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Editor Profiles: Guest Editors of Special Column on Nanomedicines for Tumor Microenvironment Modulation
2025, 15(6):2815-2815. DOI:10.1016/j.apsb.2025.05.026
Abstract
Editorial of the special column on nanomedicines for tumor microenvironment modulation
Huile Gao, Feihu Wang, Yang Shi,
2025, 15(6):2816-2817. DOI:10.1016/j.apsb.2025.05.027
Abstract
Advancements in CRISPR/Cas systems for disease treatment
Yangsong Xu, Hao Le, Qinjie Wu, Ning Wang, Changyang Gong,
2025, 15(6):2818-2844. DOI:10.1016/j.apsb.2025.05.007
Abstract
Nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy
Chenwei Jiang, Minglu Tang, Yun Su, Junjie Xie, Qi Shang, Mingmei Guo, Xiaoran An, Longfei Lin, Ruibin Wang, Qian Huang, Guangji Zhang, Hui Li, Feihu Wang,
2025, 15(6):2845-2866. DOI:10.1016/j.apsb.2025.04.002
Abstract
Self-degradable “gemini-like” ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases
Qiu Wang, Bin Wan, Yao Feng, Zimeng Yang, Dan Li, Fan Liu, Ya Gao, Chang Li, Yanhua Liu, Yongbing Sun, Zhonggui He, Cong Luo, Jin Sun, Qikun Jiang,
2025, 15(6):2867-2883. DOI:10.1016/j.apsb.2025.04.003
Abstract
Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged β-amyloid nanoscavenger for Alzheimer's disease therapy
Yanyan Xu, Xiangtong Ye, Yanfeng Du, Wenqin Yang, Fan Tong, Wei Li, Qianqian Huang, Yongke Chen, Hanmei Li, Huile Gao, Weiwei Zhang,
2025, 15(6):2884-2899. DOI:10.1016/j.apsb.2025.02.035
Abstract
Submicron-sized superantigen biomimetic liposomes with highly efficient pulmonary accumulation to remodel local immune microenvironment for cancer chemoimmunotherapy
Bochuan Yuan, Feng Zhang, Qiucheng Yan, Wanmei Wang, Zhangyu Li, Lina Du, Yiguang Jin, Fei Xie,
2025, 15(6):2900-2914. DOI:10.1016/j.apsb.2025.03.019
Abstract
Silencing PTPN2 with nanoparticle-delivered small interfering RNA remodels tumor microenvironment to sensitize immunotherapy in hepatocellular carcinoma
Fu Wang, Haoyu You, Huahua Liu, Zhuoran Qi, Xuan Shi, Zhiping Jin, Qingyang Zhong, Taotao Liu, Xizhong Shen, Sergii Rudiuk, Jimin Zhu, Tao Sun, Chen Jiang,
2025, 15(6):2915-2929. DOI:10.1016/j.apsb.2025.03.015
Abstract
Obesity-cancer axis crosstalk: Molecular insights and therapeutic approaches
Ahmed Rakib, Md Abdullah Al Mamun, Mousumi Mandal, Priti Sinha, Udai P. Singh,
2025, 15(6):2930-2944. DOI:10.1016/j.apsb.2025.04.029
Abstract
Linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions
Kishore Madamanchi, Jianhua Zhang, Girish C. Melkani,
2025, 15(6):2945-2965. DOI:10.1016/j.apsb.2025.04.011
Abstract
Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease
Zihan Wang, Kaige Zhang, Minghao Huang, Dehao Shang, Xiaomin He, Zhou Wu, Xu Yan, Xinwen Zhang,
2025, 15(6):2966-2984. DOI:10.1016/j.apsb.2025.04.019
Abstract
Unravelling the target landscape of tranylcypromines for new drug discovery
Yihui Song, Junbiao Chang, Bin Yu,
2025, 15(6):2985-3007. DOI:10.1016/j.apsb.2025.04.012
Abstract
Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia
Jingyu Wang, Xiangning Liu, Rongxin Zhu, Ying Sun, Boyang Jiao, Keyan Wang, Yong Jiang, Yong Wang, Chun Li, Wei Wang,
2025, 15(6):3008-3024. DOI:10.1016/j.apsb.2025.04.025
Abstract
Neurokinin 1 receptor inhibition alleviated mitochondrial dysfunction via restoring purine nucleotide cycle disorder driven by substance P in acute pancreatitis
Chenxia Han, Lu Li, Lin Bai, Yaling Wu, Jiawang Li, Yiqin Wang, Wanmeng Li, Xue Ren, Ping Liao, Xiaoting Chen, Yaguang Zhang, Fengzhi Wu, Feng Li, Dan Du, Qing Xia,
2025, 15(6):3025-3040. DOI:10.1016/j.apsb.2025.03.037
Abstract
SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts
