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Resistance mutations and the blood-brain barrier: Key challenges in targeted treatment of brain metastatic non-small cell lung cancer
Jamie Rijmers, Maria C. Lebre, Jos H. Beijnen, Alfred H. Schinkel,
2025, 15(8):3833-3851. DOI:10.1016/j.apsb.2025.06.002
Abstract
Next-generation antifungal drugs: Mechanisms, efficacy, and clinical prospects
Xueni Lu, Jianlin Zhou, Yi Ming, Yuan Wang, Ruirui He, Yangyang Li, Lingyun Feng, Bo Zeng, Yanyun Du, Chenhui Wang,
2025, 15(8):3852-3887. DOI:10.1016/j.apsb.2025.06.013
Abstract
Advances in immunoPET/SPECT imaging: The role of Fab and F(ab′)2 fragments in theranostics
Wenpeng Huang, Jingwei Zhou, Yanchen Liu, Yihan Yang, Rachel J. Saladin, Jessica C. Hsu, Weibo Cai, Lei Kang,
2025, 15(8):3888-3924. DOI:10.1016/j.apsb.2025.05.030
Abstract
Blades and barriers: Oral vaccines for conquering cancers and warding off infectious diseases
Kun Yang, Jinhua Liu, Yi Zhao, Haiting Xu, Menghang Zu, Baoyi Li, Xiaoxiao Shi, Rui L. Reis, Subhas C. Kundu, Bo Xiao,
2025, 15(8):3925-3950. DOI:10.1016/j.apsb.2025.05.038
Abstract
Engineering strategies of sequential drug delivery systems for combination tumor immunotherapy
Zhenyu Xu, Siyan Liu, Yanan Li, Yanping Wu, Jiasheng Tu, Qian Chen, Chunmeng Sun,
2025, 15(8):3951-3977. DOI:10.1016/j.apsb.2025.05.039
Abstract
FtsZ as a novel target for antibiotics development: Promises and challenges
Ming-Wei Wang, Kaini Hang, Wei Han, Xin Li, Qingtong Zhou, Dehua Yang,
2025, 15(8):3978-3996. DOI:10.1016/j.apsb.2025.06.008
Abstract
Augmentation of PRDX1-DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation
Wenzhen Dang, Xiaomin Wang, Huaying Li, Yixuan Xu, Xinyu Li, Siqi Huang, Hongru Tao, Xiao Li, Yulin Yang, Lijiang Xuan, Weilie Xiao, Dean Guo, Hao Zhang, Qiong Wu, Jie Zheng, Xiaoyan Shen, Kaixian Chen, Heng Xu, Yuanyuan Zhang, Cheng Luo,
2025, 15(8):3997-4013. DOI:10.1016/j.apsb.2025.06.006
Abstract
The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia-reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis
Tengfei Liu, Gan Huang, Xin Guo, Qiuran Ji, Lu Yu, Runzhe Zong, Yiquan Li, Xiaomeng Song, Qingyi Fu, Qidi Xue, Yi Zheng, Fanshuo Zeng, Ru Sun, Lin Chen, Chengjiang Gao, Huiqing Liu,
2025, 15(8):4014-4029. DOI:10.1016/j.apsb.2025.06.005
Abstract
Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction
Huan Yao, Qingman He, Shujun Wei, Li Xiang, Yuanyuan Luo, Cong Huang, Weiwei Liu, Chuan Zheng, Xueping Li, Yongxiang Gao,
2025, 15(8):4030-4046. DOI:10.1016/j.apsb.2025.06.014
Abstract
IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia
Jiaqi Li, Mingchao Wang, Kai Qu, Yuyao Sun, Zequn Yin, Na Dong, Xin Sun, Yitong Xu, Liang Chen, Shuang Zhang, Xunde Xian, Suowen Xu, Likun Ma, Yajun Duan, Haibo Zhu,
2025, 15(8):4047-4063. DOI:10.1016/j.apsb.2025.05.015
Abstract
Inhibition of WAC alleviates the chondrocyte proinflammatory secretory phenotype and cartilage degradation via H2BK120ub1 and H3K27me3 coregulation
