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Artificial intelligence and anti-cancer drugs' response
Xinrui Long, Kai Sun, Sicen Lai, Yuancheng Liu, Juan Su, Wangqing Chen, Ruhan Liu, Xiaoyu He, Shuang Zhao, Kai Huang,
2025, 15(7):3355-3371. DOI:10.1016/j.apsb.2025.05.009
Abstract
Trends in intestinal aging: From underlying mechanisms to therapeutic strategies
Yajun Wang, Xueni Zhang, Mengli Qing, Wen Dang, Xuemei Bai, Yingjie Wang, Di Zhou, Lingjuan Zhu, Degang Qing, Juan Zhang, Gang Chen, Ning Li,
2025, 15(7):3372-3403. DOI:10.1016/j.apsb.2025.05.011
Abstract
Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis
Yufei Hui, Xue Jiao, Li Yang, Dejin Lu, Yanbo Han, Wen Yang, Yanli Cao, Yuxi Miao, Shiqiang Gong, Minjie Wei,
2025, 15(7):3404-3418. DOI:10.1016/j.apsb.2025.04.022
Abstract
Immune organoid for cancer immunotherapy
Xiao-He Wang, Wu-Yin Wang, Zhi-Jun Sun,
2025, 15(7):3419-3435. DOI:10.1016/j.apsb.2025.04.031
Abstract
Unraveling the therapeutic landscape of approved non-peptide macrocycles
Zhonghua Li, Zhenqiang Zhang, Bin Yu,
2025, 15(7):3436-3459. DOI:10.1016/j.apsb.2025.04.021
Abstract
Extracellular vesicles as biomarkers and drug delivery systems for tumor
Xue Wang, Wenjing Chen, Wei Zeng, Kuanhan Feng, Yu Zheng, Ping Wang, Fucai Chen, Wen Zhang, Liuqing Di, Ruoning Wang,
2025, 15(7):3460-3486. DOI:10.1016/j.apsb.2025.04.033
Abstract
Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: Mechanism analysis and application prospects
Yuelin Huang, Chunting Wang, Yanhong Chen, Dengbin Wang, Defan Yao,
2025, 15(7):3487-3510. DOI:10.1016/j.apsb.2025.05.021
Abstract
Advances in research on biomaterials and stem cell/exosome-based strategies in the treatment of traumatic brain injury
Wenya Chi, Yingying He, Shuisheng Chen, Lingyi Guo, Yan Yuan, Rongjie Li, Ruiyao Liu, Dairan Zhou, Jianzhong Du, Tao Xu, Yuan Yu,
2025, 15(7):3511-3544. DOI:10.1016/j.apsb.2025.05.010
Abstract
Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells
Yuquan Tao, Yinuo Ma, Limei Gu, Ye Zhang, Qinchang Zhang, Lisha Zhou, Jie Pan, Meng Shen, Xuefei Zhuang, Linmei Pan, Weixing Shen, Chengtao Yu, Dan Dong, Dong Zhang, Tingsheng Ling, Yang Sun, Haibo Cheng,
2025, 15(7):3545-3560. DOI:10.1016/j.apsb.2025.05.013
Abstract
Enzyme-independent functions of HDAC3 in the adult heart
Sichong Qian, Chen Zhang, Wenbo Li, Shiyang Song, Guanqiao Lin, Zixiu Cheng, Wenjun Zhou, Huiqi Yin, Yueli Wang, Haiyang Li, Ying H. Shen, Zheng Sun,
2025, 15(7):3561-3574. DOI:10.1016/j.apsb.2025.05.002
Abstract
Antisense oligonucleotides targeting IRF4 alleviate psoriasis
Yanxia Yu, Yirui Wang, Weiwei Chen, Chang Zhang, Zhuo li, Jing Yu, Minhao Wang, Can Song, Sihao Yan, Jiayi Lu, Liangdan Sun,
2025, 15(7):3575-3590. DOI:10.1016/j.apsb.2025.05.004
Abstract
Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1
Xiaohui Zhang, Xinyu Tang, Ting Gao, Yuanfang Guo, Guangping Lu, Qingbo Liu, Jiahao Li, Jie Wang, Mingrui Liu, Dongmei Zhang, Yufeng Tang, Junlian Gu,
2025, 15(7):3591-3610. DOI:10.1016/j.apsb.2025.05.018
Abstract
RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis
Lijun Cai, Meimei Yin, Shuangzhou Peng, Fen Lin, Liangliang Lai, Xindao Zhang, Lei Xie, Chuanying Wang, Huiying Zhou, Yunfeng Zhan, Gulimiran Alitongbieke, Baohuan Lian, Zhibin Su, Tenghui Liu, Yuqi Zhou, Zongxi Li, Xiaohui Chen, Qi Zhao, Ting Deng, Lulu Chen, Jingwei Su, Luoyan Sheng, Ying Su, Ling-Juan Zhang, Fu-Quan Jiang, Xiao-Kun Zhang,
2025, 15(7):3611-3631. DOI:10.1016/j.apsb.2025.05.023
Abstract
Linagliptin synergizes with cPLA2 inhibition to enhance temozolomide efficacy by interrupting DPP4-mediated EGFR stabilization in glioma
Dongyuan Su, Biao Hong, Shixue Yang, Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kaikai Yi, Yanping Huang, Jiasheng Ju, Eryan Yang, Qixue Wang, Junhu Zhou, Yunfei Wang, Xing Liu, Chunsheng Kang,
2025, 15(7):3632-3645. DOI:10.1016/j.apsb.2025.05.012
Abstract
