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Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions
Fang Ren, Jing Wei, Qingxin Chen, Mengling Hu, Lu Yu, Jianing Mi, Xiaogang Zhou, Dalian Qin, Jianming Wu, Anguo Wu,
2025, 15(9):4327-4385. DOI:10.1016/j.apsb.2025.07.030
Abstract
Artificial intelligence in drug development for delirium and Alzheimer's disease
Ruixue Ai, Xianglu Xiao, Shenglong Deng, Nan Yang, Xiaodan Xing, Leiv Otto Watne, Geir Selbæk, Yehani Wedatilake, Chenglong Xie, David C. Rubinsztein, Jennifer E. Palmer, Bjørn Erik Neerland, Hongming Chen, Zhangming Niu, Guang Yang, Evandro Fei Fang,
2025, 15(9):4386-4410. DOI:10.1016/j.apsb.2025.04.026
Abstract
A computational medicine framework integrating multi-omics, systems biology, and artificial neural networks for Alzheimer's disease therapeutic discovery
Yisheng Yang, Yizhu Diao, Lulu Jiang, Fanlu Li, Liye Chen, Ming Ni, Zheng Wang, Hai Fang,
2025, 15(9):4411-4426. DOI:10.1016/j.apsb.2025.07.018
Abstract
AI-powered model for accurate prediction of MCI-to-AD progression
Ahmed Abdelhameed, Jingna Feng, Xinyue Hu, Fang Li, Sori Lundin, Paul E. Schulz, Cui Tao,
2025, 15(9):4427-4437. DOI:10.1016/j.apsb.2025.01.027
Abstract
Biased signaling via serotonin 5-HT2A receptor: From structural aspects to in vitro and in vivo pharmacology
Michał K. Jastrzębski, Piotr Wójcik, Angelika Grudzińska, Giorgia Andreozzi, Tommaso Vetrò, Ayesha Asim, Akanksha Mudgal, Jakub Czapiński, Tomasz M. Wróbel, Damian Bartuzi, Katarzyna M. Targowska-Duda, Agnieszka A. Kaczor,
2025, 15(9):4438-4455. DOI:10.1016/j.apsb.2025.07.002
Abstract
Understanding the complexity of tumor-associated macrophages: Druggable and therapeutic insights
An-Qi Li, Fang Huang, Sulaiya Talaiti, Xiao Yang, Huichang Bi, Jian-Hong Fang,
2025, 15(9):4456-4475. DOI:10.1016/j.apsb.2025.07.021
Abstract
Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy
Haojun Wang, Yang Yu, Runze Li, Huiru Zhang, Zhe-sheng Chen, Changgang Sun, Jing Zhuang,
2025, 15(9):4476-4496. DOI:10.1016/j.apsb.2025.07.022
Abstract
The role of SARS-CoV-2 main protease in innate immune regulation: From molecular mechanisms to therapeutic implications
Yumeng Gao, Jun Zhang,
2025, 15(9):4497-4510. DOI:10.1016/j.apsb.2025.07.001
Abstract
Fibroblast activation protein targeting radiopharmaceuticals: From drug design to clinical translation
Yuxuan Wu, Xingkai Wang, Xiaona Sun, Xin Gao, Siqi Zhang, Jieting Shen, Hao Tian, Xueyao Chen, Hongyi Huang, Shuo Jiang, Boyang Zhang, Yingzi Zhang, Minzi Lu, Hailong Zhang, Zhicheng Sun, Ruping Liu, Hong Zhang, Ming-Rong Zhang, Kuan Hu, Rui Wang,
2025, 15(9):4511-4542. DOI:10.1016/j.apsb.2025.07.009
Abstract
Ischemic stroke and intervention strategies based on the timeline of stroke progression: Review and prospects
Anning Xu, Honghua Zhang, Yihua Zhang, Jianbing Wu, Zhangjian Huang,
2025, 15(9):4543-4581. DOI:10.1016/j.apsb.2025.07.026
Abstract
Nanomedicine strategies for cuproptosis: Metabolic reprogramming and tumor immunotherapy
Ruixuan Zhang, Yunfei Li, Hui Fu, Chengcheng Zhao, Xiuyan Li, Yuming Wang, Yujiao Sun, Yingpeng Li,
2025, 15(9):4582-4613. DOI:10.1016/j.apsb.2025.07.007
Abstract
Metallic nanomedicine in cancer immunotherapy
Shixuan Li, Xiaohu Wang, Huiyun Han, Shuting Xiang, Mingxi Li, Guangyu Long, Yanming Xia, Qiang Zhang, Suxin Li,
2025, 15(9):4614-4643. DOI:10.1016/j.apsb.2025.07.017
Abstract
Natural vaccine adjuvants from traditional Chinese medicines: Mechanisms to applications