Peitao Xu, Guiwen Ye, Xiaojun Xu, Zhidong Liu, Wenhui Yu, Guan Zheng, Zepeng Su, Jiajie Lin, Yunshu Che, Yipeng Zeng, Zhikun Li, Pei Feng, Qian Cao, Zhongyu Xie, Yanfeng Wu, Huiyong Shen, Jinteng Li,
2025, 15(8):4064-4077. DOI:10.1016/j.apsb.2025.06.015
Abstract
Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure
Yumeng Miao, Tzuchun Lin, Bianlin Wang, Junyu Xu, Chongxian Li, Zuopeng Li, Xinwen Zhang, Chendong Zhou, Tuerganaili Aji, Minjia Tan, Haji Akber Aisa, Jingya Li,
2025, 15(8):4078-4095. DOI:10.1016/j.apsb.2025.06.019
Abstract
Downregulation of ubiquitous microRNA-320 in hepatocytes triggers RFX1-mediated FGF1 suppression to accelerate MASH progression
Liu Yang, Wenjun Li, Yingfen Chen, Ru Ya, Shengying Qian, Li Liu, Yawen Hao, Qiuhong Zai, Peng Xiao, Seonghwan Hwang, Yong He,
2025, 15(8):4096-4114. DOI:10.1016/j.apsb.2025.06.007
Abstract
Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors
Xiao-Mei Chen, Qing-Qing Hao, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Fen-Er Chen,
2025, 15(8):4115-4136. DOI:10.1016/j.apsb.2025.06.016
Abstract
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis
Jianyu Yan, Tianyu Wang, Ruizhi Yu, Lijuan Xu, Hongming Shao, Tengfei Li, Zhe Wang, Xudong Cha, Zhenyuan Miao, Chengguo Xing, Ke Xu, Huanhai Liu, Chunlin Zhuang,
2025, 15(8):4137-4155. DOI:10.1016/j.apsb.2025.05.025
Abstract
A novel C-3-substituted oleanolic acid benzyl amide derivative exhibits therapeutic potential against influenza A by targeting PA-PB1 interactions and modulating host macrophage inflammation
Kunyu Lu, Jianfu He, Chongjun Hong, Haowei Li, Jiaai Ruan, Jinshen Wang, Haoxing Yuan, Binhao Rong, Chan Yang, Gaopeng Song, Shuwen Liu,
2025, 15(8):4156-4173. DOI:10.1016/j.apsb.2025.05.031
Abstract
High-efficient discovering the potent anti-Notum agents from herbal medicines for combating glucocorticoid-induced osteoporosis
Yuqing Song, Feng Zhang, Jia Guo, Yufan Fan, Hairong Zeng, Mengru Sun, Jun Qian, Shenglan Qi, Zihan Chen, Xudong Jin, Yunqing Song, Tian Tian, Zhi Qian, Yao Sun, Zhenhao Tian, Baoqing Yu, Guangbo Ge,
2025, 15(8):4174-4192. DOI:10.1016/j.apsb.2025.06.004
Abstract
AI-integrated IQPD framework of quality prediction and diagnostics in small-sample multi-unit pharmaceutical manufacturing: Advancing from experience-driven to data-driven manufacturing
Kaiyi Wang, Xinhai Chen, Nan Li, Huimin Feng, Xiaoyi Liu, Yifei Wang, Yanfei Wu, Yufeng Guo, Shuoshuo Xu, Lu Yao, Zhaohua Zhang, Jun Jia, Zhishu Tang, Zhisheng Wu,
2025, 15(8):4193-4209. DOI:10.1016/j.apsb.2025.06.001
Abstract
Dual-ferroptosis induction-based microneedle patches for enhanced chemodynamic/photothermal combination therapy against triple-negative breast cancer
Yujie Wang, Zhaoyou Chu, Peisan Wang, Tao Li, Yu Jin, Silong Wu, Xiaowei Song, Weinan Zhang, Miaomiao Yang, Zhengbao Zha, Haisheng Qian, Yan Ma,
2025, 15(8):4210-4224. DOI:10.1016/j.apsb.2025.05.034
Abstract