Tongzhu Jin, Huiying Gao, Yuquan Wang, Zhiwei Ning, Danyang Bing, Yan Wang, Yi Chen, Xiaomu Tian, Qiudi Liu, Zhihui Niu, Jiayu Guo, Jian Sun, Ruoxuan Yang, Qianqian Wang, Shifen Li, Tianyu Li, Yuhong Zhou, Wenxin He, Yanjie Lu, Yunyan Gu, Haihai Liang,
2025, 15(6):3041-3058. DOI:10.1016/j.apsb.2025.04.017
Abstract
RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis
Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, Yilin Che, Junlin Chen, Wenhao Zhang, Chengjian He, Minghang Qi, Xiaohong Shu, Manman Tian, Xiangge Tian, Yan Tian, Sa Deng, Yan Wang, Xiaokui Huo, Zhenlong Yu, Xiaochi Ma,
2025, 15(6):3059-3072. DOI:10.1016/j.apsb.2025.03.048
Abstract
An anti-complement homogeneous polysaccharide from Houttuynia cordata ameliorates acute pneumonia with H1N1 and MRSA coinfection through rectifying Treg/Th17 imbalance in the gut-lung axis and NLRP3 inflammasome activation
Xinxing Li, Wenxin Ding, Yan Lu, Haiyan Zhu, Weilian Bao, Yang Liu, Jiaren Lyu, Lishuang Zhou, Hong Li, Jiyang Li, Daofeng Chen,
2025, 15(6):3073-3091. DOI:10.1016/j.apsb.2025.04.008
Abstract
ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells
Yuhua Deng, Zhiyan Chen, Peixian Chen, Yaming Xiong, Chuling Zhang, Qiuyuan Wu, Huiqi Huang, Shuqing Yang, Kun Zhang, Tiancheng He, Wei Li, Guolin Ye, Wei Luo, Hongsheng Wang, Dan Zhou,
2025, 15(6):3092-3106. DOI:10.1016/j.apsb.2025.04.018
Abstract
Ablation of macrophage transcriptional factor FoxO1 protects against ischemia-reperfusion injury-induced acute kidney injury
Yao He, Xue Yang, Chenyu Zhang, Min Deng, Bin Tu, Qian Liu, Jiaying Cai, Ying Zhang, Li Su, Zhiwen Yang, Hongfeng Xu, Zhongyuan Zheng, Qun Ma, Xi Wang, Xuejun Li, Linlin Li, Long Zhang, Yongzhuo Huang, Lu Tie,
2025, 15(6):3107-3124. DOI:10.1016/j.apsb.2025.04.009
Abstract
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition
Lei Wang, Shanchun Ge, Ye Zhang, Deqin Feng, Ting Zhu, Louqian Zhang, Chaofeng Zhang,
2025, 15(6):3125-3148. DOI:10.1016/j.apsb.2025.04.027
Abstract
Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis
Bin Liu, Wen-Zhe Deng, Wen-Hua Hu, Rong-Xi Lu, Qing-Yu Zhang, Chen-Feng Gao, Xiao-Jie Huang, Wei-Guo Liao, Jin Gao, Yang Liu, Hiroshi Kurihara, Yi-Fang Li, Xu-Hui Zhang, Yan-Ping Wu, Lei Liang, Rong-Rong He,
2025, 15(6):3149-3162. DOI:10.1016/j.apsb.2025.04.001
Abstract
Design, synthesis and biological evaluation of a novel class of indazole-containing compounds with potent anti-influenza activities targeting the PA-PB1 interface
Yun-Sang Tang, Chao Zhang, Jing Xu, Haibo Zhang, Zhe Jin, Mengjie Xiao, Nuermila Yiliyaer, Er-Fang Huang, Xin Zhao, Chun Hu, Pang-Chui Shaw,
2025, 15(6):3163-3180. DOI:10.1016/j.apsb.2025.04.014
Abstract
Discovery of papyifuran A as an unusual cembrane diterpenoid from Boswellia papyrifera resin reveals EEF2 as a potent new drug target for fibrosis of multiple organs
Madhu Babu Sura, Yeting Zhou, Jijun Li, Yongxian Cheng,
2025, 15(6):3181-3195. DOI:10.1016/j.apsb.2025.04.004
Abstract
Functional aptamer evolution-enabled elucidation of a melanoma migration-related bioactive epitope
Hong Xuan, Siqi Bian, Qinguo Liu, Jun Li, Shaojin Li, Sharpkate Shaker, Haiyan Cao, Tongxuan Wei, Panzhu Yao, Yifan Chen, Xiyang Liu, Ruidong Xue, Youbo Zhang, Liqin Zhang,
2025, 15(6):3196-3209. DOI:10.1016/j.apsb.2025.03.003
Abstract
Unveiling the metabolic fate of drugs through metabolic reaction-based molecular networking
Haodong Zhu, Xupeng Tong, Qi Wang, Aijing Li, Zubao Wu, Qiqi Wang, Pei Lin, Xinsheng Yao, Liufang Hu, Liangliang He, Zhihong Yao,
2025, 15(6):3210-3225. DOI:10.1016/j.apsb.2025.03.050
Abstract
Targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery
Siqi Wu, Qing Tang, Weifeng Fang, Zhe Sun, Meng Zhang, Ergang Liu, Yang Cao, Yongzhuo Huang,
