:10.1016/j.apsb.2025.02.031
Abstract
Obesity-driven oleoylcarnitine accumulation in tumor microenvironment promotes breast cancer metastasis-like phenotype
Chao Chen, Hongxia Zhang, Lingling Qi, Haoqi Lei, Xuefei Feng, Yingjie Chen, Yuanyuan Cheng, Defeng Pang, Jufeng Wan, Haiying Xu, Shifeng Cao, Baofeng Yang, Yan Zhang, Xin Zhao,
2025, 15(4):1974-1990. DOI:10.1016/j.apsb.2025.02.026
Abstract
SAE1 promotes tumor cell malignancy via SUMOylation and liquid-liquid phase separation facilitated nuclear export of p27
Ling Wang, Jie Min, Jinjun Qian, Xiaofang Huang, Xichao Yu, Yuhao Cao, Shanliang Sun, Mengying Ke, Xinyu Lv, Wenfeng Su, Mengjie Guo, Nianguang Li, Shiqian Qi, Hongming Huang, Chunyan Gu, Ye Yang,
2025, 15(4):1991-2007. DOI:10.1016/j.apsb.2025.02.011
Abstract
Thermal proteome profiling (TPP) reveals NAMPT as the anti-glioma target of phenanthroindolizidine alkaloid PF403
Fangfei Li, Zhaoxin Zhang, Qinyan Shi, Rubing Wang, Ming Ji, Xiaoguang Chen, Yong Li, Yunbao Liu, Shishan Yu,
2025, 15(4):2008-2023. DOI:10.1016/j.apsb.2025.02.027
Abstract
Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways
Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang,
2025, 15(4):2024-2038. DOI:10.1016/j.apsb.2025.02.029
Abstract
p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization
Li Qiu, Wenfang Li, Lei Zhang, Xia Zhang, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim,
2025, 15(4):2039-2058. DOI:10.1016/j.apsb.2025.02.013
Abstract
Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk
Chuan Ding, Zeping Wang, Kao Shi, Sunan Li, Xinyue Dou, Yan Ning, Gang Cheng, Qiao Yang, Xianan Sang, Mengyun Peng, Qiang Lyu, Lu Wang, Xin Han, Gang Cao,
2025, 15(4):2059-2076. DOI:10.1016/j.apsb.2025.02.017
Abstract
Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2
Kexin Jia, Yinhao Zhang, Fanghong Li, Runping Liu, Jianzhi Wu, Jiaorong Qu, Ranyi Luo, Zixi Huang, Zhe Xu, Xiaojiaoyang Li,
2025, 15(4):2077-2094. DOI:10.1016/j.apsb.2025.03.002
Abstract
Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
Dan Feng, Jian Zhang, Huanmin Niu, Xiaoxue Zheng, Mengqi Jia, Qiqi Lu, Jing Wang, Wenxue Guo, Qi Sun, Huiqing Yuan, Hongxiang Lou,
2025, 15(4):2095-2113. DOI:10.1016/j.apsb.2025.02.023
Abstract
Design, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages
Eline Geervliet, Sahil Arora, Dagmara Donohue, Carlos Antonio de Albuquerque Pinheiro, Leon W. M. M. Terstappen, Richard Schasfoort, Julieta Paez, Raj Kumar, Ruchi Bansal,
2025, 15(4):2114-2133. DOI:10.1016/j.apsb.2025.02.018
Abstract
Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimer's disease
Zhipei Sang, Shuheng Huang, Wanying Tan, Yujuan Ban, Keren Wang, Yufan Fan, Hongsong Chen, Qiyao Zhang, Chanchan Liang, Jing Mi, Yunqi Gao, Ya Zhang, Wenmin Liu, Jianta Wang, Wu Dong, Zhenghuai Tan, Lei Tang, Haibin Luo,
2025, 15(4):2134-2155. DOI:10.1016/j.apsb.2025.02.030
Abstract
GPC3-mediated lysosome-targeting chimeras (GLTACs) for targeted degradation of membrane proteins
Yuxin Fang, Yaojin Zhu, Wei Wang, Zhewei Xia, Shipeng He, Guoqiang Dong, Chunquan Sheng,
2025, 15(4):2156-2169. DOI:10.1016/j.apsb.2025.02.037
Abstract
Discovery and mechanism verification of first-in-class hydrophobic tagging-based degraders of HBV core protein
Shujing Xu, Ya Wang, Dazhou Shi, Shuo Wang, Lijun Qiao, Ge Yang, Yang Zhou, Xinyong Liu, Shuo Wu, Yuhuan Li, Peng Zhan,
2025, 15(4):2170-2196. DOI:10.1016/j.apsb.2025.02.033
Abstract
Microneedle delivery platform integrated with Staphylococcus epidermidis-derived extracellular vesicles-based nanoantibiotics for efficient bacterial infection atopic dermatitis treatment
Hong Zhou, Shuting Zhang, Xinxin Liu, Aiping Feng, Siyuan Chen, Wei Liu,
2025, 15(4):2197-2216. DOI:10.1016/j.apsb.2025.02.038
Abstract
Intranodal injection of neoantigen-bearing engineered Lactococcus lactis triggers epitope spreading and systemic tumor regressions
Junmeng Zhu, Yi Sun, Xiaoping Qian, Lin Li, Fangcen Liu, Xiaonan Wang, Yaohua Ke, Jie Shao, Lijing Zhu, Lifeng Wang, Qin Liu, Baorui Liu,
2025, 15(4):2217-2236. DOI:10.1016/j.apsb.2025.02.041
Abstract
siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy
Yunfei Yi, Zhangwen Peng, Yuanqi Liu, Huisong Hao, Liu Yu, Simin Wen, Shengjie Sun, Jianlin Shi, Meiying Wu, Lin Mei,
2025, 15(4):2237-2252. DOI:10.1016/j.apsb.2025.02.020
Abstract
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways
Jiapeng Yang, Qiqian Xue, Chao Li, Yingying Jin, Qingyun Xue, Wei Liu, Zhitao Niu, Xiaoyu Ding,
2025, 15(4):2253-2272. DOI:10.1016/j.apsb.2025.03.005
Abstract
Amyloid-like fibrils derived from β-sheets of gp120 contribute to the neuronal pathology of HIV-associated neurocognitive disorders
Chan Yang, Ruyu Wang, Chen Cheng, Jiaqi Yu, Kunyu Lu, Haobin Li, Jinshen Wang, Guodong Hu, Hao Yang, Jianfu He, Hao Su, Qingping Zhan, Suiyi Tan, Tong Zhang, Shuwen Liu,
2025, 15(4):2273-2277. DOI:10.1016/j.apsb.2025.02.024
Abstract
Optimizing TPD-based oncology drug development: the critical role of PDR distribution in POI-positive cancer cells
Xinyi Tao, Li Zou, Wenxin Fang, Ruolan Zhang, Jianhui Liang, Yan Wang, Lei Chen,
2025, 15(4):2278-2282. DOI:10.1016/j.apsb.2025.02.016
Abstract
Feature-based molecular networking (FBMN): An efficient booster for discovering novel natural products or metabolites
Meiru Han, Huan Xia, Guiyang Xia, Xiaohong Wei, Jinyu Li, Yuzhuo Wu, Sheng Lin,
2025, 15(4):2283-2286. DOI:10.1016/j.apsb.2025.02.019
Abstract
Synovial joints: The barometer of systemic inflammation
Jie Pan, Qianqian Liu, Yang Sun,
2025, 15(4):2287-2289. DOI:10.1016/j.apsb.2024.12.025
Abstract
Multi region dissection of Alzheimer's brain at single cell level
Meng Mao, Chengming Wang, Xiwen Ma, Jianping Ye,
2025, 15(4):2290-2292. DOI:10.1016/j.apsb.2024.12.010
Abstract
Leveraging glypican-3 (GPC3)-mediated lysosome-targeting chimeras (GLTACs) for targeted membrane protein degradation
Bin Yu,
2025, 15(4):2293-2294. DOI:10.1016/j.apsb.2025.03.044
Abstract
PTM-centered therapy in malignant tumors: A new story of colchicine
Min Huang,
2025, 15(4):2295-2296. DOI:10.1016/j.apsb.2025.03.045
Abstract
Author correction to “PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism” [Acta Pharm Sin B 13 (2023) 157-173]
Mingming Sun, Leilei Li, Yujia Niu, Yingzhi Wang, Qi Yan, Fei Xie, Yaya Qiao, Jiaqi Song, Huanran Sun, Zhen Li, Sizhen Lai, Hongkai Chang, Han Zhang, Jiyan Wang, Chenxin Yang, Huifang Zhao, Junzhen Tan, Yanping Li, Shuangping Liu, Bin Lu, Min Liu, Guangyao Kong, Yujun Zhao, Chunze Zhang, Shu-Hai Lin, Cheng Luo, Shuai Zhang, Changliang Shan,
2025, 15(4):2297-2299. DOI:10.1016/j.apsb.2025.02.006
Abstract
Author correction to “The neuroprotective effect of traditional Chinese medicinal plants—A critical review” [Acta Pharm Sin B 13 (2023) 3208-3237]
João Moreira, Mariana Machado, Mónica Dias-Teixeira, Ricardo Ferraz, Cristina Delerue-Matos, Clara Grosso,
2025, 15(4):2300-2300. DOI:10.1016/j.apsb.2024.12.002
Abstract