Xiaoyuan Fan, Fengxiang Liu, Fei Sun, Yiyang Wang, Wenwen Shen, Shujun Wang, Jin Sun, Kaiyuan Wang,
2025, 15(9):4644-4672. DOI:10.1016/j.apsb.2025.06.021
Abstract
PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradation
Xiangyu Li, Xiaoyu Shen, Xinfei Mao, Yuqing Wang, Yuhang Dong, Shuai Sun, Mengmeng Zhang, Jie Wei, Jianan Wang, Chao Li, Minglu Ji, Xiaowei Hu, Xinyu Chen, Juan Jin, Jiagen Wen, Yujie Liu, Mingfei Wu, Jutao Yu, Xiaoming Meng,
2025, 15(9):4673-4691. DOI:10.1016/j.apsb.2025.07.019
Abstract
Astrocytic dopamine D1 receptor modulates glutamatergic transmission and synaptic plasticity in the prefrontal cortex through d-serine
Yanan Yin, Jian Hu, Haipeng Wu, Xinyu Yang, Jingwen Qi, Lang Huang, Zhengyi Luo, Shiyang Jin, Nengyuan Hu, Zhoucai Luo, Tong Luo, Hao Chen, Xiaowen Li, Chunhua Yuan, Shuji Li, Jianming Yang, Yihua Chen, Tianming Gao,
2025, 15(9):4692-4710. DOI:10.1016/j.apsb.2025.07.034
Abstract
Evidence that metformin promotes fibrosis resolution via activating alveolar epithelial stem cells and FGFR2b signaling
Yuqing Lv, Yanxia Zhang, Xueli Guo, Baiqi He, Haibo Xu, Ming Xu, Lihui Zou, Handeng Lyu, Jin Wu, Pingping Zeng, Saverio Bellusci, Xuru Jin, Chengshui Chen, Young-Chang Cho, Xiaokun Li, Jin-San Zhang,
2025, 15(9):4711-4729. DOI:10.1016/j.apsb.2025.07.023
Abstract
Astrocyte FGF7/FGFR2 autocrine signaling mediates neuroinflammation and promotes MPTP-induced degeneration of dopaminergic neurons
Xin Sun, Yueping Wang, Yajie Zhang, Ruixue Han, Min Wang, Jing Zhang, Ting Sun, Yang Liu, Gang Hu, Lei Cao, Ming Lu,
2025, 15(9):4730-4750. DOI:10.1016/j.apsb.2025.07.012
Abstract
USP20 as a super-enhancer-regulated gene drives T-ALL progression via HIF1A deubiquitination
Ling Xu, Zimu Zhang, Juanjuan Yu, Tongting Ji, Jia Cheng, Xiaodong Fei, Xinran Chu, Yanfang Tao, Yan Xu, Pengju Yang, Wenyuan Liu, Gen Li, Yongping Zhang, Yan Li, Fenli Zhang, Ying Yang, Bi Zhou, Yumeng Wu, Zhongling Wei, Yanling Chen, Jianwei Wang, Di Wu, Xiaolu Li, Yang Yang, Guanghui Qian, Hongli Yin, Shuiyan Wu, Shuqi Zhang, Dan Liu, Jun-jie Fan, Lei Shi, Xiaodong Wang, Shaoyan Hu, Jun Lu, Jian Pan,
2025, 15(9):4751-4771. DOI:10.1016/j.apsb.2025.07.003
Abstract
Deubiquitinase OTUD6A alleviates acetaminophen-induced liver injury by targeting EZH2 to reduce cell death in hepatocytes
Yanni Zhao, Tianyang Jin, Tingxin Xu, Yi Fang, Qingsong Zheng, Wu Luo, Weiwei Zhu, Yue Chen, Jiong Wang, Yi Chen, Wei Zuo, Lijiang Huang, Guang Liang, Yi Wang,
2025, 15(9):4772-4788. DOI:10.1016/j.apsb.2025.06.027
Abstract
Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis
Xuewen Yang, Yanwei Zhang, Xiaoping Leng, Yanying Wang, Manyu Gong, Dongping Liu, Haodong Li, Zhiyuan Du, Zhuo Wang, Lina Xuan, Ting Zhang, Han Sun, Xiyang Zhang, Jie Liu, Tong Liu, Tiantian Gong, Zhengyang Li, Shengqi Liang, Lihua Sun, Lei Jiao, Baofeng Yang, Ying Zhang,
2025, 15(9):4789-4806. DOI:10.1016/j.apsb.2025.07.011
Abstract
Pleiotropic prodrugs for both symptomatic and disease-modifying treatment of Alzheimer's disease
Anže Meden, Neža Žnidaršič, Damijan Knez, Yuanyuan Wang, Ziwei Xu, Huajing Yang, Weiting Zhang, Anja Pišlar, Andrej Perdih, Simona Kranjc Brezar, Neža Grgurevič, Stane Pajk, Haopeng Sun, Stanislav Gobec,
2025, 15(9):4807-4828. DOI:10.1016/j.apsb.2025.07.005
Abstract
Yeast-two-hybrid based high-throughput screening to discover SARS-CoV-2 fusion inhibitors by targeting the HR1/HR2 interaction
Jing Zhang, Dongsheng Li, Wenwen Zhou, Chao Liu, Peirong Wang, Baoqing You, Bingjie Su, Keyu Guo, Wenjing Shi, Tin Mong Timothy Yung, Richard Yi Tsun Kao, Peng Gao, Yan Li, Shuyi Si,
2025, 15(9):4829-4843. DOI:10.1016/j.apsb.2025.06.029
Abstract
Discovery of powerful multifaceted antioxidant for combating oxidative stress associated with neurodegenerative disorders
Juhee khan, Prabir kumar Gharai, Shubham Garg, Sanju Gupta, Mohammad Umar Arshi, Rathnam Mallesh, Surajit Ghosh,
2025, 15(9):4844-4871. DOI:10.1016/j.apsb.2025.04.024
Abstract
The toxic components, toxicological mechanism and effective antidote for Gelsemium elegans poisoning
Niping Li, Yaorong Yang, Shengyuan Zhang, Bin Jiang, Wei Zhang, Haibo Wang, Lixin Chen, Liwei Wang, Yiyi Li, Lei Shi, Wencai Ye, Lei Wang,
2025, 15(9):4872-4885. DOI:10.1016/j.apsb.2025.07.016
Abstract
Activatable PROTAC nanoassembly for photodynamic PTP1B proteolysis enhances glioblastoma immunotherapy
Yeongji Jang, Jiwoong Choi, Byeongmin Park, Jung Yeon Park, Jae-Hyeon Lee, Jagyeong Goo, Dongwon Shin, Sun Hwa Kim, Yongju Kim, Hyun Kyu Song, Jooho Park, Kwangmeyung Kim, Yoosoo Yang, Man Kyu Shim,
2025, 15(9):4886-4899. DOI:10.1016/j.apsb.2025.06.028
Abstract
Intercellular communication interference through energy metabolism-related exosome secretion inhibition for liver fibrosis treatment
Mengyao Zhang, Huaqing Jing, Xinyi Liu, Valentin A. Milichko, Yunsheng Dou, Yingzi Ren, Zitong Qiu, Wen Li, Weili Liu, Xinxing Wang, Nan Li,
2025, 15(9):4900-4916. DOI:10.1016/j.apsb.2025.07.008
Abstract
A novel dual-targeting strategy of nanobody-driven protein corona modulation for glioma therapy
Yupei Zhang, Shugang Qin, Tingting Song, Zhiying Huang, Zekai Lv, Yang Zhao, Xiangyu Jiao, Min Sun, Yinghan Zhang, Guang Xie, Yuting Chen, Xuli Ruan, Ruyue Liu, Haixing Shi, Chunli Yang, Siyu Zhao, Zhongshan He, Hai Huang, Xiangrong Song,
2025, 15(9):4917-4931. DOI:10.1016/j.apsb.2025.07.014
Abstract
KRAS mutant colon cancer-targeted induction of ferroptosis via photocatalytic activation of BiVO4-embedded silica nano with cascadic downregulation of GPX4/xCT axis
Yixin Jiang, Ratchapol Jenjob, Dahee Ryu, Zheyu Shen, Su-Geun Yang,
2025, 15(9):4932-4944. DOI:10.1016/j.apsb.2025.06.024
Abstract
Photodynamic enhancement of PROTAC prodrug activation in hypoxic tumors
Zhongliang Fu, Chunrong Yang, Yuchen Yang, Meichen Pan, Hongwei Hou, Jinghong Li,
2025, 15(9):4945-4960. DOI:10.1016/j.apsb.2025.07.020
Abstract
Mechanism of weight regain - The role of epigenetic modification in adipocytes
Yue Zhao, Xiwen Ma, Jianping Ye,
2025, 15(9):4961-4963. DOI:10.1016/j.apsb.2025.02.002
Abstract
Chemical and genetic molecular glues to degrade CoREST corepressors
Ying-Qi Song, Qingjun Li, Chunquan Sheng,
2025, 15(9):4964-4966. DOI:10.1016/j.apsb.2025.07.006
Abstract
From synaptic gatekeepers to affective-cognitive modulators: The astrocyte D1 receptor-d-serine axis in the prefrontal cortex
Li-Pao Fang, Frank Kirchhoff,
2025, 15(9):4967-4969. DOI:10.1016/j.apsb.2025.08.018
Abstract
Targeting PARylated RACK1/HIF-1α axis: A novel mechanism in acute kidney injury and therapeutic promise
Jiafa Ren, Steven D. Crowley,
2025, 15(9):4970-4971. DOI:10.1016/j.apsb.2025.08.004
Abstract
Author correction to “Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways” [Acta Pharm Sin B 15 (2025) 2024-2038]
Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang,
2025, 15(9):4972-4972. DOI:10.1016/j.apsb.2025.06.017
Abstract

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