Discovery of Yersinia LcrV as a novel biased agonist of formyl peptide receptor 1 to bi-directionally modulate intracellular kinases in triple-negative breast cancer
Yunjun Ge, Huiwen Guan, Ting Li, Jie Wang, Liang Ying, Shuhui Guo, Jinjian Lu, Richard D. Ye, Guosheng Wu,
2025, 15(7):3646-3662. DOI:10.1016/j.apsb.2025.04.030
Abstract
Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection
Xiu Liu, Li Zhao, Deshen Liu, Lingna Zhao, Yonghua Tuo, Qinbao Peng, Fangze Huang, Zhengkun Song, Chuanjie Niu, Xiaoxia He, Yu Xu, Jun Wan, Peng Zhu, Zhengyang Jian, Jiawei Guo, Yingying Liu, Jun Lu, Sijia Liang, Shaoyi Zheng,
2025, 15(7):3663-3684. DOI:10.1016/j.apsb.2025.05.016
Abstract
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway
Xian-Jia Li, Ke-Xin Huang, Ke-Xin Wang, Ru Liu, Dong-Chao Wang, Yu-Ru Liang, Er-Jun Hao, Yang Wang, Hai-Ming Guo,
2025, 15(7):3685-3707. DOI:10.1016/j.apsb.2025.05.008
Abstract
CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury
Yong Chen, Xue Yuan, Wei Yan, Yurong Zou, Haoche Wei, Yuhan Wei, Minghai Tang, Yulian Chen, Ziyan Ma, Tao Yang, Kongjun Liu, Baojian Xiong, Xiuying Hu, Jianhong Yang, Lijuan Chen,
2025, 15(7):3708-3724. DOI:10.1016/j.apsb.2025.05.003
Abstract
Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture
Hui Chen, Hanqi Zhang, Chao Niu, Bianlin Wang, Biao Gao, Zhijun Liu, Guangmin Yao, Haji Akber Aisa,
2025, 15(7):3725-3737. DOI:10.1016/j.apsb.2025.04.032
Abstract
Autonomous drug delivery and scar microenvironment remodeling using micromotor-driven microneedles for hypertrophic scars therapy
Ting Wen, Yanping Fu, Xiangting Yi, Ying Sun, Wanchen Zhao, Chaonan Shi, Ziyao Chang, Beibei Yang, Shuling Li, Chao Lu, Tingting Peng, Chuanbin Wu, Xin Pan, Guilan Quan,
2025, 15(7):3738-3755. DOI:10.1016/j.apsb.2025.05.017
Abstract
Engineered platelet-derived exosomal spheres for enhanced tumor penetration and extended circulation in melanoma immunotherapy
Jian Zhao, Xinyan Lv, Qi Lu, Kaiyuan Wang, Lili Du, Xiaoyuan Fan, Fei Sun, Fengxiang Liu, Zhonggui He, Hao Ye, Jin Sun,
2025, 15(7):3756-3766. DOI:10.1016/j.apsb.2025.04.013
Abstract
A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers
Jialing Cheng, Zhiyang Chen, Demin Lin, Yanfang Yang, Yanjing Bai, Lingshuang Wang, Jie Li, Yuchen Wang, Hongliang Wang, Youbai Chen, Jun Ye, Yuling Liu,
2025, 15(7):3767-3787. DOI:10.1016/j.apsb.2025.04.020
Abstract
High intensity forced ultrasound-driven ferroptosis as a strategy for anti-tumor immune priming
Xuejing Li, Jiayi Wu, Ruizhe Xu, Xifeng Qin, Siyu Wang, Wuli Yang, Zhiqing Pang,
2025, 15(7):3788-3804. DOI:10.1016/j.apsb.2025.05.006
Abstract
Polymer-assisted PD-L1 degradation and targeted photodynamic therapy synergize to suppress immunodeficient tumors
Changyong Guo, Shipeng He, Huaxing Shen, Wei Cong, Jinqiu Li, Yajing Ji, Wenjing Huang, Fei Gao, Honggang Hu,
2025, 15(7):3805-3818. DOI:10.1016/j.apsb.2025.05.022
Abstract
Non-blocking anti-PD-L1 nanobody conjugated to TLR7 agonist mediates macrophage/NK cell-associated antitumor effects
Chao Hu, Chen Chen, Xiaolu Yu, Zhiying Li, Feng Tang, Qi Sun, Yiru Long, Likun Gong,
2025, 15(7):3819-3823. DOI:10.1016/j.apsb.2025.05.005
Abstract
Reshaping antivenom therapy: A triple-synergy strategy featuring broadly neutralizing antibodies and a small-molecule PLA2 inhibitor
Yangyihua Zhou, Ning Shi, Xiang Gao, Longlong Luo,
2025, 15(7):3824-3826. DOI:10.1016/j.apsb.2025.05.019
Abstract
Sympathetic nerve activity in obesity-associated insulin resistance
Shuchou Xia, Huili Wu, Jianping Ye,
2025, 15(7):3827-3828. DOI:10.1016/j.apsb.2025.01.018
Abstract
Traditional Chinese medicine in the early prevention of colorectal cancer from the perspective of tumor microenvironment
Huan Tang, Jigang Wang,
2025, 15(7):3829-3830. DOI:10.1016/j.apsb.2025.06.020
Abstract
A transformer-based strategy to develop RP20 as a potent RIPK2 inhibitor for acetaminophen-induced acute liver injury
Liang Ouyang,
2025, 15(7):3831-3832. DOI:10.1016/j.apsb.2025.06.003
Abstract

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