2025, 15(6):3226-3242. DOI:10.1016/j.apsb.2025.04.006
Abstract
A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy
Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, Jinan Guo, Wei Huang, Jingbo Ma, Chunjin Fu, Da Yin, Guohua Zeng, Ying Long, Jigang Wang, Zhijie Li,
2025, 15(6):3243-3258. DOI:10.1016/j.apsb.2025.04.007
Abstract
Alginate lyase immobilized Chlamydomonas algae microrobots: minimally invasive therapy for biofilm penetration and eradication
Xiaoting Zhang, Huaan Li, Lu Liu, Yanzhen Song, Lishan Zhang, Jiajun Miao, Jiamiao Jiang, Hao Tian, Chang Liu, Fei Peng, Yingfeng Tu,
2025, 15(6):3259-3272. DOI:10.1016/j.apsb.2025.03.034
Abstract
A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment
Rui Liao, Yuequan Wang, Ziqi Lin, Yuting Wang, Hongyuan Zhang, Qin Chen, Shenwu Zhang, Jin Sun, Zhonggui He, Cong Luo,
2025, 15(6):3273-3290. DOI:10.1016/j.apsb.2025.03.029
Abstract
Tranexamic acid-fatty alcohol polyoxyethylene ether conjugation/PVA foam for venous sclerotherapy via vascular damage and inhibiting plasmin system
Jizhuang Ma, Keda Zhang, Wenhan Li, Yu Ding, Yongfeng Chen, Xiaoyu Huang, Tong Yu, Di Song, Haoran Niu, Huichao Xie, Tianzhi Yang, Xiaoyun Zhao, Xinggang Yang, Pingtian Ding,
2025, 15(6):3291-3304. DOI:10.1016/j.apsb.2025.03.032
Abstract
Pitavastatin-loaded procyanidins self-assembled nanoparticles alleviate advanced atherosclerosis via modulating macrophage efferocytosis and cholesterol efflux
Yizhou Wu, Hongyan Zhou, Hao Liu, Jiayao Hu, Yue Sun, Wei Yan, Chunyi Tong, Ying Kong, Bin Liu,
2025, 15(6):3305-3320. DOI:10.1016/j.apsb.2024.08.006
Abstract
Unveiling nonribosomal peptide synthetases from the ergot fungus Claviceps purpurea involved in the formation of diverse ergopeptines
Jing-Jing Chen, Ting Gong, Wei-Bo Wang, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu,
2025, 15(6):3321-3337. DOI:10.1016/j.apsb.2025.03.022
Abstract
Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota
Manjiong Wang, Xiaobo Guo, Hanfang Liu, Xiao Li, Yue Yao, Qing Fu, Yu Jin, Shuaishuai Ni, Xiaokang Li, Chaojiang Xiao, Bei Jiang, Conglong Xia, Jian Li, Yixiang Xu,
2025, 15(6):3338-3342. DOI:10.1016/j.apsb.2025.04.005
Abstract
PRIME, a temperature-guided language model revolutionizes protein engineering
Yuanxi Yu, Qianhui Wang, Yike Zou,
2025, 15(6):3343-3345. DOI:10.1016/j.apsb.2025.04.010
Abstract
Mechanism of Alzheimer's disease treatment by sound and light stimulation
Lixuan Ren, Xiwen Ma, Jianping Ye,
2025, 15(6):3346-3348. DOI:10.1016/j.apsb.2025.03.031
Abstract
Submicron-sized superantigen biomimetic liposomes: enhanced lung accumulation and synergistic chemoimmunotherapy
Fan Jia, Siyuan Peng, Wenhao Wang, Xin Pan,
2025, 15(6):3349-3350. DOI:10.1016/j.apsb.2025.05.032
Abstract
Unlocking the therapeutic potential of RNA splicing in lung fibrosis: Insights from the SRSF7-PKM axis
Bi-Sen Ding,
2025, 15(6):3351-3352. DOI:10.1016/j.apsb.2025.05.028
Abstract
Author correction to “The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery” [Acta Pharm Sin B 12 (2022) 1460-1472]
Jingyi Li, Yaqi Zhang, Miaorong Yu, Aohua Wang, Yu Qiu, Weiwei Fan, Lars Hovgaard, Mingshi Yang, Yiming Li, Rui Wang, Xiuying Li, Yong Gan,
2025, 15(6):3353-3353. DOI:10.1016/j.apsb.2025.04.015
Abstract
Publisher erratum to “Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway” [Acta Pharmaceutica Sinica B 14 (2024) 2992-3008]
Shicheng Fan, Yue Gao, Pengfei Zhao, Guomin Xie, Yanying Zhou, Xiao Yang, Xuan Li, Shuaishuai Zhang, Frank J. Gonzalez, Aijuan Qu, Min Huang, Huichang Bi,
2025, 15(6):3354-3354. DOI:10.1016/j.apsb.2025.04.016
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica