Nitin Bharat Charbe, Nikhil D. Amnerkar, B. Ramesh, Murtaza M. Tambuwala, Hamid A. Bakshi, Alaa A. A. Aljabali, Saurabh C. Khadse, Rajendran Satheeshkumar, Saurabh Satija, Meenu Metha, Dinesh Kumar Chellappan, Garima Shrivastava, Gaurav Gupta, Poonam Negi, Kamal Dua, Flavia C. Zacconi. Small interfering RNA for cancer treatment: overcoming hurdles in deliveryJ. Acta Pharmaceutica Sinica B, 2020, 10(11): 2075-2109. DOI: 10.1016/j.apsb.2020.10.005
Citation: Nitin Bharat Charbe, Nikhil D. Amnerkar, B. Ramesh, Murtaza M. Tambuwala, Hamid A. Bakshi, Alaa A. A. Aljabali, Saurabh C. Khadse, Rajendran Satheeshkumar, Saurabh Satija, Meenu Metha, Dinesh Kumar Chellappan, Garima Shrivastava, Gaurav Gupta, Poonam Negi, Kamal Dua, Flavia C. Zacconi. Small interfering RNA for cancer treatment: overcoming hurdles in deliveryJ. Acta Pharmaceutica Sinica B, 2020, 10(11): 2075-2109. DOI: 10.1016/j.apsb.2020.10.005
shu
    Abstract
  • In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool to deliver DNA-based products to cancer cells. This review aims to highlight the latest development in the lipids and polymeric nanocarrier for siRNA delivery to the cancer cells. It also provides the necessary information about siRNA development and its mechanism of action. Overall, this review gives us a clear picture of lipid and polymer-based drug delivery systems, which in the future could form the base to translate the basic siRNA biology into siRNA-based cancer therapies.
    • FullText(HTML)
  • loading
    • References (171)
    • Relative Articles
  • Supplements (1)

Catalog

    Copyright © 2014 Editorial Office of Acta Pharmaceutica Sinica

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return