Improved prebiotic-based “shield” equipped probiotics for enhanced colon cancer therapy by polarizing M1 macrophages and regulating intestinal microbiota
Yang Wang, Xiaomin Su, Yao Liu, Lina Hu, Lin Kang, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Shun Shen,
2025, 15(8):4225-4247. DOI:10.1016/j.apsb.2025.05.040
Abstract
Artificial mesenchymal stem cell extracellular vesicles enhanced ischemic stroke treatment through targeted remodeling brain microvascular endothelial cells
Shengnan Li, Wei Lv, Jiangna Xu, Jiaqing Yin, Yuqin Chen, Linfeng Liu, Xiang Cao, Wenjing Li, Zhen Li, Hua Chen, Hongliang Xin,
2025, 15(8):4248-4264. DOI:10.1016/j.apsb.2025.06.009
Abstract
Unveiling the renoprotective mechanisms of self-assembled herbal nanoparticles from Scutellaria barbata and Scleromitrion diffusum in acute kidney injury: A nano-TCM approach
Lunyue Xia, Qunfang Yang, Kangzhe Fu, Yutong Yang, Kaiyue Ding, Yuexue Huo, Lanfang Zhang, Yunong Li, Borong Zhu, Peiyu Li, Yijie Huo, Liang Sun, Ya Liu, Haigang Zhang, Tao Liu, Wenjun Shan, Lin Zhang,
2025, 15(8):4265-4284. DOI:10.1016/j.apsb.2025.05.024
Abstract
Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging
Pu Jiang, Ruihu Song, Yue Hu, Xin He, Zewei Zhang, Xuemei Wei, Zhiming Wang, De-an Guo, Hao Chen,
2025, 15(8):4285-4299. DOI:10.1016/j.apsb.2025.06.023
Abstract
A simple widely applicable hairy root transformation method for gene function studies in medicinal plants
Xue Cao, Zhenfen Qin, Panhui Fan, Sifan Wang, Xiangxiao Meng, Huihua Wan, Wei Yang, Shilin Chen, Hui Yao, Weiqiang Chen, Wei Sun,
2025, 15(8):4300-4305. DOI:10.1016/j.apsb.2025.03.038
Abstract
APOE2 reduces risk of Alzheimer's disease by protection of lysosomes from lipid overloading
Jing Feng, Xiwen Ma, Jianping Ye,
2025, 15(8):4306-4308. DOI:10.1016/j.apsb.2025.03.001
Abstract
Targeting the coronavirus membrane protein: A promising novel therapeutic strategy
Dazhou Shi, Chunhua Ma, Shujing Xu, Peng Zhan,
2025, 15(8):4309-4312. DOI:10.1016/j.apsb.2025.05.029
Abstract
From S-nitrosation targets to drugs: A potential new paradigm in disease treatment
Hui Ye, Jianbing Wu, Chen Zhang, Duorui Ji, Yihua Zhang, Zhangjian Huang,
2025, 15(8):4313-4315. DOI:10.1016/j.apsb.2025.05.035
Abstract
Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy
Fan Tong, Hanmei Li, Huile Gao, Yuan Li,
2025, 15(8):4316-4318. DOI:10.1016/j.apsb.2025.05.033
Abstract
Nanocoated bacterial carriers enhance oral bacteriophage delivery efficiency
Yingui Cao, Aodi Jiang, Qiang Gao, Bo Xiao,
2025, 15(8):4319-4321. DOI:10.1016/j.apsb.2025.05.037
Abstract
A5—A dual-target antiviral compound that rewrites the rules of influenza therapy
Shibo Jiang,
2025, 15(8):4322-4323. DOI:10.1016/j.apsb.2025.07.033
Abstract
HomoPROTACKeap1: A new strategy of chemical knockdown of Keap1 for allergic rhinitis
Xiaofeng Qi,
2025, 15(8):4324-4325. DOI:10.1016/j.apsb.2025.07.032
Abstract

Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica