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RNA splicing: Novel star in pulmonary diseases with a treatment perspective
Zhihui Niu, Bingqian Xu, Wei Li, Jian Sun, Haihai Liang,
2025, 15(5):2301-2322. DOI:10.1016/j.apsb.2025.03.023
Abstract
The neuroscience of cancer: Focus on neuropeptidergic systems
Zikai Dong, Yongfei Wang, Weilin Jin,
2025, 15(5):2323-2350. DOI:10.1016/j.apsb.2025.03.025
Abstract
Modulating inflammatory prostaglandin E2 signaling to mitigate neurobehavioral comorbidities associated with seizure disorders
Chenyao Jiang, Ying Yu, Jiawang Liu, Jianxiong Jiang,
2025, 15(5):2351-2362. DOI:10.1016/j.apsb.2025.03.024
Abstract
“Weibing” in traditional Chinese medicine—biological basis and mathematical representation of disease-susceptible state
Wanyang Sun, Rong Wang, Shuhua Ouyang, Wanli Liang, Junwei Duan, Wenyong Gong, Lianting Hu, Xiujuan Chen, Yifang Li, Hiroshi Kurihara, Xinsheng Yao, Hao Gao, Rongrong He,
2025, 15(5):2363-2371. DOI:10.1016/j.apsb.2025.03.009
Abstract
Precise nanoscale fabrication technologies, the “last mile” of medicinal development
Ye Bi, Sensen Xie, Ziwei Li, Shiyan Dong, Lesheng Teng,
2025, 15(5):2372-2401. DOI:10.1016/j.apsb.2025.03.040
Abstract
Inhaled non-viral delivery systems for RNA therapeutics
Cheng Huang, Hongjian Li, Xing Duan, Peidong Zhang, Shaolong Qi, Jianshi Du, Xiangrong Song, Aiping Tong, Guocan Yu,
2025, 15(5):2402-2430. DOI:10.1016/j.apsb.2025.03.033
Abstract
Modified probiotics and the related combinatorial therapeutics
Luo Zhao, Mengya Niu, Zilin Ma, Fengyun He, Xinxin Liu, Xunwei Gong, Zhanfei Chai, Ziqing Wang, Qianhua Feng, Lei Wang,
2025, 15(5):2431-2453. DOI:10.1016/j.apsb.2025.03.021
Abstract
VenusMutHub: A systematic evaluation of protein mutation effect predictors on small-scale experimental data
Liang Zhang, Hua Pang, Chenghao Zhang, Song Li, Yang Tan, Fan Jiang, Mingchen Li, Yuanxi Yu, Ziyi Zhou, Banghao Wu, Bingxin Zhou, Hao Liu, Pan Tan, Liang Hong,
2025, 15(5):2454-2467. DOI:10.1016/j.apsb.2025.03.028
Abstract
Structural insights into the binding modes of lanreotide and pasireotide with somatostatin receptor 1
Zicheng Zeng, Qiwen Liao, Shiyi Gan, Xinyu Li, Tiantian Xiong, Lezhi Xu, Dan Li, Yunlu Jiang, Jing Chen, Richard Ye, Yang Du, Thiansze Wong,
2025, 15(5):2468-2479. DOI:10.1016/j.apsb.2025.03.043
Abstract
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer
Yujie Zhang, Weiyi Zhao, Ling Wu, Tianjing Ai, Jie He, Zetao Chen, Chuangyuan Wang, Hui Wang, Rui Zhou, Chaoqun Liu, Liang Zhao,
2025, 15(5):2480-2497. DOI:10.1016/j.apsb.2025.03.026
Abstract
Anti-SARS-CoV-2 prodrug ATV006 has broad-spectrum antiviral activity against human and animal coronaviruses
Tiefeng Xu, Kun Li, Siyao Huang, Konstantin I. Ivanov, Sidi Yang, Yanxi Ji, Hanwei Zhang, Wenbin Wu, Ye He, Qiang Zeng, Feng Cong, Qifan Zhou, Yingjun Li, Jian Pan, Jincun Zhao, Chunmei Li, Xumu Zhang, Liu Cao, Deyin Guo,
2025, 15(5):2498-2510. DOI:10.1016/j.apsb.2025.02.028
Abstract
A critical role for Phocaeicola vulgatus in negatively impacting metformin response in diabetes
Manyun Chen, Yilei Peng, Yuhui Hu, Zhiqiang Kang, Ting Chen, Yulong Zhang, Xiaoping Chen, Qing Li, Zuyi Yuan, Yue Wu, Heng Xu, Gan Zhou, Tao Liu, Honghao Zhou, Chunsu Yuan, Weihua Huang, Wei Zhang,
2025, 15(5):2511-2528. DOI:10.1016/j.apsb.2025.02.008
Abstract
Targeting the JAK2-STAT3-UCHL3-ENO1 axis suppresses glycolysis and enhances the sensitivity to 5-FU chemotherapy in TP53-mutant colorectal cancer
Haisong Xin, Zitong Zhao, Shichao Guo, Ruoxi Tian, Liying Ma, Yang Yang, Lianmei Zhao, Guanglin Wang, Baokun Li, Xuhua Hu, Yongmei Song, Guiying Wang,
2025, 15(5):2529-2544. DOI:10.1016/j.apsb.2025.03.041
Abstract
Deubiquitinase USP13 alleviates doxorubicin-induced cardiotoxicity through promoting the autophagy-mediated degradation of STING
Liming Lin, Jibo Han, Diyun Xu, Zimin Fang, Bozhi Ye, Jinfu Qian, Xue Han, Julian Min, Xiaohong Long, Gaojun Wu, Guang Liang,
2025, 15(5):2545-2558. DOI:10.1016/j.apsb.2025.03.051
Abstract
CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers
Liuhai Zheng, Youbing Ding, Xiaolong Xu, Huifang Wang, Guangwei Shi, Yang Li, Yuanqiao He, Yue Gong, Xiaodong Zhang, Jinxi Wei, Zhiyu Dong, Jiexuan Li, Shanchao Zhao, Rui Hou, Wei Zhang, Jigang Wang, Zhijie Li,
2025, 15(5):2559-2574. DOI:10.1016/j.apsb.2025.03.039
Abstract
NAT10 inhibition alleviates astrocyte autophagy by impeding ac4C acetylation of Timp1 mRNA in ischemic stroke
Li Yang, Xiaotong Li, Yaxuan Zhao, Hao Chen, Can Wang, Angrong Wu, Xintong Guo, Yue Huang, Qihui Wang, Lingyun Hao, Xiaowen Li, Ying Ji, Jin Ban, Guangtian Wang, Junli Cao, Zhiqiang Pan,
2025, 15(5):2575-2592. DOI:10.1016/j.apsb.2025.03.042
Abstract
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells
Yang Ou, Kun Zhang, Qiuying Shuai, Chenyang Wang, Huayu Hu, Lixia Cao, Chunchun Qi, Min Guo, Zhaoxian Li, Jie Shi, Yuxin Liu, Siyu Zuo, Xiao Chen, Yanjing Wang, Mengdan Feng, Hang Wang, Peiqing Sun, Yi Shi, Guang Yang, Shuang Yang,
2025, 15(5):2593-2611. DOI:10.1016/j.apsb.2025.03.004
Abstract
First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy-lysosome pathway
Ye Zhong, Jing Xu, Huiying Cao, Jie Gao, Shaoyue Ding, Zhaohui Ren, Huali Yang, Yili Sun, Maosheng Cheng, Jia Li, Yang Liu,
2025, 15(5):2612-2624. DOI:10.1016/j.apsb.2025.03.047
Abstract
A proximity-induced chimera platform for targeted protein arginine methylation
Yanlin Jian, Tianyang Zhou, Chendong Guo, Yibo Gao, Chen Yao, Zixi Wang, Xuehan Jiang, Ke Wang, Jian Ma, Yang Gao, Yizeng Fan, Jing Liu, Bohan Ma, Lei Li,
2025, 15(5):2625-2639. DOI:10.1016/j.apsb.2025.03.049
Abstract
Targeting copper homeostasis: Akkermansia-derived OMVs co-deliver Atox1 siRNA and elesclomol for cancer therapy
Muhammad Hamza, Shuai Wang, Hao Wu, Jiayi Sun, Yang Du, Chuting Zeng, Yike Liu, Kun Li, Xili Zhu, Huiying Liu, Lin Chen, Motao Zhu,
2025, 15(5):2640-2654. DOI:10.1016/j.apsb.2025.03.014
Abstract
Metabolic reprogramming nanomedicine potentiates colon cancer sonodynamic immunotherapy by inhibiting the CD39/CD73/ADO pathway
Yuanyuan Zhang, Weiwei Jin, Zhichao Deng, Bowen Gao, Yuanyuan Zhu, Junlong Fu, Chenxi Xu, Wenlong Wang, Ting Bai, Lianying Jiao, Hao Wu, Mingxin Zhang, Mingzhen Zhang,
2025, 15(5):2655-2672. DOI:10.1016/j.apsb.2025.03.046
Abstract
Sulfafurazole dimers potentiate chemo-immunotherapy of low immunogenic breast cancer by preventing the PD-L1 exosomes secretion
Zheng Wang, Ronghui Yin, Lin Zhang, Shiyu Li, Zhanwei Zhou, Minjie Sun,
2025, 15(5):2673-2686. DOI:10.1016/j.apsb.2025.03.007
Abstract
Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma
Hongyan Zhang, Jingyi Huang, Yujie Li, Wanyu Jin, Jiale Wei, Ninghui Ma, Limei Shen, Mancang Gu, Chaofeng Mu, Donghang Xu, Yang Xiong,
2025, 15(5):2687-2702. DOI:10.1016/j.apsb.2025.03.017
Abstract
A cisplatin prodrug-based self-assembling ozone delivery nanosystem sensitizes radiotherapy in triple-negative breast cancer
Tianyue Xu, Dan Zheng, Meixu Chen, Linlin Song, Zhihui Liu, Yan Cheng, Yujie Zhao, Liwen Huang, Yixuan Li, Zhankun Yang, Cong Li, Biao Dong, Jing Jing, Hubing Shi,
2025, 15(5):2703-2722. DOI:10.1016/j.apsb.2025.03.020
Abstract
Phenotypic plasticity and secretory heterogeneity in subpopulations derived from single cancer cell
Zhun Lin, Siping Liang, Zhe Pu, Zhengyu Zou, Luxuan He, Christopher J. Lyon, Yuanqing Zhang, Tony Y. Hu, Minhao Wu,
2025, 15(5):2723-2735. DOI:10.1016/j.apsb.2025.02.039
Abstract
Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure
Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier,
2025, 15(5):2736-2745. DOI:10.1016/j.apsb.2025.03.030
Abstract
Prodrug-based combinational nanomedicine remodels lipid metabolism for reinforced ferroptosis and immune activation
Ling Lin, Zaixiang Fang, Guohao Liu, Yiwei Liu, Zhiqian Li, Dayi Pan, Yunkun Li, Hemi Kang, Xiaoding Shen, Jingyao Zhang, Qiyong Gong, Kui Luo, Jing Jing,
2025, 15(5):2746-2763. DOI:10.1016/j.apsb.2025.03.016
Abstract
Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids
Shang Chen, Dong Liu, Liyang Wang, Aili Fan, Mengyue Wu, Ning Xu, Kui Zhu, Wenhan Lin,
2025, 15(5):2764-2777. DOI:10.1016/j.apsb.2025.02.036
Abstract
Design and functional characterization of a tetravalent NK cell-engaging bispecific antibody with enhanced half-life for CD30+ lymphoma
Caizhi Zhao, Liping Xie, Ming-Wei Wang, Youjia Hu,
2025, 15(5):2778-2782. DOI:10.1016/j.apsb.2025.03.012
Abstract
Targeting stiff stroma by neutralizing LOX-mediated matrix crosslinking in pancreatic cancer
Shan Zhang, Zhiwei Cai, Luju Jiang, Shuqi Cai, Zheqi Weng, Shuheng Jiang,
2025, 15(5):2783-2786. DOI:10.1016/j.apsb.2025.03.010
Abstract
SMAD4 depletion enhances NHEJ by regulating BRCA1 expression through ARIH1 in pancreatic cancer
Yiran Song, Yazhi He, Tianyu Yu, Yang Wang, Liwei An, Yang Shi, Yingqun Zhou, Junyi Ju, Feng Wang,
2025, 15(5):2787-2790. DOI:10.1016/j.apsb.2025.03.035
Abstract
Extrachromosomal DNA as a carrier of extra copies of oncogenes for heterogeneity and malignancy of glioma
Lin-jian Wang, Jianping Ye,
2025, 15(5):2791-2794. DOI:10.1016/j.apsb.2025.02.001
Abstract
Skin as an autonomous immune organ: Antibody production and host protection
Wende Deng, Ting Li,
2025, 15(5):2795-2797. DOI:10.1016/j.apsb.2025.03.027
Abstract
TRIM21-based degradation strategy for multimeric proteins
Wei Wang, Chunquan Sheng,
2025, 15(5):2798-2800. DOI:10.1016/j.apsb.2025.02.025
Abstract
Editorial of virtual special issue: The development of antiviral drug discovery
Shaoqing Du, Xueping Hu, Xinyong Liu, Peng Zhan,
2025, 15(5):2801-2804. DOI:10.1016/j.apsb.2025.03.013
Abstract
VenusMutHub—A benchmark for protein mutation effect prediction
Junlin Yu, Guobo Li,
2025, 15(5):2805-2807. DOI:10.1016/j.apsb.2025.05.001
Abstract
Innovative discovery and mechanistic validation of HyT-PD ligands for selective CDK9-targeted protein degradation
Yizhan Zhai, Jianfeng Cai,
2025, 15(5):2808-2809. DOI:10.1016/j.apsb.2025.04.023
Abstract
Author correction to “SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade” [Acta Pharm Sin B 9 (2019) 304-315]
Mingxia Zhao, Wenjie Guo, Yuanyuan Wu, Chenxi Yang, Liang Zhong, Guoliang Deng, Yuyu Zhu, Wen Liu, Yanhong Gu, Yin Lu, Lingdong Kong, Xiangbao Meng, Qiang Xu, Yang Sun,
2025, 15(5):2810-2812. DOI:10.1016/j.apsb.2024.12.023
Abstract
Author correction to “Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury” [Acta Pharm Sin B 12 (2022) 1885-1898]
Tengfei Xue, Juan Ji, Yuqin Sun, Xinxin Huang, Zhenyu Cai, Jin Yang, Wei Guo, Ruobing Guo, Hong Cheng, Xiulan Sun,
2025, 15(5):2813-2814. DOI:10.1016/j.apsb.2025.02.032
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica